SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dkx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4001_1
(SERUM ALBUMIN)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 ARG A 188
LYS A 172
ASP A 189
GLY A 190
 None
 1.29A 1e7bB-5dkxA:
undetectable		 1e7bB-5dkxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 TYR A 167
GLY A 168
GLY A  77
SER A 105
 None
 0.94A 1eswA-5dkxA:
12.0		 1eswA-5dkxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 MET A 557
LEU A 315
ALA A 302
VAL A 568
 TRS  A1001 (-3.5A)
None
None
None
 0.76A 1sn5C-5dkxA:
undetectable		 1sn5C-5dkxA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 HIS A 691
PHE A 666
ILE A 480
TRP A 415
 TRS  A1001 (-4.0A)
TRS  A1001 (-4.5A)
None
None
 1.22A 1tdnA-5dkxA:
undetectable		 1tdnA-5dkxA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A 677
SER A 721
TYR A 720
 None
 0.72A 1x70A-5dkxA:
3.7		 1x70A-5dkxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 481
ARG A 689
LEU A 601
PHE A 453
PHE A 544
 None
 1.25A 1y0xX-5dkxA:
undetectable		 1y0xX-5dkxA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 SER A 258
GLU A 243
ASP A  40
 None
 0.72A 2avdB-5dkxA:
undetectable		 2avdB-5dkxA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 186
ARG A 109
THR A  99
LEU A  98
 None
 0.88A 2eijN-5dkxA:
undetectable
2eijW-5dkxA:
undetectable		 2eijN-5dkxA:
18.91
2eijW-5dkxA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PHE A 186
ARG A 109
THR A  99
LEU A  98
 None
 0.79A 2eikA-5dkxA:
undetectable
2eikJ-5dkxA:
undetectable		 2eikA-5dkxA:
18.91
2eikJ-5dkxA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 186
ARG A 109
THR A  99
LEU A  98
 None
 0.85A 2eikN-5dkxA:
undetectable
2eikW-5dkxA:
undetectable		 2eikN-5dkxA:
18.91
2eikW-5dkxA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 186
ARG A 109
THR A  99
LEU A  98
 None
 0.83A 2eilN-5dkxA:
undetectable
2eilW-5dkxA:
undetectable		 2eilN-5dkxA:
18.91
2eilW-5dkxA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ASP A 303
ASP A 443
ILE A 444
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.35A 2qmjA-5dkxA:
39.9		 2qmjA-5dkxA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ASP A 303
ASP A 443
ILE A 444
ILE A 480
TRP A 517
ASP A 556
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.36A 2qmjA-5dkxA:
39.9		 2qmjA-5dkxA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ASP A 443
ILE A 444
ILE A 480
TRP A 517
ASP A 482
 TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
None
 1.32A 2qmjA-5dkxA:
39.9		 2qmjA-5dkxA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 TRP A 554
MET A 557
TRP A 630
THR A 635
 TRS  A1001 (-4.9A)
TRS  A1001 (-3.5A)
None
None
 0.32A 2qmjA-5dkxA:
40.0		 2qmjA-5dkxA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 9 ALA A 733
ALA A 394
GLY A 398
GLY A 655
ILE A 390
 None
 1.15A 2v7bA-5dkxA:
undetectable		 2v7bA-5dkxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 9 ALA A 733
ALA A 394
GLY A 398
GLY A 655
ILE A 390
 None
 1.18A 2v7bB-5dkxA:
undetectable		 2v7bB-5dkxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		6 / 12 ASP A 303
ASP A 443
ASP A 556
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.56A 2x2iA-5dkxA:
31.7		 2x2iA-5dkxA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 TRP A 554
MET A 557
ARG A 617
TRP A 630
 TRS  A1001 (-4.9A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
None
 0.56A 2x2iA-5dkxA:
31.7		 2x2iA-5dkxA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ASP A 303
ASP A 443
ASP A 556
MET A 557
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.60A 2x2iB-5dkxA:
35.9		 2x2iB-5dkxA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ASP A 303
ASP A 443
ASP A 556
MET A 557
