SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ
(Salmonella
enterica) 		5 / 11 PRO A 162
LEU A 178
VAL A 203
GLY A 188
LEU A 156
 IOD  A 401 ( 4.5A)
None
None
None
None
 1.38A 1fkpA-5dn5A:
undetectable		 1fkpA-5dn5A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ
(Salmonella
enterica) 		5 / 11 PRO A 162
LEU A 178
VAL A 203
GLY A 188
LEU A 156
 IOD  A 401 ( 4.5A)
None
None
None
None
 1.42A 1lwcA-5dn5A:
undetectable		 1lwcA-5dn5A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ
(Salmonella
enterica) 		4 / 7 PHE A 204
LEU A 178
ALA A 181
PHE A 155
 None
 0.93A 2vcvG-5dn5A:
undetectable		 2vcvG-5dn5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ
(Salmonella
enterica) 		4 / 7 PHE A 204
LEU A 178
ALA A 181
PHE A 155
 None
 0.88A 2vcvL-5dn5A:
undetectable		 2vcvL-5dn5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ
(Salmonella
enterica) 		5 / 6 TYR A 286
ALA A 287
LEU A 290
ALA A 268
THR A 267
 None
 1.30A 3b6hB-5dn5A:
undetectable		 3b6hB-5dn5A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ
(Salmonella
enterica) 		4 / 6 LEU A 165
GLU A 168
ARG A 164
HIS A 174
 None
 1.31A 3ltwA-5dn5A:
undetectable		 3ltwA-5dn5A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ
(Salmonella
enterica) 		5 / 12 ARG A 190
GLY A 188
LEU A 156
SER A 160
ALA A 181
 None
 1.24A 3sxjA-5dn5A:
undetectable		 3sxjA-5dn5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ
(Salmonella
enterica) 		5 / 12 ARG A 190
GLY A 188
LEU A 156
SER A 160
ALA A 181
 None
 1.23A 3sxjB-5dn5A:
undetectable		 3sxjB-5dn5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ
(Salmonella
enterica) 		3 / 3 SER A 241
TYR A 239
TYR A 201
 IOD  A 401 ( 4.9A)
None
None
 0.76A 5lakA-5dn5A:
undetectable
5lakI-5dn5A:
undetectable		 5lakA-5dn5A:
18.15
5lakI-5dn5A:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ
(Salmonella
enterica) 		3 / 3 SER A 241
TYR A 239
TYR A 201
 IOD  A 401 ( 4.9A)
None
None
 0.80A 5lakC-5dn5A:
undetectable
5lakJ-5dn5A:
undetectable		 5lakC-5dn5A:
18.15
5lakJ-5dn5A:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ
(Salmonella
enterica) 		3 / 3 LEU A 246
ILE A 177
TYR A 280
 None
 0.69A 5uunB-5dn5A:
undetectable		 5uunB-5dn5A:
22.45