SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dll'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		3 / 3 ASP A 436
ASP A 441
ASP A 429
 None
CL  A 915 ( 4.7A)
None
 0.72A 1eizA-5dllA:
undetectable		 1eizA-5dllA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		3 / 3 ASP A 436
ASP A 441
ASP A 429
 None
CL  A 915 ( 4.7A)
None
 0.73A 1ej0A-5dllA:
undetectable		 1ej0A-5dllA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 12 HIS A 306
GLU A 307
HIS A 310
GLU A 329
TYR A 390
 ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
ZN  A 901 (-1.6A)
None
 0.77A 1j36A-5dllA:
5.0		 1j36A-5dllA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 12 HIS A 306
GLU A 307
HIS A 310
GLU A 329
TYR A 390
 ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
ZN  A 901 (-1.6A)
None
 0.77A 1j36B-5dllA:
5.1		 1j36B-5dllA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 11 HIS A 306
GLU A 307
HIS A 310
GLU A 329
TYR A 390
 ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
ZN  A 901 (-1.6A)
None
 0.75A 1j37A-5dllA:
4.8		 1j37A-5dllA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 11 HIS A 306
GLU A 307
HIS A 310
GLU A 329
TYR A 390
 ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
ZN  A 901 (-1.6A)
None
 0.76A 1j37B-5dllA:
5.3		 1j37B-5dllA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 12 TYR A 194
LEU A 195
GLU A 307
HIS A 306
GLU A 329
 None
None
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
ZN  A 901 (-1.6A)
 1.26A 1mmkA-5dllA:
undetectable		 1mmkA-5dllA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 12 HIS A 306
GLU A 307
HIS A 310
GLU A 329
TYR A 390
 ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
ZN  A 901 (-1.6A)
None
 0.85A 1o86A-5dllA:
5.4		 1o86A-5dllA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 5 LEU A 763
ALA A 749
LEU A 745
SER A 779
 None
 1.10A 1tt6B-5dllA:
2.8		 1tt6B-5dllA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 6 LEU A 763
ALA A 749
LEU A 745
SER A 779
 None
 1.20A 1tyrA-5dllA:
undetectable		 1tyrA-5dllA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 6 LEU A 763
ALA A 749
LEU A 745
SER A 779
 None
 1.06A 1tz8C-5dllA:
undetectable
1tz8D-5dllA:
undetectable		 1tz8C-5dllA:
9.56
1tz8D-5dllA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 6 ILE A 555
VAL A 556
VAL A 637
ILE A 577
 None
 0.76A 1uwhA-5dllA:
undetectable		 1uwhA-5dllA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 8 GLU A 329
HIS A 306
HIS A 310
GLU A 307
 ZN  A 901 (-1.6A)
ZN  A 901 (-3.3A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
 0.92A 1v7zA-5dllA:
undetectable		 1v7zA-5dllA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 8 GLU A 329
HIS A 306
HIS A 310
GLU A 307
 ZN  A 901 (-1.6A)
ZN  A 901 (-3.3A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
 0.92A 1v7zB-5dllA:
undetectable		 1v7zB-5dllA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 8 GLU A 329
HIS A 306
HIS A 310
GLU A 307
 ZN  A 901 (-1.6A)
ZN  A 901 (-3.3A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
 0.93A 1v7zC-5dllA:
undetectable		 1v7zC-5dllA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 8 GLU A 329
HIS A 306
HIS A 310
GLU A 307
 ZN  A 901 (-1.6A)
ZN  A 901 (-3.3A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
 0.93A 1v7zD-5dllA:
undetectable		 1v7zD-5dllA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 8 GLU A 329
HIS A 306
HIS A 310
GLU A 307
 ZN  A 901 (-1.6A)
ZN  A 901 (-3.3A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
 0.93A 1v7zE-5dllA:
undetectable		 1v7zE-5dllA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 8 GLU A 329
HIS A 306
HIS A 310
GLU A 307
 ZN  A 901 (-1.6A)
ZN  A 901 (-3.3A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
 0.93A 1v7zF-5dllA:
undetectable		 1v7zF-5dllA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		3 / 3 LYS A 191
ASP A 169
ASN A 167
 None
 1.12A 2bm9A-5dllA:
undetectable		 2bm9A-5dllA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		6 / 12 ALA A 271
HIS A 306
GLU A 307
HIS A 310
GLU A 329
