SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dmh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 ALA A 309
LEU A 351
THR A 363
PHE A 366
LEU A 381
None
1.08A 1bzfA-5dmhA:
undetectable
1bzfA-5dmhA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 ALA A 313
LEU A 358
LEU A 269
LEU A 299
ALA A 308
None
0.82A 1bzfA-5dmhA:
undetectable
1bzfA-5dmhA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 9 GLY A 232
ALA A 209
THR A 122
THR A 231
ILE A 236
None
1.29A 1gtfE-5dmhA:
undetectable
1gtfF-5dmhA:
undetectable
1gtfE-5dmhA:
9.45
1gtfF-5dmhA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 10 GLY A 232
ALA A 209
THR A 122
THR A 231
ILE A 236
None
1.29A 1gtnN-5dmhA:
undetectable
1gtnO-5dmhA:
undetectable
1gtnN-5dmhA:
9.45
1gtnO-5dmhA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 9 GLY A 232
ALA A 209
THR A 122
THR A 231
ILE A 236
None
1.29A 1gtnS-5dmhA:
undetectable
1gtnT-5dmhA:
undetectable
1gtnS-5dmhA:
9.45
1gtnT-5dmhA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 9 PHE A  98
TYR A  94
THR A 231
VAL A 177
VAL A 166
None
1.43A 1iwjA-5dmhA:
undetectable
1iwjA-5dmhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
4 / 7 GLY A 233
ILE A 236
ALA A 110
ILE A 106
None
0.64A 1n49A-5dmhA:
undetectable
1n49A-5dmhA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
4 / 5 ASP A 307
LEU A 299
ALA A 309
LEU A 310
None
1.11A 1nh8A-5dmhA:
1.9
1nh8A-5dmhA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 10 PHE A  98
TYR A  94
THR A 231
VAL A 177
VAL A 166
None
1.36A 1o76A-5dmhA:
undetectable
1o76A-5dmhA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
3 / 3 ASP A  99
THR A  65
GLU A 348
None
None
ADP  A 501 (-3.0A)
0.80A 1pj7A-5dmhA:
2.3
1pj7A-5dmhA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A  20
LEU A 269
VAL A 267
VAL A 377
THR A 373
None
None
None
None
ADP  A 501 (-3.8A)
1.14A 1q23B-5dmhA:
undetectable
1q23B-5dmhA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 THR A  20
LEU A 269
VAL A 267
VAL A 377
THR A 373
None
None
None
None
ADP  A 501 (-3.8A)
1.02A 1q23F-5dmhA:
undetectable
1q23F-5dmhA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 9 PHE A  98
TYR A  94
THR A 231
VAL A 177
VAL A 166
None
1.41A 1t86B-5dmhA:
undetectable
1t86B-5dmhA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 GLY A 232
ALA A 209
THR A 122
THR A 231
ILE A 236
None
1.31A 1utdM-5dmhA:
undetectable
1utdN-5dmhA:
undetectable
1utdM-5dmhA:
9.45
1utdN-5dmhA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 10 GLY A 232
ALA A 209
THR A 122
THR A 231
ILE A 236
None
1.30A 1utdQ-5dmhA:
undetectable
1utdR-5dmhA:
undetectable
1utdQ-5dmhA:
9.45
1utdR-5dmhA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 MET A 206
LEU A 169
ILE A 135
SER A  96
PHE A  98
None
1.44A 1xomA-5dmhA:
undetectable
1xomA-5dmhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 MET A 206
LEU A 169
ILE A 135
SER A  96
PHE A  98
None
1.47A 1xomB-5dmhA:
undetectable
1xomB-5dmhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 MET A 206
LEU A 169
ILE A 135
SER A  96
PHE A  98
None
1.46A 1xoqA-5dmhA:
undetectable
1xoqA-5dmhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 LEU A 169
ILE A 135
SER A  96
PHE A  98
ILE A 106
None
1.21A 1xotA-5dmhA:
undetectable
1xotA-5dmhA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 10 PHE A  98
TYR A  94
THR A 231
