SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dm6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 5dm6 50S RIBOSOMAL
PROTEIN L18
(Deinococcus
radiodurans) 		3 / 3 ASP L  90
ARG L  28
ILE L  43
 None
U  Y  10 ( 2.8A)
U  Y  10 ( 4.8A)
 0.86A 1a4gB-5dm6L:
undetectable		 1a4gB-5dm6L:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5dm6 50S RIBOSOMAL
PROTEIN L21
(Deinococcus
radiodurans) 		4 / 4 ILE O   5
LEU O  25
VAL O  22
ILE O  20
 None
 0.93A 1fm6D-5dm6O:
undetectable		 1fm6D-5dm6O:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 5dm6 50S RIBOSOMAL
PROTEIN L17
(Deinococcus
radiodurans) 		5 / 12 ARG K  33
GLY K  32
LEU K 115
VAL K  48
ALA K  27
 None
None
None
None
G  X1278 ( 3.4A)
 1.23A 1gseA-5dm6K:
undetectable		 1gseA-5dm6K:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 5dm6 50S RIBOSOMAL
PROTEIN L1
(Deinococcus
radiodurans) 		5 / 10 ALA 0  82
VAL 0 110
GLY 0 147
PRO 0 113
THR 0 112
 None
 0.94A 1k6cA-5dm60:
undetectable		 1k6cA-5dm60:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5dm6 50S RIBOSOMAL
PROTEIN L1
(Deinococcus
radiodurans) 		4 / 6 LEU 0 192
LEU 0  60
GLY 0 155
ILE 0 157
 None
 0.92A 1mt1G-5dm60:
undetectable
1mt1J-5dm60:
undetectable		 1mt1G-5dm60:
16.84
1mt1J-5dm60:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 5dm6 50S RIBOSOMAL
PROTEIN L18
(Deinococcus
radiodurans) 		4 / 6 SER L  56
ILE L  38
ALA L  40
ALA L  78
 None
 0.84A 1w0gA-5dm6L:
undetectable		 1w0gA-5dm6L:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5dm6 50S RIBOSOMAL
PROTEIN L16
(Deinococcus
radiodurans) 		3 / 3 LEU J 121
HIS J 124
LYS J 125
 C  X2467 ( 4.8A)
C  X2467 ( 3.5A)
C  X2467 ( 3.0A)
 0.88A 1y7iA-5dm6J:
undetectable		 1y7iA-5dm6J:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5dm6 50S RIBOSOMAL
PROTEIN L1
(Deinococcus
radiodurans) 		5 / 11 ILE 0  18
ALA 0  21
ALA 0  22
ASN 0 180
LEU 0 181
 None
 0.87A 2aclE-5dm60:
undetectable		 2aclE-5dm60:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5dm6 50S RIBOSOMAL
PROTEIN L1
(Deinococcus
radiodurans) 		5 / 12 ILE 0  18
ALA 0  21
ALA 0  22
ASN 0 180
LEU 0 181
 None
 0.97A 2aclG-5dm60:
undetectable		 2aclG-5dm60:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5dm6 50S RIBOSOMAL
PROTEIN L6
(Deinococcus
radiodurans) 		4 / 6 LEU E  87
ARG E  95
MET E 105
LEU E 103
 None
 1.04A 2dysA-5dm6E:
undetectable
2dysJ-5dm6E:
undetectable		 2dysA-5dm6E:
14.81
2dysJ-5dm6E:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 5dm6 50S RIBOSOMAL
PROTEIN L6
(Deinococcus
radiodurans) 		4 / 5 GLN E  49
ALA E  10
ILE E   9
ARG E  69
 None
 1.29A 2z0aA-5dm6E:
undetectable		 2z0aA-5dm6E:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5dm6 50S RIBOSOMAL
PROTEIN L6
(Deinococcus
radiodurans) 		4 / 6 LEU E  87
ARG E  95
MET E 105
LEU E 103
 None
 1.06A 2zxwA-5dm6E:
undetectable
2zxwJ-5dm6E:
undetectable		 2zxwA-5dm6E:
14.81
2zxwJ-5dm6E:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5dm6 50S RIBOSOMAL
PROTEIN L6
(Deinococcus
radiodurans) 		4 / 6 LEU E  87
ARG E  95
MET E 105
LEU E 103
 None
 1.07A 3abmA-5dm6E:
undetectable
3abmJ-5dm6E:
undetectable		 3abmA-5dm6E:
14.81
3abmJ-5dm6E:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5dm6 50S RIBOSOMAL
PROTEIN L6
(Deinococcus
radiodurans) 		4 / 6 LEU E  87
ARG E  95
MET E 105
LEU E 103
 None
 1.06A 3asnA-5dm6E:
undetectable
3asnJ-5dm6E:
undetectable		 3asnA-5dm6E:
14.81
3asnJ-5dm6E:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5dm6 50S RIBOSOMAL
PROTEIN L6
(Deinococcus
radiodurans) 		4 / 6 LEU E  87
ARG E  95
MET E 105
LEU E 103
 None
 1.07A 3asoA-5dm6E:
undetectable
3asoJ-5dm6E:
undetectable		 3asoA-5dm6E:
14.81
3asoJ-5dm6E:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 5dm6 50S RIBOSOMAL
PROTEIN L1
(Deinococcus
radiodurans) 		4 / 5 VAL 0 166
VAL 0 167
THR 0 211
THR 0 164
 C  X2178 ( 4.3A)
None
A  X2176 ( 3.8A)
C  X2179 ( 3.3A)
 1.25A 3bjwG-5dm60:
undetectable		 3bjwG-5dm60:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 5dm6 50S RIBOSOMAL
PROTEIN L1
(Deinococcus
