SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dmq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
5 / 9 GLY A 305
LEU A 304
TYR A 344
TRP A 336
LEU A 324
None
1.44A 1y7iA-5dmqA:
undetectable
1y7iA-5dmqA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
5 / 10 LEU A 304
PHE A 303
TYR A 344
TRP A 336
LEU A 324
None
1.48A 1y7iB-5dmqA:
undetectable
1y7iB-5dmqA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
3 / 3 PRO A 130
THR A 128
PRO A 127
None
0.81A 2d55C-5dmqA:
undetectable
2d55C-5dmqA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
3 / 3 VAL A 546
TRP A 521
VAL A 540
None
0.88A 2izqA-5dmqA:
undetectable
2izqB-5dmqA:
undetectable
2izqA-5dmqA:
9.09
2izqB-5dmqA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
3 / 3 ARG A 585
GLN A 639
PRO A 636
None
0.95A 2qhfA-5dmqA:
undetectable
2qhfA-5dmqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
5 / 10 ALA A 573
LEU A 509
LEU A 624
LEU A 570
LEU A 630
None
1.14A 2riwA-5dmqA:
undetectable
2riwB-5dmqA:
undetectable
2riwA-5dmqA:
20.49
2riwB-5dmqA:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
5 / 12 LEU A 151
LEU A 219
LEU A 207
HIS A 204
PHE A 199
None
1.28A 3glqB-5dmqA:
undetectable
3glqB-5dmqA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
4 / 7 ILE A 617
LEU A 624
THR A 582
THR A 505
None
1.08A 3nxuA-5dmqA:
undetectable
3nxuA-5dmqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
5 / 12 ILE A 564
LEU A 563
ALA A 558
SER A 527
LEU A 552
None
1.04A 4m11B-5dmqA:
undetectable
4m11B-5dmqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
4 / 4 CYH A 310
LEU A 280
LEU A 351
ALA A 354
None
1.14A 5hpuA-5dmqA:
undetectable
5hpuB-5dmqA:
undetectable
5hpuA-5dmqA:
3.12
5hpuB-5dmqA:
3.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
3 / 3 THR A 523
ALA A 569
LYS A 571
None
0.71A 6fgcA-5dmqA:
undetectable
6fgcA-5dmqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
3 / 3 THR A 523
ALA A 569
LYS A 571
None
0.72A 6fgdA-5dmqA:
undetectable
6fgdA-5dmqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine
leukemia
virus)
4 / 5 ASP A 653
ASP A 524
ARG A 657
GLN A 639
None
1.25A 6g31F-5dmqA:
undetectable
6g31F-5dmqA:
8.68