VAL A 177
VAL A 166
None
1.37A 2cp4A-5dmhA:
undetectable
2cp4A-5dmhA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
4 / 4 LEU A 220
ILE A 135
ILE A 208
ALA A 207
None
0.86A 2i30A-5dmhA:
undetectable
2i30A-5dmhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 ASP A  99
GLY A 233
ILE A 236
ALA A 110
ILE A 106
None
0.73A 2nmyB-5dmhA:
undetectable
2nmyB-5dmhA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 7 PHE A  98
TYR A  94
THR A 231
VAL A 177
VAL A 166
None
1.40A 2qbnA-5dmhA:
undetectable
2qbnA-5dmhA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 10 PHE A  98
TYR A  94
THR A 231
VAL A 177
VAL A 166
None
1.38A 2qboA-5dmhA:
undetectable
2qboA-5dmhA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 LEU A 165
ASP A  99
GLY A 233
GLY A 235
LEU A 140
None
1.17A 2uvnA-5dmhA:
undetectable
2uvnA-5dmhA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
6 / 10 LEU A 358
VAL A 267
GLY A 266
GLY A 357
LEU A 310
ALA A 313
None
1.48A 2v3kA-5dmhA:
3.1
2v3kA-5dmhA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 10 THR A  97
VAL A 396
GLY A 395
GLY A 417
ARG A 133
None
1.09A 2wd9C-5dmhA:
undetectable
2wd9C-5dmhA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 ALA A 124
GLY A 178
GLY A 138
ASP A 210
ILE A 135
None
0.91A 2x1lA-5dmhA:
2.4
2x1lA-5dmhA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 ALA A 124
GLY A 178
GLY A 138
ASP A 210
ILE A 135
None
0.93A 2x1lB-5dmhA:
undetectable
2x1lB-5dmhA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 ALA A 124
GLY A 178
GLY A 138
ASP A 210
ILE A 135
None
0.95A 2x1lC-5dmhA:
undetectable
2x1lC-5dmhA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 10 GLY A 414
GLY A 371
HIS A 155
THR A 373
PRO A 156
ADP  A 501 (-3.2A)
ADP  A 501 (-3.5A)
ADP  A 501 (-3.8A)
ADP  A 501 (-3.8A)
ADP  A 501 (-4.2A)
1.37A 2y7wB-5dmhA:
1.7
2y7wB-5dmhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 10 THR A 277
GLY A 414
GLY A 271
HIS A 155
THR A 325
None
ADP  A 501 (-3.2A)
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
None
1.36A 2y7wB-5dmhA:
1.7
2y7wB-5dmhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
4 / 4 GLU A 372
ARG A  64
ASN A 105
ASP A  17
None
0.96A 2zq9A-5dmhA:
undetectable
2zq9A-5dmhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
4 / 5 VAL A 377
VAL A 378
THR A 363
THR A 373
None
None
None
ADP  A 501 (-3.8A)
1.17A 3bjwG-5dmhA:
undetectable
3bjwG-5dmhA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
4 / 5 VAL A 377
VAL A 378
THR A 363
THR A 373
None
None
None
ADP  A 501 (-3.8A)
1.19A 3bjwC-5dmhA:
undetectable
3bjwC-5dmhA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
4 / 5 VAL A 377
VAL A 378
THR A 363
THR A 373
None
None
None
ADP  A 501 (-3.8A)
1.16A 3bjwD-5dmhA:
undetectable
3bjwD-5dmhA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
4 / 8 ALA A  78
LEU A  79
TYR A  94
ILE A 236
None
0.78A 3cldB-5dmhA:
undetectable
3cldB-5dmhA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 9 PHE A  98
TYR A  94
THR A 231
VAL A 177
VAL A 166
None
1.42A 3cppA-5dmhA:
undetectable
3cppA-5dmhA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 10 ASP A  99
GLY A 233
ILE A 236
ALA A 110
ILE A 106
None
0.64A 3ekpB-5dmhA:
undetectable
3ekpB-5dmhA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 10 ASP A  99
GLY A 233
ILE A 236
ALA A 110
ILE A 106
None
0.85A 3ekpC-5dmhA:
