SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dmu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		3 / 3 VAL A 194
VAL A 196
TRP A 272
 None
 0.74A 1av2C-5dmuA:
undetectable
1av2D-5dmuA:
undetectable		 1av2C-5dmuA:
4.63
1av2D-5dmuA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		3 / 3 VAL A 194
VAL A 196
TRP A 272
 None
 0.77A 1w5uC-5dmuA:
undetectable
1w5uD-5dmuA:
undetectable		 1w5uC-5dmuA:
4.63
1w5uD-5dmuA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		3 / 3 VAL A 196
TRP A 272
VAL A 194
 None
 0.84A 2izqA-5dmuA:
undetectable
2izqB-5dmuA:
undetectable		 2izqA-5dmuA:
4.63
2izqB-5dmuA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		3 / 3 VAL A 194
VAL A 196
TRP A 272
 None
 0.80A 3l8lA-5dmuA:
undetectable
3l8lB-5dmuA:
undetectable		 3l8lA-5dmuA:
4.63
3l8lB-5dmuA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		3 / 3 VAL A 194
VAL A 196
TRP A 272
 None
 0.79A 3l8lC-5dmuA:
undetectable
3l8lD-5dmuA:
undetectable		 3l8lC-5dmuA:
4.63
3l8lD-5dmuA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		5 / 12 MET A  72
VAL A 115
ILE A 132
VAL A 258
TYR A  55
 None
 1.48A 3p6gA-5dmuA:
undetectable		 3p6gA-5dmuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		4 / 5 ILE A  59
VAL A 124
LEU A  25
ASP A  54
 None
 1.22A 3wzdA-5dmuA:
undetectable		 3wzdA-5dmuA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		5 / 12 GLY A  80
GLY A  82
ILE A 132
ALA A 260
ALA A 130
 None
None
None
EDO  A 401 ( 4.4A)
None
 1.02A 4kicA-5dmuA:
undetectable		 4kicA-5dmuA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		5 / 12 GLY A  80
GLY A  82
ILE A 132
ALA A 260
ALA A 130
 None
None
None
EDO  A 401 ( 4.4A)
None
 1.02A 4kicB-5dmuA:
undetectable		 4kicB-5dmuA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		4 / 5 ARG A 259
GLY A 188
ALA A 267
PRO A 265
 EDO  A 401 (-3.9A)
None
None
None
 0.98A 4u9uB-5dmuA:
undetectable		 4u9uB-5dmuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		3 / 3 ASP A 298
ARG A 140
ARG A 149
 None
 0.87A 4x5iA-5dmuA:
undetectable		 4x5iA-5dmuA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		4 / 8 HIS A 145
TYR A 248
PHE A 137
PRO A  71
 None
 1.15A 5v4vA-5dmuA:
undetectable		 5v4vA-5dmuA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		4 / 8 HIS A 145
TYR A 248
PHE A 137
PRO A  71
 None
 1.17A 5v4vB-5dmuA:
undetectable		 5v4vB-5dmuA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5dmu NHEJ POLYMERASE
(Methanocella
paludicola) 		3 / 3 GLY A  46
THR A  48
GLU A  51
 None
EDO  A 402 (-2.9A)
None
 0.58A 6b58A-5dmuA:
undetectable		 6b58A-5dmuA:
20.07