SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dl5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 GLU A 130
TYR A 291
GLY A 292
GLY A 297
ALA A 167
 None
 1.23A 1httC-5dl5A:
undetectable		 1httC-5dl5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 GLU A 130
TYR A 291
GLY A 292
GLY A 297
ALA A 167
 None
 1.24A 1httD-5dl5A:
undetectable		 1httD-5dl5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 LEU A 117
LEU A 195
ALA A 235
ALA A 200
VAL A 177
 None
 1.24A 1kt4A-5dl5A:
undetectable		 1kt4A-5dl5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		3 / 3 GLN A 299
ILE A 301
TYR A 302
 None
 0.76A 1vifA-5dl5A:
undetectable		 1vifA-5dl5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		4 / 6 TYR A 397
ASP A 310
PHE A 311
GLU A 361
 None
 1.39A 2dttB-5dl5A:
0.4
2dttC-5dl5A:
1.3		 2dttB-5dl5A:
11.22
2dttC-5dl5A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 PHE A 132
LEU A 120
VAL A 119
SER A 300
VAL A 148
 None
 1.39A 2hc4A-5dl5A:
undetectable		 2hc4A-5dl5A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 GLY A  58
GLY A 111
GLY A  97
THR A 112
THR A 153
 None
 1.16A 2wa2A-5dl5A:
undetectable		 2wa2A-5dl5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 ILE A 312
ILE A 301
ASP A 310
PHE A 298
TYR A 397
 None
 1.34A 2ya7A-5dl5A:
undetectable		 2ya7A-5dl5A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		3 / 3 TYR A 205
TYR A 289
ILE A 262
 None
 0.78A 3eteA-5dl5A:
undetectable
3eteB-5dl5A:
undetectable		 3eteA-5dl5A:
22.56
3eteB-5dl5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		4 / 8 VAL A 287
PHE A 231
HIS A 236
TYR A 238
 None
 0.89A 3fhxB-5dl5A:
undetectable		 3fhxB-5dl5A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		5 / 10 TYR A 238
ASN A 260
PHE A 231
GLY A 292
ASN A 294
 None
 1.33A 3r6wA-5dl5A:
undetectable
3r6wB-5dl5A:
undetectable		 3r6wA-5dl5A:
18.62
3r6wB-5dl5A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		4 / 8 ASP A 155
ASP A 296
ASP A 310
GLU A 130
 None
 0.86A 4gkhC-5dl5A:
undetectable
4gkhK-5dl5A:
undetectable		 4gkhC-5dl5A:
21.08
4gkhK-5dl5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		4 / 8 ASP A 155
ASP A 296
ASP A 310
GLU A 130
 None
 0.87A 4gkiE-5dl5A:
undetectable
4gkiG-5dl5A:
undetectable		 4gkiE-5dl5A:
21.08
4gkiG-5dl5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		4 / 6 LEU A 220
ALA A 270
LEU A 214
THR A 271
 None
 1.04A 4ikiB-5dl5A:
undetectable		 4ikiB-5dl5A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		3 / 3 SER A  66
ASP A  64
GLN A 156
 None
 0.94A 4oltA-5dl5A:
undetectable
4oltB-5dl5A:
undetectable		 4oltA-5dl5A:
22.12
4oltB-5dl5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		4 / 6 GLU A 361
TYR A 344
GLU A 359
GLU A 316
 None
 1.28A 4r87H-5dl5A:
undetectable		 4r87H-5dl5A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		4 / 6 PHE A 224
LEU A 303
ASN A 305
PRO A 304
 None
 0.97A 4yv5B-5dl5A:
undetectable		 4yv5B-5dl5A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		4 / 6 PHE A 224
LEU A 303
ASN A 305
PRO A 304
 None
 1.00A 4yv5A-5dl5A:
undetectable		 4yv5A-5dl5A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 SER A  37
THR A  35
ILE A 312
ASP A 159
ARG A 405
 None
None
None
None
C8E  A 501 (-3.0A)
 1.21A 4zjqD-5dl5A:
undetectable		 4zjqD-5dl5A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		4 / 7 ARG A 203
ASP A 310
ILE A 312
TYR A 289
 None
 1.33A 5a06B-5dl5A:
undetectable		 5a06B-5dl5A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		4 / 5 GLY A 313
TYR A 387
TYR A 397
GLY A 395
 None
 1.07A 5ayfA-5dl5A:
undetectable		 5ayfA-5dl5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		4 / 6 SER A  37
GLY A  65
ASP A  64
ARG A  94
 None
C8E  A 502 (-3.9A)
None
None
 0.91A 5cdpA-5dl5A:
undetectable
5cdpB-5dl5A:
undetectable		 5cdpA-5dl5A:
21.76
5cdpB-5dl5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 GLU A 130
TYR A 291
GLY A 292
GLY A 297
ALA A 167
 None
 1.20A 5e3iA-5dl5A:
undetectable		 5e3iA-5dl5A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		5 / 11 GLU A 130
TYR A 291
GLY A 292
GLY A 297
ALA A 167
 None
 1.19A 5e3iB-5dl5A:
undetectable		 5e3iB-5dl5A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 GLY A  76
TYR A 291
ILE A 262
TYR A 289
PHE A 298
 C8E  A 501 (-3.4A)
None
None
None
None
 1.23A 5eslA-5dl5A:
undetectable		 5eslA-5dl5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		4 / 8 GLN A 293
ILE A 312
ASP A 310
GLY A 292
 None
 1.05A 5hwaA-5dl5A:
undetectable		 5hwaA-5dl5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5dl5 MEMBRANE PROTEIN
(Acinetobacter
baumannii) 		3 / 3 ARG A  26
PHE A 298
ARG A 126
 C8E  A 501 (-2.9A)
None
C8E  A 501 (-3.9A)
 1.17A 5y9yA-5dl5A:
undetectable		 5y9yA-5dl5A:
20.95