undetectable
3ekpC-5dmhA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 9 ASP A  99
GLY A 233
ILE A 236
ALA A 110
ILE A 106
None
0.78A 3ektB-5dmhA:
undetectable
3ektB-5dmhA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 10 ILE A 106
GLY A 232
ILE A 236
ALA A 207
ILE A 208
None
1.01A 3ekwA-5dmhA:
undetectable
3ekwA-5dmhA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
6 / 9 LEU A 179
ILE A 106
GLY A 232
ILE A 236
ALA A 207
ILE A 208
None
1.35A 3el0B-5dmhA:
undetectable
3el0B-5dmhA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 THR A 277
ALA A 369
GLY A 370
ASP A  99
CYH A  95
None
None
ADP  A 501 (-3.3A)
None
None
1.30A 3mg0H-5dmhA:
undetectable
3mg0I-5dmhA:
undetectable
3mg0H-5dmhA:
20.58
3mg0I-5dmhA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
3 / 3 VAL A 347
VAL A 331
SER A 326
ADP  A 501 (-3.8A)
ADP  A 501 ( 3.9A)
ADP  A 501 (-2.7A)
0.70A 3n8xB-5dmhA:
undetectable
3n8xB-5dmhA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
4 / 6 GLN A  74
GLN A  38
ILE A  40
SER A  63
None
1.20A 3peoG-5dmhA:
undetectable
3peoG-5dmhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 LEU A 169
ASP A  99
GLY A 233
ILE A 236
ILE A 106
None
0.97A 4dqhA-5dmhA:
undetectable
4dqhA-5dmhA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 ALA A  56
SER A 234
PHE A 218
VAL A  91
THR A  36
None
1.43A 4eilA-5dmhA:
undetectable
4eilA-5dmhA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 ALA A  56
SER A 234
PHE A 218
VAL A  91
THR A  36
None
1.41A 4eilC-5dmhA:
undetectable
4eilC-5dmhA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 9 PHE A  98
TYR A  94
THR A 231
VAL A 177
VAL A 166
None
1.48A 4ek1B-5dmhA:
undetectable
4ek1B-5dmhA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
4 / 8 THR A  23
THR A 373
VAL A 368
ASP A  18
None
ADP  A 501 (-3.8A)
None
None
0.84A 4l4aA-5dmhA:
undetectable
4l4aA-5dmhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 GLN A 335
ALA A 270
GLY A 271
ALA A 273
THR A 277
ADP  A 501 ( 4.9A)
None
ADP  A 501 (-3.6A)
ADP  A 501 ( 4.5A)
None
1.25A 4qvpH-5dmhA:
undetectable
4qvpI-5dmhA:
undetectable
4qvpH-5dmhA:
22.04
4qvpI-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.19A 4qvpH-5dmhA:
undetectable
4qvpI-5dmhA:
undetectable
4qvpH-5dmhA:
22.04
4qvpI-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 GLN A 335
ALA A 270
GLY A 271
ALA A 273
THR A 277
ADP  A 501 ( 4.9A)
None
ADP  A 501 (-3.6A)
ADP  A 501 ( 4.5A)
None
1.25A 4qvpV-5dmhA:
undetectable
4qvpW-5dmhA:
undetectable
4qvpV-5dmhA:
22.04
4qvpW-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.19A 4qvpV-5dmhA:
undetectable
4qvpW-5dmhA:
undetectable
4qvpV-5dmhA:
22.04
4qvpW-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.17A 4qvvV-5dmhA:
undetectable
4qvvV-5dmhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.16A 4qvyV-5dmhA:
undetectable
4qvyW-5dmhA:
undetectable
4qvyV-5dmhA:
22.04
4qvyW-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 ALA A 369
GLY A 370
THR A  20
ASP A  99
CYH A  95
None
ADP  A 501 (-3.3A)
None
None
None
1.27A 4qw0H-5dmhA:
undetectable
4qw0I-5dmhA:
undetectable
4qw0H-5dmhA:
22.04
4qw0I-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 GLN A 335
ALA A 270
GLY A 271
ALA A 273
THR A 277
ADP  A 501 ( 4.9A)
None
ADP  A 501 (-3.6A)
ADP  A 501 ( 4.5A)
None
1.28A 4qw0H-5dmhA:
undetectable
4qw0I-5dmhA:
