SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 PHE A 134
ILE A 143
ASN A 116
ASP A  91
GLY A  68
 None
None
None
SAH  A 301 (-2.8A)
SAH  A 301 (-3.6A)
 1.13A 1hvyA-5dlyA:
undetectable		 1hvyA-5dlyA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 11 PHE A 134
ILE A 143
ASN A 116
ASP A  91
GLY A  68
 None
None
None
SAH  A 301 (-2.8A)
SAH  A 301 (-3.6A)
 1.17A 1hvyC-5dlyA:
undetectable		 1hvyC-5dlyA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		3 / 3 HIS A 131
ASP A  91
ASN A 113
 SAH  A 301 (-3.8A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.8A)
 0.83A 1wg8B-5dlyA:
13.7		 1wg8B-5dlyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 GLY A 221
GLY A 220
LEU A 232
MET A 233
LEU A 242
 None
 0.99A 1ya4A-5dlyA:
3.0		 1ya4A-5dlyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 GLY A 221
GLY A 220
LEU A 232
MET A 233
LEU A 242
 None
 1.03A 1ya4C-5dlyA:
undetectable		 1ya4C-5dlyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 11 VAL A 160
ILE A 127
PHE A  49
LEU A  78
ASP A  66
 None
None
None
None
SAH  A 301 ( 4.7A)
 1.19A 2qeiA-5dlyA:
undetectable		 2qeiA-5dlyA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		4 / 8 TYR A  62
SER A  63
GLN A 154
SER A 152
 None
 1.15A 2xz5B-5dlyA:
undetectable
2xz5E-5dlyA:
undetectable		 2xz5B-5dlyA:
21.76
2xz5E-5dlyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 PHE A  21
GLY A  68
GLY A  70
SER A  93
ARG A  42
 SAH  A 301 ( 4.1A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.8A)
None
 1.34A 3dlcA-5dlyA:
16.3		 3dlcA-5dlyA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		3 / 3 TYR A 187
TYR A  33
GLY A 170
 None
5D7  A 300 (-4.8A)
None
 0.52A 3eteB-5dlyA:
4.0
3eteD-5dlyA:
3.8
3eteF-5dlyA:
2.2		 3eteB-5dlyA:
19.52
3eteD-5dlyA:
19.52
3eteF-5dlyA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 10 GLY A  89
ASP A  66
ILE A  67
VAL A 121
GLN A 125
 None
SAH  A 301 ( 4.7A)
None
None
None
 1.37A 3fhjA-5dlyA:
undetectable		 3fhjA-5dlyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 10 GLY A  89
ASP A  66
ILE A  67
VAL A 121
GLN A 125
 None
SAH  A 301 ( 4.7A)
None
None
None
 1.37A 3fhjB-5dlyA:
undetectable		 3fhjB-5dlyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 10 GLY A  89
ASP A  66
ILE A  67
VAL A 121
GLN A 125
 None
SAH  A 301 ( 4.7A)
None
None
None
 1.37A 3fhjC-5dlyA:
undetectable		 3fhjC-5dlyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 9 GLY A  89
ASP A  66
ILE A  67
VAL A 121
GLN A 125
 None
SAH  A 301 ( 4.7A)
None
None
None
 1.37A 3fhjD-5dlyA:
undetectable		 3fhjD-5dlyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 10 GLY A  89
ASP A  66
ILE A  67
VAL A 121
GLN A 125
 None
SAH  A 301 ( 4.7A)
None
None
None
 1.37A 3fhjE-5dlyA:
undetectable		 3fhjE-5dlyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 9 GLY A  89
ASP A  66
ILE A  67
VAL A 121
GLN A 125
 None
SAH  A 301 ( 4.7A)
None
None
None
 1.37A 3fhjF-5dlyA:
undetectable		 3fhjF-5dlyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 9 GLY A  89
ASP A  66
ILE A  67
VAL A 121
GLN A 125
 None
SAH  A 301 ( 4.7A)
None
None
None
 1.38A 3fi0F-5dlyA:
undetectable		 3fi0F-5dlyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 9 GLY A  89
ASP A  66
ILE A  67
VAL A 121
GLN A 125
 None
SAH  A 301 ( 4.7A)
None
None
None
 1.33A 3fi0L-5dlyA:
undetectable		 3fi0L-5dlyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 9 GLY A  89
ASP A  66
ILE A  67
VAL A 121
GLN A 125
 None
SAH  A 301 ( 4.7A)
None
None
None
 1.34A 3fi0M-5dlyA:
undetectable		 3fi0M-5dlyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 11 GLY A  68
GLY A  70
ASP A  91
ALA A 114
ARG A  42
 SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
None
 1.09A 3g88A-5dlyA:
11.6		 3g88A-5dlyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 11 GLY A  68
GLY A  70
ASP A  91
ALA A 114
ARG A  42
 SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
None
 1.10A 3g88B-5dlyA:
11.5		 3g88B-5dlyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 GLY A  68
GLY A  70
ASP A  91
ALA A 114
ARG A  42
 SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
None
 1.07A 3g89A-5dlyA:
11.6		 3g89A-5dlyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 11 GLY A  68
GLY A  70
ASP A  91
ALA A 114
ARG A  42
 SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
None
 1.07A 3g89B-5dlyA:
11.6		 3g89B-5dlyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 GLY A  68
GLY A  70
ASP A  91
ALA A 114
ARG A  42
 SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
None
 1.03A 3g8bA-5dlyA:
11.5		 3g8bA-5dlyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 GLY A  68
GLY A  70
ASP A  91
ALA A 114
ARG A  42
 SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
None
 1.09A 3g8bB-5dlyA:
11.0		 3g8bB-5dlyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 11 ASP A  66
GLY A  68
GLY A  70
ASP A  91
ASN A 113
 SAH  A 301 ( 4.7A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.8A)
 0.46A 4dcmA-5dlyA:
11.5		 4dcmA-5dlyA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 ILE A 130
GLY A  89
GLY A  68
ILE A 117
ALA A 114
 None
None
SAH  A 301 (-3.6A)
None
SAH  A 301 (-3.5A)
 1.02A 4kicB-5dlyA:
14.3		 4kicB-5dlyA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 GLY A  68
GLY A  70
SER A  93
ALA A 114
CYH A 133
 SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.8A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 4.4A)
 0.88A 4krhA-5dlyA:
16.0		 4krhA-5dlyA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 GLY A  68
GLY A  70
SER A  93
ALA A 114
CYH A 133
 SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.8A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 4.4A)
 0.84A 4krhB-5dlyA:
16.0		 4krhB-5dlyA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 ILE A  97
GLY A  68
GLY A  70
ILE A 130
LEU A 147
 None
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
None
None
 1.11A 4mwzA-5dlyA:
15.8		 4mwzA-5dlyA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		4 / 6 ILE A 219
GLY A 221
ILE A 264
LEU A 238
 None
 0.74A 4o8fB-5dlyA:
undetectable		 4o8fB-5dlyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 ASP A  66
LEU A  65
LEU A 147
PHE A 196
ILE A  67
 SAH  A 301 ( 4.7A)
None
None
None
None
 0.98A 4x1fA-5dlyA:
undetectable		 4x1fA-5dlyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 ASP A  66
LEU A  65
LEU A 147
PHE A 196
ILE A  67
 SAH  A 301 ( 4.7A)
None
None
None
None
 0.96A 4x1gA-5dlyA:
undetectable		 4x1gA-5dlyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 GLU A 194
GLU A 195
LEU A 200
GLY A 215
ILE A 159
 None
 1.23A 4xe5A-5dlyA:
2.1		 4xe5A-5dlyA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 ILE A 143
LEU A 200
ASP A 161
GLY A 135
ILE A 130
 None
None
5D7  A 300 (-2.8A)
5D7  A 300 (-3.5A)
None
 1.06A 5j7wD-5dlyA:
undetectable		 5j7wD-5dlyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		3 / 3 GLY A  70
ASP A  91
ASN A 113
 SAH  A 301 ( 3.7A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.8A)
 0.34A 5jglA-5dlyA:
15.1		 5jglA-5dlyA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 9 LEU A  78
ILE A  97
ILE A  67
VAL A  74
ILE A  75
 None
 1.12A 5kr2D-5dlyA:
undetectable		 5kr2D-5dlyA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		4 / 7 PHE A 134
ILE A 143
ASP A  91
GLY A  68
 None
None
SAH  A 301 (-2.8A)
SAH  A 301 (-3.6A)
 0.88A 5x5qC-5dlyA:
undetectable		 5x5qC-5dlyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		4 / 8 PHE A 134
ILE A 143
ASP A  91
GLY A  68
 None
None
SAH  A 301 (-2.8A)
SAH  A 301 (-3.6A)
 0.87A 5x5qD-5dlyA:
undetectable		 5x5qD-5dlyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 12 ASP A  66
GLY A  68
GLY A  70
VAL A  74
PHE A 129
 SAH  A 301 ( 4.7A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
None
None
 0.73A 6nj9K-5dlyA:
6.0		 6nj9K-5dlyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 10 ASP A  66
GLY A  68
GLY A  70
GLN A  73
PHE A 137
 SAH  A 301 ( 4.7A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
None
SAH  A 301 (-4.6A)
 1.04A 6nqaK-5dlyA:
8.0		 6nqaK-5dlyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML
(Bacillus
velezensis) 		5 / 10 ASP A  66
GLY A  68
GLY A  70
VAL A  74
PHE A 137
 SAH  A 301 ( 4.7A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.7A)
None
SAH  A 301 (-4.6A)
 0.85A 6nqaK-5dlyA:
8.0		 6nqaK-5dlyA:
21.28