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.54A 2x2iC-5dkxA:
31.9		 2x2iC-5dkxA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ASP A 303
ASP A 443
ASP A 556
MET A 557
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.53A 2x2iD-5dkxA:
37.4		 2x2iD-5dkxA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 186
ARG A 109
THR A  99
LEU A  98
 None
 0.78A 3ablN-5dkxA:
undetectable
3ablW-5dkxA:
undetectable		 3ablN-5dkxA:
18.91
3ablW-5dkxA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 186
ARG A 109
THR A  99
LEU A  98
 None
 0.89A 3ag3N-5dkxA:
undetectable
3ag3W-5dkxA:
undetectable		 3ag3N-5dkxA:
18.91
3ag3W-5dkxA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 781
ILE A 783
PHE A 761
LEU A 649
GLN A 760
 None
 1.24A 3apwB-5dkxA:
undetectable		 3apwB-5dkxA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 186
ARG A 109
THR A  99
LEU A  98
 None
 0.89A 3asnN-5dkxA:
undetectable
3asnW-5dkxA:
undetectable		 3asnN-5dkxA:
18.91
3asnW-5dkxA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 TRP A 141
VAL A 614
ARG A 689
 None
 0.87A 3b0wA-5dkxA:
undetectable		 3b0wA-5dkxA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 GLU A 137
HIS A 576
HIS A 577
 None
 0.90A 3co4A-5dkxA:
4.9		 3co4A-5dkxA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.14A 3eeyA-5dkxA:
undetectable		 3eeyA-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.12A 3eeyB-5dkxA:
undetectable		 3eeyB-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.13A 3eeyC-5dkxA:
undetectable		 3eeyC-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.14A 3eeyD-5dkxA:
undetectable		 3eeyD-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.12A 3eeyE-5dkxA:
undetectable		 3eeyE-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.12A 3eeyH-5dkxA:
undetectable		 3eeyH-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.11A 3eeyI-5dkxA:
undetectable		 3eeyI-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.13A 3eeyJ-5dkxA:
undetectable		 3eeyJ-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ASP A 189
PHE A 173
SER A 330
 None
 0.93A 3i5uB-5dkxA:
undetectable		 3i5uB-5dkxA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 GLU A 395
GLY A 398
THR A 399
 None
 0.54A 3iazA-5dkxA:
undetectable		 3iazA-5dkxA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 GLY A 767
ILE A 919
PHE A 972
GLY A 859
PHE A 881
 None
 1.42A 3ko0R-5dkxA:
undetectable
3ko0T-5dkxA:
undetectable		 3ko0R-5dkxA:
7.70
3ko0T-5dkxA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU A 281
PHE A 272
ILE A 653
PHE A 334
 None
 1.01A 3ko0S-5dkxA:
undetectable		 3ko0S-5dkxA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 THR A 774
LEU A 641
ALA A 643
SER A 644
 None
 0.94A 3kp6A-5dkxA:
undetectable		 3kp6A-5dkxA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		8 / 12 ASP A 443
ILE A 444
ILE A 480
TRP A 517
ASP A 556
MET A 557
PHE A 666
HIS A 691
 TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.62A 3l4wA-5dkxA:
39.8		 3l4wA-5dkxA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ASP A 443
ILE A 444
ILE A 480
TRP A 554
ASP A 556
MET A 557
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 (-4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.39A 3l4wA-5dkxA:
39.8		 3l4wA-5dkxA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 TRP A 942
ALA A 945
VAL A 964
 None
 1.02A 3l8lA-5dkxA:
undetectable
3l8lB-5dkxA:
undetectable		 3l8lA-5dkxA:
1.66
3l8lB-5dkxA:
1.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ASP A  53
ARG A  49
ALA A  52
 None
 0.69A 3mbgC-5dkxA:
undetectable		 3mbgC-5dkxA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 863
ARG A 611
LEU A 861
THR A 766
ILE A 763
 None
 1.37A 3mnoA-5dkxA:
undetectable		 3mnoA-5dkxA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 863
