SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dlk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 5dlk TQAA
(Penicillium
aethiopicum) 		3 / 3 GLU A 124
LYS A 121
VAL A 122
 None
 0.91A 1l2iA-5dlkA:
undetectable		 1l2iA-5dlkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_A_ADNA252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 5dlk TQAA
(Penicillium
aethiopicum) 		5 / 9 GLY A 154
THR A 101
ILE A  63
SER A 178
GLN A 181
 None
 1.20A 2a8tA-5dlkA:
undetectable		 2a8tA-5dlkA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_A_ADNA252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 5dlk TQAA
(Penicillium
aethiopicum) 		5 / 9 GLY A 154
THR A 101
ILE A  63
SER A 180
GLN A 181
 None
 1.44A 2a8tA-5dlkA:
undetectable		 2a8tA-5dlkA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5dlk TQAA
(Penicillium
aethiopicum) 		4 / 6 LEU A 213
TYR A 212
ARG A 314
GLY A 313
 None
 0.87A 2du8B-5dlkA:
undetectable		 2du8B-5dlkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5dlk TQAA
(Penicillium
aethiopicum) 		4 / 7 ARG A 335
LEU A 334
HIS A 353
THR A 337
 None
 1.04A 2f78A-5dlkA:
undetectable		 2f78A-5dlkA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5dlk TQAA
(Penicillium
aethiopicum) 		3 / 3 ASP A 319
ASN A 320
THR A 328
 None
 0.74A 2pymB-5dlkA:
undetectable		 2pymB-5dlkA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 5dlk TQAA
(Penicillium
aethiopicum) 		5 / 12 LEU A 350
LEU A 351
ILE A 475
ALA A 470
THR A 469
 None
 1.03A 2v0mC-5dlkA:
undetectable		 2v0mC-5dlkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 5dlk TQAA
(Penicillium
aethiopicum) 		5 / 12 LEU A 396
ILE A 187
GLY A 184
HIS A  69
HIS A 179
 None
None
None
DMS  A 507 (-4.5A)
DMS  A 507 (-4.6A)
 1.31A 3hgiA-5dlkA:
undetectable		 3hgiA-5dlkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5dlk TQAA
(Penicillium
aethiopicum) 		4 / 7 LEU A 472
VAL A 274
ILE A 461
MET A 348
 EDO  A 505 ( 4.0A)
None
None
None
 1.03A 3ik3A-5dlkA:
undetectable		 3ik3A-5dlkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5dlk TQAA
(Penicillium
aethiopicum) 		4 / 7 LEU A 472
VAL A 274
ILE A 461
MET A 348
 EDO  A 505 ( 4.0A)
None
None
None
 1.02A 3ik3B-5dlkA:
undetectable		 3ik3B-5dlkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5dlk TQAA
(Penicillium
aethiopicum) 		5 / 12 LEU A 296
THR A 356
PHE A 307
ILE A 457
ILE A 475
 None
 0.94A 3nxuB-5dlkA:
undetectable		 3nxuB-5dlkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5dlk TQAA
(Penicillium
aethiopicum) 		4 / 6 VAL A 185
ASP A 183
ALA A  58
PHE A 331
 None
 1.02A 4nedA-5dlkA:
undetectable		 4nedA-5dlkA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dlk TQAA
(Penicillium
aethiopicum) 		4 / 6 THR A 328
GLN A  59
THR A 206
HIS A  96
 None
 1.20A 4pfjB-5dlkA:
undetectable		 4pfjB-5dlkA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5dlk TQAA
(Penicillium
aethiopicum) 		4 / 5 GLN A 181
HIS A  96
ILE A 177
ILE A 187
 None
 1.21A 5dnvA-5dlkA:
undetectable		 5dnvA-5dlkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dlk TQAA
(Penicillium
aethiopicum) 		3 / 3 ARG A 159
ILE A 175
PHE A 160
 None
 0.70A 5kirA-5dlkA:
undetectable		 5kirA-5dlkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5dlk TQAA
(Penicillium
aethiopicum) 		4 / 6 LEU A 445
ALA A 450
LEU A 387
THR A 292
 None
 0.93A 6f88B-5dlkA:
undetectable		 6f88B-5dlkA:
9.92