radiodurans) 		4 / 5 VAL 0 166
VAL 0 167
THR 0 211
THR 0 164
 C  X2178 ( 4.3A)
None
A  X2176 ( 3.8A)
C  X2179 ( 3.3A)
 1.25A 3bjwD-5dm60:
undetectable		 3bjwD-5dm60:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5dm6 50S RIBOSOMAL
PROTEIN L18
(Deinococcus
radiodurans) 		4 / 7 HIS L  37
VAL L  71
ALA L  68
ARG L  33
 C  Y  30 ( 3.1A)
None
None
None
 1.05A 3kp6B-5dm6L:
undetectable		 3kp6B-5dm6L:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5dm6 50S RIBOSOMAL
PROTEIN L22
(Deinococcus
radiodurans) 		4 / 5 VAL P  71
LEU P  72
ILE P  45
ALA P  95
 None
 0.97A 3n8yB-5dm6P:
undetectable		 3n8yB-5dm6P:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 5dm6 50S RIBOSOMAL
PROTEIN L13
(Deinococcus
radiodurans) 		5 / 9 VAL G  82
VAL G  81
VAL G 131
ILE G 127
ALA G 152
 None
 1.23A 4fwdA-5dm6G:
undetectable		 4fwdA-5dm6G:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5dm6 50S RIBOSOMAL
PROTEIN L16
(Deinococcus
radiodurans) 		5 / 12 PRO J  71
GLN J  47
ILE J  48
VAL J  97
VAL J  98
 None
G  X2485 ( 4.0A)
None
None
None
 1.25A 4yfbC-5dm6J:
undetectable		 4yfbC-5dm6J:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5dm6 50S RIBOSOMAL
PROTEIN L16
(Deinococcus
radiodurans) 		5 / 12 PRO J  71
GLN J  47
ILE J  48
VAL J  97
VAL J  98
 None
G  X2485 ( 4.0A)
None
None
None
 1.26A 4yfbF-5dm6J:
undetectable		 4yfbF-5dm6J:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5dm6 50S RIBOSOMAL
PROTEIN L16
(Deinococcus
radiodurans) 		5 / 12 PRO J  71
GLN J  47
ILE J  48
VAL J  97
VAL J  98
 None
G  X2485 ( 4.0A)
None
None
None
 1.25A 4yfbI-5dm6J:
undetectable		 4yfbI-5dm6J:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5dm6 50S RIBOSOMAL
PROTEIN L16
(Deinococcus
radiodurans) 		5 / 12 PRO J  71
GLN J  47
ILE J  48
VAL J  97
VAL J  98
 None
G  X2485 ( 4.0A)
None
None
None
 1.24A 4yfbL-5dm6J:
0.5		 4yfbL-5dm6J:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5dm6 50S RIBOSOMAL
PROTEIN L19
(Deinococcus
radiodurans) 		4 / 6 GLU M  95
GLY M  97
GLY M  30
ASP M  31
 None
 0.79A 5a06D-5dm6M:
undetectable		 5a06D-5dm6M:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5dm6 50S RIBOSOMAL
PROTEIN L16
(Deinococcus
radiodurans) 		4 / 8 VAL J 137
GLU J 106
GLY J  25
GLY J 101
 None
None
U  X 907 ( 2.9A)
None
 0.83A 5e26C-5dm6J:
undetectable
5e26D-5dm6J:
undetectable		 5e26C-5dm6J:
15.57
5e26D-5dm6J:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5dm6 50S RIBOSOMAL
PROTEIN L6
(Deinococcus
radiodurans) 		4 / 6 ASN E  38
LEU E  64
ARG E  69
GLY E  66
 None
None
None
A  X2748 ( 3.4A)
 0.93A 5o4yA-5dm6E:
undetectable		 5o4yA-5dm6E:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5dm6 50S RIBOSOMAL
PROTEIN L19
(Deinococcus
radiodurans) 		4 / 6 PRO M  29
VAL M  33
VAL M  91
ILE M  57
 None
 0.95A 5pbeA-5dm6M:
undetectable		 5pbeA-5dm6M:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 5dm6 50S RIBOSOMAL
PROTEIN L18
(Deinococcus
radiodurans) 		5 / 12 SER L  56
ILE L  38
ALA L  40
ALA L  78
GLY L 110
 None
 1.07A 5veuB-5dm6L:
undetectable		 5veuB-5dm6L:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 5dm6 50S RIBOSOMAL
PROTEIN L13
(Deinococcus
radiodurans) 		5 / 12 MET G 134
ALA G 130
GLU G 124
LEU G 148
VAL G  88
 G  X1137 ( 4.0A)
G  X1138 ( 3.2A)
None
None
None
 1.45A 5vlmC-5dm6G:
undetectable		 5vlmC-5dm6G:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 5dm6 50S RIBOSOMAL
PROTEIN L13
(Deinococcus
radiodurans) 		5 / 12 MET G 134
ALA G 130
GLU G 124
LEU G 148
VAL G  88
 G  X1137 ( 4.0A)
G  X1138 ( 3.2A)
None
None
None
 1.33A 5vlmH-5dm6G:
undetectable		 5vlmH-5dm6G:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5dm6 50S RIBOSOMAL
PROTEIN L21
(Deinococcus
radiodurans) 		5 / 9 ASP O  18
ILE O   5
GLY O  97
SER O  15
GLY O  41
 None
 1.29A 6awoA-5dm6O:
undetectable		 6awoA-5dm6O:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5dm6 50S RIBOSOMAL
PROTEIN L21
(Deinococcus
radiodurans) 		5 / 9 ASP O  18
ILE O   5
GLY O  97
SER O  15
GLY O  41
 None
 1.29A 6awqA-5dm6O:
undetectable		 6awqA-5dm6O:
10.63