ARG A 611
LEU A 861
THR A 766
ILE A 763
 None
 1.34A 3mnpA-5dkxA:
undetectable		 3mnpA-5dkxA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		11 / 12 ASP A 303
ASP A 443
ILE A 444
ILE A 480
TRP A 517
ASP A 556
ARG A 617
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.42A 3phaA-5dkxA:
39.8		 3phaA-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ASP A 443
ILE A 444
ILE A 480
TRP A 517
ASP A 482
 TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
None
 1.26A 3phaA-5dkxA:
39.8		 3phaA-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ASP A 303
ASP A 443
ILE A 444
ILE A 480
TRP A 517
ASP A 556
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.39A 3phaB-5dkxA:
42.9		 3phaB-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ASP A 443
ILE A 444
ILE A 480
TRP A 517
ASP A 482
 TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
None
 1.24A 3phaB-5dkxA:
42.9		 3phaB-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ASP A 633
ASP A 482
ILE A 480
ILE A 444
ASP A 303
 TRS  A1001 (-2.8A)
None
None
TRS  A1001 ( 4.1A)
None
 1.25A 3phaB-5dkxA:
42.9		 3phaB-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ASP A 303
ASP A 443
ILE A 444
TRP A 517
ASP A 556
ARG A 617
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.37A 3phaC-5dkxA:
32.7		 3phaC-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ASP A 303
ASP A 443
ILE A 480
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
None
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.26A 3phaC-5dkxA:
32.7		 3phaC-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ASP A 303
ASP A 443
ILE A 444
TRP A 517
ASP A 556
MET A 557
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.32A 3phaD-5dkxA:
33.2		 3phaD-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		8 / 12 ASP A 303
ASP A 443
ILE A 480
MET A 557
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
None
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.24A 3phaD-5dkxA:
33.2		 3phaD-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		11 / 12 TRP A 415
ASP A 443
ILE A 444
ILE A 480
TRP A 517
MET A 557
ARG A 617
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.44A 3pocA-5dkxA:
35.2		 3pocA-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		9 / 12 TRP A 415
ASP A 443
ILE A 444
ILE A 480
TRP A 517
TRP A 554
TRP A 630
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-4.9A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.83A 3pocA-5dkxA:
35.2		 3pocA-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		11 / 12 TRP A 415
ASP A 443
ILE A 444
ILE A 480
TRP A 517
MET A 557
ARG A 617
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.44A 3pocB-5dkxA:
41.8		 3pocB-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		9 / 12 TRP A 415
ASP A 443
ILE A 444
ILE A 480
TRP A 517
TRP A 554
TRP A 630
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-4.9A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.86A 3pocB-5dkxA:
41.8		 3pocB-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 PHE A 658
TYR A 727
ILE A 653
LEU A 649
 None
 1.43A 3sudA-5dkxA:
undetectable		 3sudA-5dkxA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 GLN A 404
TYR A 598
LEU A 477
LYS A 476
 None
 1.28A 3sugA-5dkxA:
undetectable		 3sugA-5dkxA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		11 / 12 ASP A 303
ASP A 443
ILE A 480
TRP A 517
ASP A 556
MET A 557
ARG A 617
ASP A 633
PHE A 666
PHE A 667
HIS A 691
 None
TRS  A1001 (-2.9A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
None
TRS  A1001 (-4.0A)
 0.49A 3topA-5dkxA:
37.4		 3topA-5dkxA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ASP A 303
TRP A 517
MET A 557
ASP A 633
PHE A 666
