SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dlb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		3 / 3 ARG A  87
THR A 229
VAL A 217
 None
 0.87A 1hxbA-5dlbA:
undetectable		 1hxbA-5dlbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		4 / 6 GLU A 184
ARG A 200
ASP A 191
GLY A 194
 None
SO4  A 304 ( 4.6A)
None
None
 0.94A 1n13H-5dlbA:
undetectable
1n13K-5dlbA:
undetectable		 1n13H-5dlbA:
14.95
1n13K-5dlbA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		4 / 7 ASP A 191
GLY A 194
GLU A 184
ARG A 200
 None
None
None
SO4  A 304 ( 4.6A)
 0.93A 1n13G-5dlbA:
undetectable
1n13J-5dlbA:
undetectable		 1n13G-5dlbA:
11.41
1n13J-5dlbA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		3 / 3 ARG A  87
THR A 229
VAL A 217
 None
 0.84A 2qakA-5dlbA:
undetectable		 2qakA-5dlbA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		4 / 7 TRP A  83
LEU A  84
TRP A 283
THR A 229
 None
 1.24A 3dzgB-5dlbA:
undetectable		 3dzgB-5dlbA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		4 / 6 VAL A 134
VAL A 125
ILE A  74
ARG A 102
 None
 1.14A 3mssA-5dlbA:
undetectable		 3mssA-5dlbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		4 / 6 VAL A 134
VAL A 125
ILE A  74
ARG A 102
 None
 1.09A 3pyyA-5dlbA:
undetectable		 3pyyA-5dlbA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		5 / 12 ILE A 235
LEU A 147
LEU A 233
ILE A 271
ALA A 270
 None
 0.97A 3vrmA-5dlbA:
undetectable		 3vrmA-5dlbA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		5 / 10 SER A 248
ALA A 270
LEU A 274
GLY A 232
ALA A 109
 None
 1.39A 4fe1A-5dlbA:
undetectable
4fe1J-5dlbA:
undetectable		 4fe1A-5dlbA:
18.98
4fe1J-5dlbA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		4 / 8 GLY A  64
VAL A  65
PHE A  17
PHE A  47
 None
 0.94A 4fglD-5dlbA:
undetectable		 4fglD-5dlbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		5 / 12 ILE A 235
ALA A 270
THR A 124
VAL A 126
LEU A 151
 None
 1.32A 4qynA-5dlbA:
0.9		 4qynA-5dlbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		5 / 12 ILE A 235
ALA A 270
THR A 124
VAL A 126
LEU A 151
 None
 1.28A 4qzuA-5dlbA:
undetectable		 4qzuA-5dlbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		5 / 12 LEU A 128
VAL A 105
VAL A 214
TYR A 213
SER A 212
 None
None
None
GOL  A 305 (-3.7A)
None
 1.46A 5v1tA-5dlbA:
undetectable		 5v1tA-5dlbA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		4 / 6 SER A 257
GLU A 215
ARG A  87
ASP A  85
 SCN  A 314 ( 2.9A)
None
None
None
 1.24A 5zw4A-5dlbA:
undetectable		 5zw4A-5dlbA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 5dlb CHAPERONE ESPG3
(Mycobacterium
marinum) 		3 / 3 ARG A 249
GLY A 253
GLU A 254
 None
 0.43A 6fgdA-5dlbA:
undetectable		 6fgdA-5dlbA:
20.64