SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 ILE A 128
ALA A 252
LEU A 189
PHE A 132
ILE A 139
 None
 1.16A 1ddrB-5dm4A:
undetectable		 1ddrB-5dm4A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 ILE A 128
ALA A 252
LEU A 189
PHE A 132
ILE A 139
 None
 1.11A 1re7A-5dm4A:
2.2		 1re7A-5dm4A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 GLY A  67
GLY A  69
MET A  73
ASP A 112
ILE A 113
 SAH  A 300 (-3.6A)
SAH  A 300 ( 3.7A)
SAH  A 300 ( 4.5A)
SAH  A 300 (-2.9A)
SAH  A 300 (-4.5A)
 0.92A 2b25A-5dm4A:
10.7		 2b25A-5dm4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 ILE A 155
ILE A 157
LEU A 198
THR A 199
LEU A 197
 None
 1.05A 2bdmA-5dm4A:
undetectable		 2bdmA-5dm4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		4 / 8 ILE A   6
ARG A 162
LEU A 189
GLU A 193
 None
 0.81A 2cdqA-5dm4A:
undetectable		 2cdqA-5dm4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 11 ASP A  65
ILE A 104
LEU A 102
ILE A  63
PHE A 108
 SAH  A 300 ( 4.4A)
None
None
None
None
 1.07A 2dg9A-5dm4A:
undetectable		 2dg9A-5dm4A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 ILE A   2
ILE A   6
GLY A 133
LEU A 250
LEU A 198
 None
None
5DA  A 302 (-3.5A)
None
None
 1.07A 3em0B-5dm4A:
undetectable		 3em0B-5dm4A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		4 / 5 LYS A 248
SER A 192
LEU A 160
SER A 188
 None
None
5DA  A 302 ( 4.5A)
5DA  A 302 (-2.8A)
 1.43A 3ijxH-5dm4A:
undetectable		 3ijxH-5dm4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 9 LEU A 134
ILE A 201
LEU A 254
ILE A 155
ILE A 126
 SAH  A 300 ( 4.3A)
None
None
None
None
 1.26A 3zosB-5dm4A:
undetectable		 3zosB-5dm4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		4 / 4 TRP A 253
LEU A 230
LEU A  54
THR A  55
 None
 1.33A 4bboD-5dm4A:
undetectable		 4bboD-5dm4A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 GLY A  67
GLY A  69
ASP A  90
ASP A 112
ILE A 113
 SAH  A 300 (-3.6A)
SAH  A 300 ( 3.7A)
SAH  A 300 (-2.8A)
SAH  A 300 (-2.9A)
SAH  A 300 (-4.5A)
 0.50A 4iv8A-5dm4A:
16.2		 4iv8A-5dm4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 GLY A  67
GLY A  69
ASP A  90
ASP A 112
ILE A 113
 SAH  A 300 (-3.6A)
SAH  A 300 ( 3.7A)
SAH  A 300 (-2.8A)
SAH  A 300 (-2.9A)
SAH  A 300 (-4.5A)
 0.51A 4iv8B-5dm4A:
16.1		 4iv8B-5dm4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 ILE A 109
GLY A  88
ILE A 126
ILE A 128
LEU A 141
 None
None
None
None
GOL  A 301 (-4.4A)
 1.01A 4mwzA-5dm4A:
16.2		 4mwzA-5dm4A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 GLY A 133
PHE A 135
ILE A 201
THR A 202
LEU A 254
 5DA  A 302 (-3.5A)
SAH  A 300 ( 4.6A)
None
None
None
 0.96A 4n49A-5dm4A:
6.8		 4n49A-5dm4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 ILE A 128
ALA A 252
LEU A 189
PHE A 132
ILE A 139
 None
 1.19A 4qlgA-5dm4A:
undetectable		 4qlgA-5dm4A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 GLY A  67
GLY A  69
ASP A  90
ILE A 113
LEU A 127
 SAH  A 300 (-3.6A)
SAH  A 300 ( 3.7A)
SAH  A 300 (-2.8A)
SAH  A 300 (-4.5A)
None
 0.85A 5bw4A-5dm4A:
4.4		 5bw4A-5dm4A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		4 / 4 LEU A  64
ILE A  63
GLY A  88
ILE A  77
 None
 0.87A 5dzk3-5dm4A:
undetectable
5dzkm-5dm4A:
undetectable		 5dzk3-5dm4A:
1.42
5dzkm-5dm4A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		4 / 4 ASP A  65
GLY A  69
ASP A  90
ASP A 112
 SAH  A 300 ( 4.4A)
SAH  A 300 ( 3.7A)
SAH  A 300 (-2.8A)
SAH  A 300 (-2.9A)
 0.70A 5e72A-5dm4A:
11.1		 5e72A-5dm4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		4 / 8 ASP A  65
ILE A 104
ILE A  63
PHE A 108
 SAH  A 300 ( 4.4A)
None
None
None
 0.86A 5hw8H-5dm4A:
undetectable		 5hw8H-5dm4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 SER A 153
GLU A 152
LEU A 149
ILE A 122
VAL A  61
 None
 1.40A 5vlmB-5dm4A:
undetectable		 5vlmB-5dm4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 ILE A 128
ALA A 252
LEU A 189
PHE A 132
ILE A 139
 None
 1.25A 5z6fA-5dm4A:
undetectable		 5z6fA-5dm4A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		4 / 6 PHE A 220
GLY A 218
THR A  47
TYR A 156
 None
 1.29A 6ag0A-5dm4A:
undetectable		 6ag0A-5dm4A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 GLY A  67
GLY A  69
ALA A  95
ASP A 112
ILE A 113
 SAH  A 300 (-3.6A)
SAH  A 300 ( 3.7A)
SAH  A 300 ( 4.5A)
SAH  A 300 (-2.9A)
SAH  A 300 (-4.5A)
 1.19A 6b3aA-5dm4A:
11.6		 6b3aA-5dm4A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 GLY A  67
GLY A  69
ALA A  95
ASP A 112
ILE A 113
 SAH  A 300 (-3.6A)
SAH  A 300 ( 3.7A)
SAH  A 300 ( 4.5A)
SAH  A 300 (-2.9A)
SAH  A 300 (-4.5A)
 1.16A 6b3bA-5dm4A:
11.1		 6b3bA-5dm4A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 12 ASP A  65
GLY A  67
GLY A  69
GLN A  72
ASP A 112
 SAH  A 300 ( 4.4A)
SAH  A 300 (-3.6A)
SAH  A 300 ( 3.7A)
None
SAH  A 300 (-2.9A)
 0.80A 6nj9K-5dm4A:
9.3		 6nj9K-5dm4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5dm4 METHYLTRANSFERASE
DOMAIN FAMILY
(Bacillus
pumilus) 		5 / 10 ASP A  65
GLY A  67
GLY A  69
GLN A  72
PHE A 135
 SAH  A 300 ( 4.4A)
SAH  A 300 (-3.6A)
SAH  A 300 ( 3.7A)
None
SAH  A 300 ( 4.6A)
 1.04A 6nqaK-5dm4A:
8.8		 6nqaK-5dm4A:
21.45