 None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.5A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
 1.28A 3topA-5dkxA:
37.4		 3topA-5dkxA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ILE A 444
TRP A 554
TRP A 630
THR A 635
 TRS  A1001 ( 4.1A)
TRS  A1001 (-4.9A)
None
None
 0.37A 3topA-5dkxA:
37.4		 3topA-5dkxA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ASP A 303
ASP A 443
ILE A 480
TRP A 517
ASP A 556
MET A 557
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.45A 3topB-5dkxA:
37.4		 3topB-5dkxA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ILE A 444
TRP A 554
TRP A 630
PHE A 667
 TRS  A1001 ( 4.1A)
TRS  A1001 (-4.9A)
None
None
 0.37A 3topB-5dkxA:
37.5		 3topB-5dkxA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ARG A 414
ALA A 692
TRP A 415
ALA A 696
 None
 1.45A 3tx2A-5dkxA:
undetectable		 3tx2A-5dkxA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 SER A 170
PHE A 173
LYS A 166
 None
 0.99A 3u88A-5dkxA:
undetectable		 3u88A-5dkxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 THR A 341
SER A 371
LEU A 376
VAL A 110
PHE A 196
 None
 1.42A 3u9fE-5dkxA:
undetectable		 3u9fE-5dkxA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 THR A 341
SER A 371
LEU A 376
VAL A 110
PHE A 196
 None
 1.49A 3u9fN-5dkxA:
undetectable
3u9fO-5dkxA:
undetectable		 3u9fN-5dkxA:
12.87
3u9fO-5dkxA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ASN A 558
GLN A 624
TYR A 598
PRO A 483
 None
 1.10A 3ugrA-5dkxA:
3.6		 3ugrA-5dkxA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		8 / 12 ASP A 303
ASP A 443
ILE A 444
MET A 557
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.44A 3w37A-5dkxA:
46.0		 3w37A-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ASP A 303
ASP A 443
ILE A 480
TRP A 554
ASP A 556
MET A 557
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
None
TRS  A1001 (-4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.31A 3w37A-5dkxA:
46.0		 3w37A-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 TRP A 415
ILE A 444
TRP A 517
TRP A 630
 None
TRS  A1001 ( 4.1A)
TRS  A1001 ( 4.9A)
None
 0.40A 3w37A-5dkxA:
46.0		 3w37A-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ASP A 303
ASP A 443
ILE A 444
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.42A 3welA-5dkxA:
46.5		 3welA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		9 / 12 ASP A 303
ASP A 443
ILE A 480
TRP A 554
ASP A 556
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
None
TRS  A1001 (-4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.31A 3welA-5dkxA:
46.5		 3welA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ASP A 303
TRP A 415
ASP A 633
PHE A 667
HIS A 693
 None
None
TRS  A1001 (-2.8A)
None
None
 1.41A 3welA-5dkxA:
46.5		 3welA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 6 TRP A 415
ILE A 444
TRP A 517
MET A 557
TRP A 630
 None
TRS  A1001 ( 4.1A)
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.5A)
None
 0.38A 3welA-5dkxA:
46.5		 3welA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		9 / 12 ASP A 303
ASP A 443
ILE A 444
ASP A 556
MET A 557
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.33A 3wemA-5dkxA:
42.7		 3wemA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		8 / 12 ASP A 303
ASP A 443
ILE A 480
MET A 557
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
None
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.33A 3wemA-5dkxA:
42.7		 3wemA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 TRP A 415
TRP A 517
TRP A 554
TRP A 630
 None
TRS  A1001 ( 4.9A)
TRS  A1001 (-4.9A)
None
 0.51A 3wemA-5dkxA:
42.7		 3wemA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ASP A 303
ASP A 443
ILE A 444
TRP A 554
ASP A 556
MET A 557
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