TYR A 390
 None
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
ZN  A 901 (-1.6A)
None
 0.71A 2c6nA-5dllA:
5.4		 2c6nA-5dllA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 12 HIS A 306
GLU A 307
HIS A 310
GLU A 329
TYR A 390
 ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
ZN  A 901 (-1.6A)
None
 0.82A 2c6nB-5dllA:
undetectable		 2c6nB-5dllA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 9 LEU A 101
ALA A  43
LEU A  68
LEU A  30
THR A 138
 None
NA  A 917 (-3.6A)
None
None
NA  A 917 (-3.4A)
 1.19A 2npnA-5dllA:
undetectable		 2npnA-5dllA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 6 LEU A 165
MET A 236
MET A 243
LEU A 220
 None
 1.32A 2oz7A-5dllA:
undetectable		 2oz7A-5dllA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 11 HIS A 306
GLU A 307
HIS A 310
GLU A 329
TYR A 390
 ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
ZN  A 901 (-1.6A)
None
 0.77A 2x8zA-5dllA:
6.0		 2x8zA-5dllA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 12 HIS A 306
GLU A 307
HIS A 310
GLU A 329
TYR A 390
 ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
ZN  A 901 (-1.6A)
None
 0.81A 2x91A-5dllA:
3.0		 2x91A-5dllA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 8 GLU A 329
HIS A 306
HIS A 310
GLU A 307
 ZN  A 901 (-1.6A)
ZN  A 901 (-3.3A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
 0.93A 3a6jA-5dllA:
undetectable		 3a6jA-5dllA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 7 GLU A 329
HIS A 306
HIS A 310
GLU A 307
 ZN  A 901 (-1.6A)
ZN  A 901 (-3.3A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
 0.91A 3a6jB-5dllA:
undetectable		 3a6jB-5dllA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 8 GLU A 329
HIS A 306
HIS A 310
GLU A 307
 ZN  A 901 (-1.6A)
ZN  A 901 (-3.3A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
 0.92A 3a6jC-5dllA:
undetectable		 3a6jC-5dllA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 8 GLU A 329
HIS A 306
HIS A 310
GLU A 307
 ZN  A 901 (-1.6A)
ZN  A 901 (-3.3A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
 0.95A 3a6jE-5dllA:
undetectable		 3a6jE-5dllA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 8 GLU A 329
HIS A 306
HIS A 310
GLU A 307
 ZN  A 901 (-1.6A)
ZN  A 901 (-3.3A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
 0.92A 3a6jF-5dllA:
undetectable		 3a6jF-5dllA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 5 VAL A  41
VAL A 105
THR A  28
THR A  39
 NA  A 917 (-4.6A)
NA  A 917 ( 4.1A)
None
None
 0.90A 3bjwC-5dllA:
undetectable		 3bjwC-5dllA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 5 VAL A  41
VAL A 105
THR A  28
THR A  39
 NA  A 917 (-4.6A)
NA  A 917 ( 4.1A)
None
None
 0.89A 3bjwD-5dllA:
undetectable		 3bjwD-5dllA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		3 / 3 GLU A 364
HIS A 371
THR A 386
 None
 0.89A 3hkuA-5dllA:
undetectable		 3hkuA-5dllA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		3 / 3 HIS A 306
SER A 242
ASN A 278
 ZN  A 901 (-3.3A)
None
None
 0.84A 3s8pB-5dllA:
undetectable		 3s8pB-5dllA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		3 / 3 ARG A 358
PRO A 455
PHE A 362
 None
 1.05A 3thrC-5dllA:
undetectable		 3thrC-5dllA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_C_ACTC207_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 4 LYS A 772
PRO A 771
LEU A 809
ASN A 813
 None
CL  A 905 ( 4.9A)
CL  A 905 ( 4.8A)
None
 1.48A 3tpxC-5dllA:
0.0		 3tpxC-5dllA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 5 LEU A 780
GLY A 783
MET A 802
ASN A 823
 None
 1.24A 3uq6B-5dllA:
undetectable		 3uq6B-5dllA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		3 / 3 GLN A 707
ASP A 699
GLN A 695
 None
 0.89A 4aztA-5dllA:
undetectable		 4aztA-5dllA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 12 TYR A 470
ASP A 559
GLY A 497
GLY A 503
PRO A 529
 CL  A 913 (-4.9A)
None
None
None
None
 1.03A 4blvA-5dllA:
undetectable		 4blvA-5dllA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 11 HIS A 306
GLU A 307
HIS A 310
GLU A 329
TYR A 390
 ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
ZN  A 901 (-1.6A)
None
 0.77A 4c2pA-5dllA:
5.6		 4c2pA-5dllA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 6 LEU A 763
ALA A 749
LEU A 745
SER A 779
 None
 1.06A 4d7bB-5dllA:
undetectable		 4d7bB-5dllA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		3 / 3 LYS A 159
LYS A 158
PRO A 162
 None
 1.17A 4dv1L-5dllA:
undetectable		 4dv1L-5dllA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 5 GLY A 783
GLY A 782
MET A 820
ASN A 823
 None
CL  A 903 ( 4.1A)
CL  A 903 ( 4.8A)
None
 0.91A 4fglC-5dllA:
undetectable		 4fglC-5dllA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 6 GLY A 783
GLY A 782
MET A 820
ASN A 823
 None
CL  A 903 ( 4.1A)
CL  A 903 ( 4.8A)
None
 0.98A 4fglD-5dllA:
undetectable		 4fglD-5dllA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 6 ILE A 555
ASP A 559
ARG A 535
VAL A 494
 None
None
CL  A 908 (-4.0A)
None
 1.05A 4oltA-5dllA:
undetectable		 4oltA-5dllA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 6 ILE A 555
ASP A 559
ARG A 535
VAL A 494
 None
None
CL  A 908 (-4.0A)
None
 1.04A 4oltB-5dllA:
undetectable		 4oltB-5dllA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		6 / 12 ALA A 131
GLU A 307
HIS A 310
TRP A 322
GLU A 329
TYR A 390
 None
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
None
ZN  A 901 (-1.6A)
None
 0.86A 4r7lA-5dllA:
39.0		 4r7lA-5dllA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		6 / 12 ALA A 131
HIS A 306
GLU A 307
HIS A 310
TRP A 322
GLU A 329
 None
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
ZN  A 901 (-3.3A)
None
ZN  A 901 (-1.6A)
 0.55A 4r7lA-5dllA:
39.0		 4r7lA-5dllA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 5 PHE A 534
PRO A 540
VAL A 541
PHE A 362
 None
 1.28A 4w5oA-5dllA:
2.1		 4w5oA-5dllA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 7 LYS A 672
LYS A 674
TYR A 680
LEU A 681
 None
 1.17A 4yv5A-5dllA:
undetectable		 4yv5A-5dllA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 7 LYS A 672
LYS A 674
TYR A 680
LEU A 681
 None
 1.01A 4yv5B-5dllA:
1.7		 4yv5B-5dllA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 5 PHE A 534
PRO A 540
VAL A 541
PHE A 362
 None
 1.27A 4z4cA-5dllA:
2.3		 4z4cA-5dllA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 5 PHE A 534
PRO A 540
VAL A 541
PHE A 362
 None
 1.30A 4z4dA-5dllA:
undetectable		 4z4dA-5dllA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 5 PHE A 534
PRO A 540
VAL A 541
PHE A 362
 None
 1.27A 4z4eA-5dllA:
2.4		 4z4eA-5dllA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 6 LEU A 763
ALA A 749
LEU A 745
SER A 779
 None
 1.25A 5a6iA-5dllA:
undetectable		 5a6iA-5dllA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		3 / 3 HIS A 306
SER A 242
ASN A 278
 ZN  A 901 (-3.3A)
None
None
 0.87A 5cprB-5dllA:
undetectable		 5cprB-5dllA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 12 ILE A 137
GLY A 133
ASN A 167
PHE A 196
THR A  28
 None
 1.34A 5fhzA-5dllA:
undetectable		 5fhzA-5dllA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		3 / 3 ALA A 620
GLN A 571
THR A 574
 None
 0.66A 5n0oA-5dllA:
undetectable		 5n0oA-5dllA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		3 / 3 ARG A 819
LYS A 283
ARG A 822
 None
 1.40A 6az3C-5dllA:
undetectable
6az3L-5dllA:
undetectable
6az3M-5dllA:
undetectable		 6az3C-5dllA:
6.93
6az3L-5dllA:
7.28
6az3M-5dllA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 12 ILE A 492
LEU A 533
VAL A 543
LEU A 490
THR A 454
 None
 1.21A 6b54A-5dllA:
undetectable		 6b54A-5dllA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 8 ILE A 379
THR A 386
VAL A 387
SER A 370
 None
 1.03A 6fbvC-5dllA:
undetectable		 6fbvC-5dllA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		4 / 7 TRP A 734
HIS A 736
HIS A 766
ASP A 738
 None
 1.40A 6mn4F-5dllA:
undetectable		 6mn4F-5dllA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 5dll AMINOPEPTIDASE N
(Francisella
tularensis) 		5 / 11 ILE A 279
LEU A 118
LEU A 165
ASN A 167
ALA A 200
 None
 1.28A 6r2eF-5dllA:
undetectable		 6r2eF-5dllA:
16.43