SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dmn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 170
ILE A  67
LEU A 216
VAL A 212
VAL A 251
 None
 1.15A 1hrkA-5dmnA:
undetectable		 1hrkA-5dmnA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 245
LEU A 242
LEU A 239
ALA A 238
LEU A 203
 None
 1.10A 1ya3C-5dmnA:
undetectable		 1ya3C-5dmnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ALA A 162
ALA A 119
THR A  68
VAL A  96
TYR A 253
 None
 1.00A 2fr3A-5dmnA:
undetectable		 2fr3A-5dmnA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ALA A 278
PRO A 254
GLY A  21
ASP A 302
LEU A 306
 None
 1.30A 2nv4A-5dmnA:
undetectable		 2nv4A-5dmnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ALA A 278
PRO A 254
GLY A  21
ASP A 302
LEU A 306
 None
 1.34A 2nv4B-5dmnA:
undetectable		 2nv4B-5dmnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 170
ILE A  67
LEU A 216
VAL A 212
VAL A 251
 None
 1.19A 2po7A-5dmnA:
2.4		 2po7A-5dmnA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		4 / 7 THR A 235
TRP A 284
ASN A 255
TYR A 280
 None
 1.34A 4a3uA-5dmnA:
12.9		 4a3uA-5dmnA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		4 / 7 THR A 235
TRP A 284
ASN A 255
TYR A 280
 None
 1.29A 4a3uB-5dmnA:
12.5		 4a3uB-5dmnA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 9 THR A 246
LEU A 239
LEU A 250
GLY A 226
VAL A 213
 None
 1.29A 4c9kB-5dmnA:
undetectable		 4c9kB-5dmnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 10 THR A 246
LEU A 239
LEU A 250
GLY A 226
VAL A 213
 None
 1.29A 4c9nB-5dmnA:
undetectable		 4c9nB-5dmnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 9 THR A 246
LEU A 239
LEU A 250
GLY A 226
VAL A 213
 None
 1.33A 4c9pA-5dmnA:
undetectable		 4c9pA-5dmnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 10 THR A 246
LEU A 239
LEU A 250
GLY A 226
VAL A 213
 None
 1.35A 4c9pB-5dmnA:
undetectable		 4c9pB-5dmnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		4 / 5 SER A  88
LYS A  89
LEU A  83
ASP A  84
 None
None
None
SO4  A 401 ( 4.2A)
 1.43A 4ifxA-5dmnA:
undetectable		 4ifxA-5dmnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		4 / 5 SER A  88
LYS A  89
LEU A  83
ASP A  84
 None
None
None
SO4  A 401 ( 4.2A)
 1.43A 4ig1A-5dmnA:
undetectable		 4ig1A-5dmnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 245
LEU A 242
LEU A 239
ALA A 238
LEU A 203
 None
 1.09A 4ltwA-5dmnA:
undetectable		 4ltwA-5dmnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A  17
ALA A 119
LEU A 116
ILE A  67
 None
 0.76A 4ubsA-5dmnA:
undetectable		 4ubsA-5dmnA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		4 / 5 SER A  88
LYS A  89
LEU A  83
ASP A  84
 None
None
None
SO4  A 401 ( 4.2A)
 1.44A 4xdtA-5dmnA:
undetectable		 4xdtA-5dmnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 203
LEU A 248
PHE A 195
PHE A 193
ALA A 180
 None
 0.96A 5ieoA-5dmnA:
undetectable		 5ieoA-5dmnA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 203
LEU A 248
PHE A 195
PHE A 193
ALA A 180
 None
 0.97A 5iepA-5dmnA:
undetectable		 5iepA-5dmnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  19
ILE A  67
LEU A  17
LEU A  10
LEU A 117
 None
 1.13A 5nfjB-5dmnA:
undetectable		 5nfjB-5dmnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  19
ILE A  67
LEU A  17
LEU A  10
LEU A 117
 None
 1.11A 5nfjC-5dmnA:
undetectable		 5nfjC-5dmnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ALA A 119
GLY A 120
SER A 121
LEU A  17
ASP A  20
 None
 1.02A 5w7pA-5dmnA:
undetectable		 5w7pA-5dmnA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 157
VAL A  96
GLU A 168
THR A 298
GLY A 294
 None
 1.29A 5xipC-5dmnA:
undetectable		 5xipC-5dmnA:
20.24