TRS  A1001 (-4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.32A 3wenA-5dkxA:
45.9		 3wenA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		8 / 12 ASP A 303
ASP A 443
ILE A 480
MET A 557
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
None
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.34A 3wenA-5dkxA:
45.9		 3wenA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		9 / 12 ASP A 303
ASP A 443
ILE A 444
TRP A 554
ASP A 556
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
TRS  A1001 (-4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.31A 3weoA-5dkxA:
38.8		 3weoA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ASP A 303
ASP A 443
ILE A 480
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
None
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.36A 3weoA-5dkxA:
38.8		 3weoA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ASP A 303
TRP A 415
ASP A 633
PHE A 667
HIS A 693
 None
None
TRS  A1001 (-2.8A)
None
None
 1.42A 3weoA-5dkxA:
38.8		 3weoA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 6 TRP A 415
ILE A 480
TRP A 517
MET A 557
TRP A 630
 None
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.5A)
None
 0.41A 3weoA-5dkxA:
38.7		 3weoA-5dkxA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		6 / 12 ASP A 443
ILE A 444
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.36A 4b9zA-5dkxA:
36.2		 4b9zA-5dkxA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ASP A 443
ILE A 480
ASP A 556
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 TRS  A1001 (-2.9A)
None
TRS  A1001 (-3.2A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.36A 4b9zA-5dkxA:
36.2		 4b9zA-5dkxA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ARG A 879
HIS A 878
GLU A 894
ASP A 892
 None
 1.47A 4cevA-5dkxA:
undetectable
4cevB-5dkxA:
undetectable		 4cevA-5dkxA:
14.39
4cevB-5dkxA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_B_GAIB408_0
(PROTEIN (ARGINASE))		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ARG A 879
HIS A 878
GLU A 894
ASP A 892
 None
 1.45A 4cevB-5dkxA:
undetectable
4cevC-5dkxA:
undetectable		 4cevB-5dkxA:
14.39
4cevC-5dkxA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ASP A 892
ARG A 879
HIS A 878
GLU A 894
 None
 1.44A 4cevA-5dkxA:
undetectable
4cevC-5dkxA:
undetectable		 4cevA-5dkxA:
14.39
4cevC-5dkxA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ARG A 879
HIS A 878
GLU A 894
ASP A 892
 None
 1.46A 4cevD-5dkxA:
undetectable
4cevE-5dkxA:
undetectable		 4cevD-5dkxA:
14.39
4cevE-5dkxA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ARG A 879
HIS A 878
GLU A 894
ASP A 892
 None
 1.45A 4cevE-5dkxA:
undetectable
4cevF-5dkxA:
undetectable		 4cevE-5dkxA:
14.39
4cevF-5dkxA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF412_0
(PROTEIN (ARGINASE))		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ASP A 892
ARG A 879
HIS A 878
GLU A 894
 None
 1.46A 4cevD-5dkxA:
undetectable
4cevF-5dkxA:
undetectable		 4cevD-5dkxA:
14.39
4cevF-5dkxA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 9 ALA A 733
ALA A 394
GLY A 398
GLY A 655
ILE A 390
 None
 1.09A 4eatB-5dkxA:
2.6		 4eatB-5dkxA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 VAL A 100
ALA A  81
SER A 183
LEU A 261
VAL A 110
 None
 1.45A 4eilA-5dkxA:
undetectable		 4eilA-5dkxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 VAL A 100
ALA A  81
SER A 183
LEU A 261
VAL A 110
 None
 1.43A 4eilB-5dkxA:
undetectable		 4eilB-5dkxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 VAL A 100
ALA A  81
SER A 183
LEU A 261
VAL A 110
 None
 1.42A 4eilC-5dkxA:
undetectable		 4eilC-5dkxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 VAL A 100
ALA A  81
SER A 183
LEU A 261
VAL A 110
 None
 1.45A 4eilE-5dkxA:
undetectable		 4eilE-5dkxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A 774
LEU A 641
ALA A 643
SER A 644
TYR A 685
 None
 1.26A 4ejwA-5dkxA:
undetectable		 4ejwA-5dkxA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 VAL A 100
ALA A  81
SER A 183
LEU A 261
VAL A 110
 None
 1.45A 4kyaA-5dkxA:
undetectable		 4kyaA-5dkxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 VAL A 100
ALA A  81
SER A 183
LEU A 261
VAL A 110
 None
 1.43A 4kyaC-5dkxA:
undetectable		 4kyaC-5dkxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 VAL A 100
ALA A  81
SER A 183
LEU A 261
VAL A 110
 None
 1.43A 4kyaE-5dkxA:
undetectable		 4kyaE-5dkxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 VAL A 100
ALA A  81
SER A 183
LEU A 261
VAL A 110
 None
 1.42A 4kyaG-5dkxA:
undetectable		 4kyaG-5dkxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 HIS A 484
TRP A 554
SER A 521
 None
TRS  A1001 (-4.9A)
None
 1.19A 4lrhD-5dkxA:
undetectable		 4lrhD-5dkxA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ASP A 556
ASN A 558
ALA A 618
ASP A 633
 TRS  A1001 (-3.2A)
None
None
TRS  A1001 (-2.8A)
 1.19A 4mdbA-5dkxA:
undetectable		 4mdbA-5dkxA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 SER A 170
ASP A 189
ASP A 328
 None
 0.89A 4mwzA-5dkxA:
undetectable		 4mwzA-5dkxA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY A 317
ASN A 301
PHE A 656
ASN A 558
GLY A 590
 None
 1.17A 4n09A-5dkxA:
undetectable		 4n09A-5dkxA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ASP A 482
TYR A 452
TRP A 554
 None
None
TRS  A1001 (-4.9A)
 1.33A 4p7nA-5dkxA:
3.8		 4p7nA-5dkxA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ASP A 864
GLU A 894
SER A 407
 None
 0.83A 5bw4B-5dkxA:
undetectable		 5bw4B-5dkxA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 GLU A 372
TRP A 342
ASN A 587
 None
 1.12A 5dv4A-5dkxA:
undetectable		 5dv4A-5dkxA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 196
VAL A 380
ILE A 274
PHE A 265
 None
 0.91A 5hw8H-5dkxA:
undetectable		 5hw8H-5dkxA:
9.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEF_A_NBVA1005_1
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		11 / 12 TRP A 415
ASP A 443
ILE A 444
ILE A 480
TRP A 554
ASP A 556
MET A 557
PHE A 563
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 (-4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.36A 5iefA-5dkxA:
50.4		 5iefA-5dkxA:
43.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEF_A_NBVA1005_2
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 ARG A 617
TRP A 630
ASP A 662
ARG A 689
 TRS  A1001 (-4.0A)
None
None
None
 0.00A 5iefA-5dkxA:
50.4		 5iefA-5dkxA:
43.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PHE A 186
ARG A 109
THR A  99
LEU A  98
 None
 0.82A 5iy5N-5dkxA:
undetectable
5iy5W-5dkxA:
undetectable		 5iy5N-5dkxA:
18.91
5iy5W-5dkxA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 GLY A 514
SER A 521
GLY A 519
ASN A 564
 None
 0.83A 5k4pA-5dkxA:
undetectable		 5k4pA-5dkxA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 TRP A 415
ASP A 443
ILE A 480
TRP A 517
TRP A 554
ASP A 556
MET A 557
TRP A 630
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.77A 5nn6A-5dkxA:
48.3		 5nn6A-5dkxA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 TRP A 415
ASP A 443
ILE A 480
TRP A 554
ASP A 556
MET A 557
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
None
TRS  A1001 (-4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.61A 5nn6A-5dkxA:
48.3		 5nn6A-5dkxA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		6 / 12 ASP A 303
ASP A 443
ILE A 444
ARG A 617
ASP A 633
PHE A 666
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
 1.44A 5nn8A-5dkxA:
33.1		 5nn8A-5dkxA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ASP A 303
