SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 TYR A 545
GLY A 549
ARG A 530
PHE A 374
 None
 0.90A 1gsfA-5dkuA:
undetectable		 1gsfA-5dkuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 TYR A 545
GLY A 549
ARG A 530
PHE A 374
 None
 0.90A 1gsfB-5dkuA:
3.4		 1gsfB-5dkuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 TYR A 545
GLY A 549
ARG A 530
PHE A 374
 None
 0.91A 1gsfC-5dkuA:
3.4		 1gsfC-5dkuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 TYR A 545
GLY A 549
ARG A 530
PHE A 374
 None
 0.91A 1gsfD-5dkuA:
undetectable		 1gsfD-5dkuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A  83
ILE A 181
ILE A 154
ILE A 157
ILE A 246
 None
 0.81A 1oipA-5dkuA:
undetectable		 1oipA-5dkuA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 5 LEU A 438
ALA A 462
LEU A 441
SER A 444
 None
 1.09A 1tt6B-5dkuA:
undetectable		 1tt6B-5dkuA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 5 ILE A 399
ASN A 263
ILE A 397
ASP A 260
 None
 1.06A 2h4jA-5dkuA:
undetectable		 2h4jA-5dkuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 ILE A 465
ALA A 482
ILE A 461
PHE A 498
 None
 0.82A 2w9sE-5dkuA:
undetectable		 2w9sE-5dkuA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		5 / 10 ALA A 212
LEU A  97
LEU A 204
ILE A  59
PHE A  57
 None
 1.11A 3fl9E-5dkuA:
undetectable		 3fl9E-5dkuA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		5 / 12 ALA A 212
LEU A  97
LEU A 204
ILE A  59
PHE A  57
 None
 1.11A 3fl9G-5dkuA:
undetectable		 3fl9G-5dkuA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 6 LEU A 609
SER A 606
PHE A 608
ILE A 554
 None
 0.94A 3ko0B-5dkuA:
undetectable		 3ko0B-5dkuA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		5 / 9 PHE A 498
LEU A 488
ILE A 461
ALA A 462
ALA A 482
 None
 0.98A 3mdvA-5dkuA:
undetectable		 3mdvA-5dkuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		5 / 12 PHE A 498
LEU A 488
ILE A 461
ALA A 462
ALA A 482
 None
 0.97A 3mdvB-5dkuA:
undetectable		 3mdvB-5dkuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 7 SER A 626
TRP A 624
PHE A 406
GLU A 396
 None
 1.36A 3n5tA-5dkuA:
undetectable
3n5tB-5dkuA:
undetectable		 3n5tA-5dkuA:
19.52
3n5tB-5dkuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 SER A 202
ASN A 114
PHE A 113
ASN A 201
 None
 1.13A 3n62A-5dkuA:
undetectable		 3n62A-5dkuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 SER A 202
ASN A 114
PHE A 113
ASN A 201
 None
 1.18A 3n66B-5dkuA:
undetectable		 3n66B-5dkuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 SER A 617
GLN A 413
ILE A 418
VAL A 547
 None
 0.92A 4dx7B-5dkuA:
3.5		 4dx7B-5dkuA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 5 ILE A 157
LEU A 247
LYS A 244
ASN A 156
 None
 1.09A 4g19A-5dkuA:
undetectable		 4g19A-5dkuA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 4 ILE A 157
LEU A 247
LYS A 244
ASN A 156
 None
 1.12A 4g19D-5dkuA:
undetectable		 4g19D-5dkuA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 7 SER A 202
ASN A 114
PHE A 113
ASN A 201
 None
 1.13A 4kcnB-5dkuA:
undetectable		 4kcnB-5dkuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		5 / 12 GLY A 549
GLY A 376
PHE A 374
THR A 526
LEU A 527
 None
 1.29A 4n48A-5dkuA:
undetectable		 4n48A-5dkuA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 SER A 164
ALA A 163
LEU A 222
LEU A 219
 None
 0.99A 5dzkF-5dkuA:
undetectable
5dzkT-5dkuA:
undetectable		 5dzkF-5dkuA:
14.93
5dzkT-5dkuA:
1.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 6 PHE A 608
SER A 617
VAL A 616
ASP A 579
 None
 1.29A 5hesA-5dkuA:
undetectable		 5hesA-5dkuA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 7 THR A 526
LEU A 555
VAL A 560
GLU A 602
 None
 1.09A 5tudA-5dkuA:
3.9		 5tudA-5dkuA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 SER A 626
TRP A 624
PHE A 406
GLU A 396
 None
 1.31A 5uo7A-5dkuA:
undetectable
5uo7B-5dkuA:
undetectable		 5uo7A-5dkuA:
19.44
5uo7B-5dkuA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 SER A 202
ASN A 114
PHE A 113
ASN A 201
 None
 1.15A 5vunA-5dkuA:
undetectable		 5vunA-5dkuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 SER A 202
ASN A 114
PHE A 113
ASN A 201
 None
 1.10A 5vunB-5dkuA:
undetectable		 5vunB-5dkuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 SER A 202
ASN A 114
PHE A 113
ASN A 201
 None
 1.11A 5vuoB-5dkuA:
undetectable		 5vuoB-5dkuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5dku PREX DNA POLYMERASE
(Plasmodium
falciparum) 		4 / 8 SER A 202
ASN A 114
PHE A 113
ASN A 201
 None
 1.17A 6auuB-5dkuA:
undetectable		 6auuB-5dkuA:
20.12