SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  19
GLY A  18
LEU A  17
GLY A 226
LEU A 248
 None
None
None
PO4  A 301 (-3.5A)
None
 1.05A 1fduA-5dlcA:
undetectable		 1fduA-5dlcA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A  19
GLY A  52
THR A  78
ILE A  53
 None
 0.65A 1gtnC-5dlcA:
undetectable
1gtnD-5dlcA:
undetectable		 1gtnC-5dlcA:
13.67
1gtnD-5dlcA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  52
ALA A  45
THR A  78
ILE A  53
ALA A  48
 None
 0.99A 1gtnM-5dlcA:
undetectable
1gtnN-5dlcA:
undetectable		 1gtnM-5dlcA:
13.67
1gtnN-5dlcA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  85
GLU A  83
VAL A 105
HIS A  63
ARG A  62
 None
 1.12A 1jdvE-5dlcA:
undetectable
1jdvF-5dlcA:
undetectable		 1jdvE-5dlcA:
22.14
1jdvF-5dlcA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 8 VAL A  86
LEU A 118
SER A 155
VAL A 158
 None
 0.98A 1jtvA-5dlcA:
undetectable		 1jtvA-5dlcA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 ASP A  51
ARG A  14
LEU A 250
ILE A 229
ILE A  53
 None
 0.94A 1q6iB-5dlcA:
undetectable		 1q6iB-5dlcA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 8 MET A  90
PRO A  99
SER A 139
VAL A  55
 None
 1.15A 2qd3A-5dlcA:
undetectable		 2qd3A-5dlcA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 7 ASN A  20
ALA A  42
ALA A  41
ALA A  45
 None
 0.58A 3a2qA-5dlcA:
undetectable		 3a2qA-5dlcA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 142
GLY A 203
VAL A 214
ILE A 220
ASN A 221
 None
 1.14A 3jb2A-5dlcA:
undetectable		 3jb2A-5dlcA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 7 MET A  90
PRO A  99
SER A 139
VAL A  55
 None
 1.18A 4kmmA-5dlcA:
undetectable		 4kmmA-5dlcA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 170
GLY A 203
GLY A 205
LEU A 165
ILE A 220
 None
None
PO4  A 301 (-3.8A)
None
None
 1.01A 4krhA-5dlcA:
undetectable		 4krhA-5dlcA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 170
GLY A 203
GLY A 205
LEU A 165
ILE A 220
 None
None
PO4  A 301 (-3.8A)
None
None
 1.03A 4krhB-5dlcA:
undetectable		 4krhB-5dlcA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 150
ASP A 119
VAL A 131
ALA A 130
 None
 0.99A 4nkxA-5dlcA:
undetectable		 4nkxA-5dlcA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 6 HIS A  23
VAL A 230
LEU A  27
THR A  26
 None
 1.07A 5ogjA-5dlcA:
undetectable		 5ogjA-5dlcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 6 HIS A  23
VAL A 230
LEU A  27
THR A  26
 None
 1.06A 5ogjB-5dlcA:
undetectable		 5ogjB-5dlcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 5 HIS A  23
VAL A 230
LEU A  27
THR A  26
 None
 1.07A 5ohhA-5dlcA:
undetectable		 5ohhA-5dlcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 6 HIS A  23
VAL A 230
LEU A  27
THR A  26
 None
 1.07A 5ohhB-5dlcA:
undetectable		 5ohhB-5dlcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 ILE A  97
ILE A  64
LEU A  72
HIS A  56
VAL A  55
 None
 1.07A 5twjB-5dlcA:
undetectable		 5twjB-5dlcA:
25.57