ASP A 443
ILE A 480
TRP A 517
TRP A 554
ASP A 556
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.43A 5nn8A-5dkxA:
33.1		 5nn8A-5dkxA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ASP A 303
ASP A 662
ASP A 633
ASP A 556
HIS A 691
 None
None
TRS  A1001 (-2.8A)
TRS  A1001 (-3.2A)
TRS  A1001 (-4.0A)
 1.48A 5nn8A-5dkxA:
33.1		 5nn8A-5dkxA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 HIS A 576
HIS A 582
HIS A 586
 None
 0.94A 5oexA-5dkxA:
2.4		 5oexA-5dkxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 10 TRP A 554
ASP A 556
ARG A 617
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 TRS  A1001 (-4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.55A 5x7pA-5dkxA:
17.0		 5x7pA-5dkxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ILE A 184
PHE A 196
ARG A 109
THR A 107
 None
 1.22A 5z84N-5dkxA:
undetectable
5z84W-5dkxA:
undetectable		 5z84N-5dkxA:
18.91
5z84W-5dkxA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 TRP A 335
ILE A 333
TRP A 141
ALA A 339
ALA A 138
 None
 1.49A 5zjiB-5dkxA:
undetectable		 5zjiB-5dkxA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 9 VAL A 100
ILE A 263
LEU A 261
ARG A 109
ASP A 377
 None
 1.43A 6c2mC-5dkxA:
undetectable		 6c2mC-5dkxA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		6 / 12 ASP A 303
ILE A 480
MET A 557
ARG A 617
PHE A 666
HIS A 691
 None
None
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.09A 6c9xA-5dkxA:
34.0		 6c9xA-5dkxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		11 / 12 ASP A 303
TRP A 415
ILE A 444
ILE A 480
TRP A 517
ASP A 556
MET A 557
ARG A 617
TRP A 630
PHE A 666
HIS A 691
 None
None
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.45A 6c9xA-5dkxA:
34.0		 6c9xA-5dkxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		8 / 12 TRP A 415
ILE A 444
ILE A 480
TRP A 517
TRP A 554
TRP A 630
PHE A 666
HIS A 691
 None
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-4.9A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.86A 6c9xA-5dkxA:
34.0		 6c9xA-5dkxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		6 / 12 ASP A 303
ILE A 480
MET A 557
ARG A 617
PHE A 666
HIS A 691
 None
None
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.08A 6c9xB-5dkxA:
39.9		 6c9xB-5dkxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		11 / 12 ASP A 303
TRP A 415
ILE A 444
ILE A 480
TRP A 517
ASP A 556
MET A 557
ARG A 617
TRP A 630
PHE A 666
HIS A 691
 None
None
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.46A 6c9xB-5dkxA:
39.9		 6c9xB-5dkxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		8 / 12 TRP A 415
ILE A 444
ILE A 480
TRP A 517
TRP A 554
TRP A 630
PHE A 666
HIS A 691
 None
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-4.9A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.87A 6c9xB-5dkxA:
39.9		 6c9xB-5dkxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ILE A 444
ILE A 480
TRP A 517
ASP A 556
MET A 557
ARG A 617
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.36A 6c9zA-5dkxA:
32.9		 6c9zA-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ILE A 444
ILE A 480
TRP A 517
TRP A 554
TRP A 630
PHE A 666
HIS A 691
 TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-4.9A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.89A 6c9zA-5dkxA:
32.9		 6c9zA-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ASP A 303
ILE A 444
ILE A 480
TRP A 517
ASP A 556
MET A 557
ARG A 617
TRP A 630
PHE A 666
HIS A 691
 None
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.39A 6c9zB-5dkxA:
33.8		 6c9zB-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ILE A 444
ILE A 480
TRP A 517
TRP A 554
TRP A 630
PHE A 666
HIS A 691
 TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-4.9A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.88A 6c9zB-5dkxA:
33.8		 6c9zB-5dkxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		8 / 12 ASP A 443
ILE A 480
ASP A 556
MET A 557
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 TRS  A1001 (-2.9A)
None
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.28A 6ca1A-5dkxA:
32.9		 6ca1A-5dkxA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		11 / 12 TRP A 415
ASP A 443
ILE A 444
ILE A 480
ASP A 556
MET A 557
ARG A 617
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.49A 6ca1A-5dkxA:
32.9		 6ca1A-5dkxA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		8 / 12 TRP A 415
ASP A 443
ILE A 444
ILE A 480
TRP A 554
TRP A 630
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 (-4.9A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.81A 6ca1A-5dkxA:
32.9		 6ca1A-5dkxA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		8 / 12 ASP A 443
ILE A 480
ASP A 556
MET A 557
ARG A 617
ASP A 633
PHE A 666
HIS A 691
 TRS  A1001 (-2.9A)
None
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.31A 6ca1B-5dkxA:
33.0		 6ca1B-5dkxA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		11 / 12 TRP A 415
ASP A 443
ILE A 444
ILE A 480
ASP A 556
MET A 557
ARG A 617
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.46A 6ca1B-5dkxA:
33.0		 6ca1B-5dkxA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		8 / 12 TRP A 415
ASP A 443
ILE A 444
ILE A 480
TRP A 554
TRP A 630
PHE A 666
HIS A 691
 None
TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 (-4.9A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.79A 6ca1B-5dkxA:
33.0		 6ca1B-5dkxA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ASP A 443
ILE A 444
ILE A 480
ASP A 556
MET A 557
ARG A 617
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.46A 6ca3A-5dkxA:
34.0		 6ca3A-5dkxA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ASP A 443
ILE A 444
ILE A 480
TRP A 554
TRP A 630
PHE A 666
HIS A 691
 TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 (-4.9A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.86A 6ca3A-5dkxA:
34.0		 6ca3A-5dkxA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		10 / 12 ASP A 443
ILE A 444
ILE A 480
ASP A 556
MET A 557
ARG A 617
TRP A 630
ASP A 633
PHE A 666
HIS A 691
 TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-2.8A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.46A 6ca3B-5dkxA:
34.3		 6ca3B-5dkxA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ASP A 443
ILE A 444
ILE A 480
TRP A 517
ASP A 556
PHE A 666
HIS A 691
 TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.74A 6ca3B-5dkxA:
34.3		 6ca3B-5dkxA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		7 / 12 ASP A 443
ILE A 444
ILE A 480
TRP A 554
TRP A 630
PHE A 666
HIS A 691
 TRS  A1001 (-2.9A)
TRS  A1001 ( 4.1A)
None
TRS  A1001 (-4.9A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.85A 6ca3B-5dkxA:
34.3		 6ca3B-5dkxA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ASP A 427
GLN A 412
VAL A 426
ALA A 838
 None
 0.95A 6djzB-5dkxA:
undetectable		 6djzB-5dkxA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ALA A 621
PHE A 619
GLN A 651
 None
 0.76A 6eceA-5dkxA:
undetectable		 6eceA-5dkxA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 PHE A 563
PRO A 560
MET A 557
VAL A 568
 None
None
TRS  A1001 (-3.5A)
None
 1.34A 6ekzA-5dkxA:
undetectable		 6ekzA-5dkxA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 LEU A 769
ASP A 787
PRO A 786
ARG A 822
 None
 1.11A 6fgdA-5dkxA:
undetectable		 6fgdA-5dkxA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 SER A 561
VAL A 562
ASN A 564
PRO A 518
 None
 1.08A 6fi4A-5dkxA:
3.0
6fi4B-5dkxA:
undetectable		 6fi4A-5dkxA:
12.89
6fi4B-5dkxA:
1.16