undetectable
4qw0H-5dmhA:
22.04
4qw0I-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.17A 4qw0H-5dmhA:
undetectable
4qw0I-5dmhA:
undetectable
4qw0H-5dmhA:
22.04
4qw0I-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.18A 4qw0V-5dmhA:
undetectable
4qw0W-5dmhA:
undetectable
4qw0V-5dmhA:
22.04
4qw0W-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 ALA A 369
GLY A 370
THR A  20
ASP A  99
CYH A  95
None
ADP  A 501 (-3.3A)
None
None
None
1.28A 4qw1H-5dmhA:
undetectable
4qw1I-5dmhA:
undetectable
4qw1H-5dmhA:
22.04
4qw1I-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 GLN A 335
ALA A 270
GLY A 271
ALA A 273
THR A 277
ADP  A 501 ( 4.9A)
None
ADP  A 501 (-3.6A)
ADP  A 501 ( 4.5A)
None
1.26A 4qw1H-5dmhA:
undetectable
4qw1I-5dmhA:
undetectable
4qw1H-5dmhA:
22.04
4qw1I-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.19A 4qw1H-5dmhA:
undetectable
4qw1I-5dmhA:
undetectable
4qw1H-5dmhA:
22.04
4qw1I-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 ALA A 369
GLY A 370
THR A  20
ASP A  99
CYH A  95
None
ADP  A 501 (-3.3A)
None
None
None
1.28A 4qw1V-5dmhA:
undetectable
4qw1W-5dmhA:
undetectable
4qw1V-5dmhA:
22.04
4qw1W-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 GLN A 335
ALA A 270
GLY A 271
ALA A 273
THR A 277
ADP  A 501 ( 4.9A)
None
ADP  A 501 (-3.6A)
ADP  A 501 ( 4.5A)
None
1.27A 4qw1V-5dmhA:
undetectable
4qw1W-5dmhA:
undetectable
4qw1V-5dmhA:
22.04
4qw1W-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.19A 4qw1V-5dmhA:
undetectable
4qw1W-5dmhA:
undetectable
4qw1V-5dmhA:
22.04
4qw1W-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 GLY A  13
PRO A  10
ALA A  54
LEU A  82
ALA A  22
None
1.19A 5bw4B-5dmhA:
undetectable
5bw4B-5dmhA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.21A 5bxnH-5dmhA:
undetectable
5bxnI-5dmhA:
undetectable
5bxnH-5dmhA:
22.27
5bxnI-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 11 THR A 277
ALA A 369
GLY A 370
ASP A  99
CYH A  95
None
None
ADP  A 501 (-3.3A)
None
None
1.34A 5bxnV-5dmhA:
undetectable
5bxnW-5dmhA:
undetectable
5bxnV-5dmhA:
22.27
5bxnW-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 GLN A 335
ALA A 270
GLY A 271
ALA A 273
THR A 277
ADP  A 501 ( 4.9A)
None
ADP  A 501 (-3.6A)
ADP  A 501 ( 4.5A)
None
1.25A 5cz7V-5dmhA:
undetectable
5cz7W-5dmhA:
undetectable
5cz7V-5dmhA:
22.04
5cz7W-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.17A 5cz7V-5dmhA:
undetectable
5cz7W-5dmhA:
undetectable
5cz7V-5dmhA:
22.04
5cz7W-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
4 / 5 SER A 413
SER A 100
GLN A 172
ASP A  18
ADP  A 501 ( 4.4A)
None
None
None
1.47A 5fhrB-5dmhA:
undetectable
5fhrB-5dmhA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 9 ALA A  16
ASP A  17
ASP A  18
GLY A 233
ILE A 236
None
1.15A 5kr2A-5dmhA:
undetectable
5kr2A-5dmhA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 9 ALA A  16
ASP A  17
ASP A  18
GLY A 233
ILE A 236
None
1.14A 5kr2C-5dmhA:
undetectable
5kr2C-5dmhA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 9 LEU A 179
ILE A 106
GLY A 232
ILE A 236
ILE A 208
None
1.15A 5kr2D-5dmhA:
undetectable
5kr2D-5dmhA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.17A 5l5fH-5dmhA:
undetectable
5l5fI-5dmhA:
undetectable
5l5fH-5dmhA:
22.04
5l5fI-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.17A 5l5fV-5dmhA:
undetectable
5l5fW-5dmhA:
undetectable
5l5fV-5dmhA:
22.04
5l5fW-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 ALA A 369
GLY A 370
THR A  20
ASP A  99
CYH A  95
None
ADP  A 501 (-3.3A)
None
None
None
1.26A 5l5zH-5dmhA:
undetectable
5l5zI-5dmhA:
undetectable
5l5zH-5dmhA:
22.04
5l5zI-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 GLN A 335
ALA A 270
GLY A 271
ALA A 273
THR A 277
ADP  A 501 ( 4.9A)
None
ADP  A 501 (-3.6A)
ADP  A 501 ( 4.5A)
None
1.25A 5l5zH-5dmhA:
undetectable
5l5zI-5dmhA:
undetectable
5l5zH-5dmhA:
22.04
5l5zI-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
ALA A 369
GLY A 370
ASP A  99
CYH A  95
None
None
ADP  A 501 (-3.3A)
None
None
1.29A 5l5zH-5dmhA:
undetectable
5l5zI-5dmhA:
undetectable
5l5zH-5dmhA:
22.04
5l5zI-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.19A 5l5zH-5dmhA:
undetectable
5l5zI-5dmhA:
undetectable
5l5zH-5dmhA:
22.04
5l5zI-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 ALA A 369
GLY A 370
THR A  20
ASP A  99
CYH A  95
None
ADP  A 501 (-3.3A)
None
None
None
1.27A 5l5zV-5dmhA:
undetectable
5l5zW-5dmhA:
undetectable
5l5zV-5dmhA:
22.04
5l5zW-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 GLN A 335
ALA A 270
GLY A 271
ALA A 273
THR A 277
ADP  A 501 ( 4.9A)
None
ADP  A 501 (-3.6A)
ADP  A 501 ( 4.5A)
None
1.23A 5l5zV-5dmhA:
undetectable
5l5zW-5dmhA:
undetectable
5l5zV-5dmhA:
22.04
5l5zW-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
ALA A 369
GLY A 370
ASP A  99
CYH A  95
None
None
ADP  A 501 (-3.3A)
None
None
1.30A 5l5zV-5dmhA:
undetectable
5l5zW-5dmhA:
undetectable
5l5zV-5dmhA:
22.04
5l5zW-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.19A 5l5zV-5dmhA:
undetectable
5l5zW-5dmhA:
undetectable
5l5zV-5dmhA:
22.04
5l5zW-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 ALA A 369
GLY A 370
THR A  20
ASP A  99
CYH A  95
None
ADP  A 501 (-3.3A)
None
None
None
1.27A 5l66H-5dmhA:
undetectable
5l66I-5dmhA:
undetectable
5l66H-5dmhA:
22.04
5l66I-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.19A 5l66H-5dmhA:
undetectable
5l66I-5dmhA:
undetectable
5l66H-5dmhA:
22.04
5l66I-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 ALA A 369
GLY A 370
THR A  20
ASP A  99
CYH A  95
None
ADP  A 501 (-3.3A)
None
None
None
1.28A 5l66V-5dmhA:
undetectable
5l66W-5dmhA:
undetectable
5l66V-5dmhA:
22.04
5l66W-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.19A 5l66V-5dmhA:
undetectable
5l66W-5dmhA:
undetectable
5l66V-5dmhA:
22.04
5l66W-5dmhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 10 THR A 277
LYS A 412
ALA A 270
GLY A 271
THR A 373
None
None
None
ADP  A 501 (-3.6A)
ADP  A 501 (-3.8A)
1.14A 5lf3V-5dmhA:
undetectable
5lf3W-5dmhA:
undetectable
5lf3V-5dmhA:
20.61
5lf3W-5dmhA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
3 / 3 THR A 161
MET A 152
HIS A 154
None
0.93A 5uunA-5dmhA:
1.7
5uunA-5dmhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 PHE A  98
SER A 173
GLN A 172
ARG A  64
ASP A  17
None
1.46A 6bxnA-5dmhA:
4.4
6bxnA-5dmhA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
4 / 7 ILE A  40
GLN A  38
VAL A  59
ALA A  78
None
0.74A 6cduC-5dmhA:
undetectable
6cduD-5dmhA:
undetectable
6cduC-5dmhA:
21.74
6cduD-5dmhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator)
5 / 12 PRO A 394
GLY A  21
GLY A 235
GLY A 233
VAL A  91
None
0.89A 6nj9K-5dmhA:
undetectable
6nj9K-5dmhA:
21.57