SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dlj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5dlj CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS2
(Escherichia
coli) 		5 / 12 ILE F  47
SER F   2
LEU F  23
ILE F  43
THR F  72
 None
 0.97A 1dhiA-5dljF:
undetectable		 1dhiA-5dljF:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Escherichia
coli) 		5 / 12 PHE D 215
LEU D 213
ALA D 203
LEU D  99
LEU D 272
 None
 1.19A 1og5B-5dljD:
undetectable		 1og5B-5dljD:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Escherichia
coli) 		5 / 9 VAL D 271
LEU D 122
PHE D 215
PHE D 124
LEU D 267
 None
 1.44A 1wrkA-5dljD:
undetectable
1wrkB-5dljD:
undetectable		 1wrkA-5dljD:
14.17
1wrkB-5dljD:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Escherichia
coli) 		5 / 12 GLN D  90
ALA D  94
ALA D  50
VAL D  15
LEU D 272
 None
 1.07A 3b0wB-5dljD:
undetectable		 3b0wB-5dljD:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Escherichia
coli) 		5 / 9 ASP D 221
GLY D 205
ILE D 204
ILE D 268
ILE D 219
 None
 1.02A 3s45A-5dljD:
undetectable		 3s45A-5dljD:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Escherichia
coli) 		5 / 12 GLN D  90
GLY D  89
ILE D 265
ALA D 193
ALA D 194
 None
 1.07A 3sueA-5dljD:
undetectable		 3sueA-5dljD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Escherichia
coli) 		4 / 7 PHE D 120
VAL D 207
GLY D 139
PHE D 124
 None
 0.95A 4ejjB-5dljD:
undetectable		 4ejjB-5dljD:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Escherichia
coli) 		5 / 12 LEU D 261
LEU D 264
ILE D 265
ILE D 268
PHE D 215
 None
 1.21A 5uanB-5dljD:
undetectable		 5uanB-5dljD:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WHY_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 5dlj CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS2
(Escherichia
coli) 		5 / 11 TYR F  31
ARG F  16
THR F   8
VAL F   6
VAL F   5
 None
 1.33A 5whyA-5dljF:
undetectable		 5whyA-5dljF:
10.50