SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dn6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 5dn6 ATP SYNTHASE GAMMA
CHAIN
ZETA INHIBITOR
PROTEIN
(Paracoccus
denitrificans) 		4 / 7 GLN G 242
GLU G 241
MET G  24
PHE Z  14
 None
 0.95A 1linA-5dn6G:
undetectable		 1linA-5dn6G:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 12 ILE A 168
GLY A 169
ILE A 327
THR A 330
ALA A 365
 None
 1.06A 1nv8B-5dn6A:
2.3		 1nv8B-5dn6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 11 LEU A  12
ILE A  16
ASP A  45
GLY A  43
TYR A  42
 None
 1.21A 1zz1A-5dn6A:
undetectable		 1zz1A-5dn6A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 10 THR A 231
GLY A 255
THR A 252
ALA A 253
VAL A 108
 None
 1.45A 2coiA-5dn6A:
undetectable
2coiB-5dn6A:
undetectable		 2coiA-5dn6A:
22.81
2coiB-5dn6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 11 THR A 231
GLY A 255
THR A 252
ALA A 253
VAL A 108
 None
 1.41A 2cojA-5dn6A:
undetectable
2cojB-5dn6A:
undetectable		 2cojA-5dn6A:
22.81
2cojB-5dn6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 9 VAL A 108
THR A 231
GLY A 255
THR A 252
ALA A 253
 None
 1.35A 2cojA-5dn6A:
undetectable
2cojB-5dn6A:
undetectable		 2cojA-5dn6A:
22.81
2cojB-5dn6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 9 VAL A 142
GLY A 162
LEU A 313
SER A 321
ASP A 264
 None
 1.24A 2j2pB-5dn6A:
undetectable
2j2pC-5dn6A:
undetectable		 2j2pB-5dn6A:
17.64
2j2pC-5dn6A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		4 / 4 GLU A 394
ARG A 421
ASN A 420
ASP A 455
 None
 1.36A 2zq9A-5dn6A:
undetectable		 2zq9A-5dn6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		4 / 6 THR A 148
GLN A 186
LEU A 325
LEU A 266
 None
 1.18A 3bgdA-5dn6A:
2.3		 3bgdA-5dn6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 12 GLY A 112
ASN A 113
ILE A 203
GLY A 255
PRO A 114
 None
 1.12A 3eeyD-5dn6A:
2.6		 3eeyD-5dn6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		3 / 3 PRO A 436
LEU A 437
GLN A 431
 None
 0.65A 3hznG-5dn6A:
undetectable
3hznH-5dn6A:
undetectable		 3hznG-5dn6A:
17.74
3hznH-5dn6A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		3 / 3 LYS A 312
ARG A 161
LYS A 385
 None
 1.50A 3okxA-5dn6A:
3.0		 3okxA-5dn6A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 5dn6 ATP SYNTHASE GAMMA
CHAIN
(Paracoccus
denitrificans) 		5 / 11 VAL G  81
VAL G 230
ALA G 155
LEU G 174
LEU G 118
 None
 1.00A 3sm2B-5dn6G:
undetectable		 3sm2B-5dn6G:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 12 ASP A 154
LEU A 353
GLY A 149
ASN A 185
VAL A 153
 None
 1.02A 3vasB-5dn6A:
undetectable		 3vasB-5dn6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 12 ASP A 154
LEU A 353
GLY A 149
ASN A 185
VAL A 153
 None
 0.99A 4dc3A-5dn6A:
2.4		 4dc3A-5dn6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 12 VAL A 159
SER A 371
GLY A 349
ASP A 154
THR A 148
 None
 1.38A 4mm4A-5dn6A:
undetectable		 4mm4A-5dn6A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 10 VAL A 159
SER A 371
GLY A 349
ASP A 154
THR A 148
 None
 1.39A 4mm7A-5dn6A:
undetectable		 4mm7A-5dn6A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 12 ALA A 276
PHE A 300
THR A 341
THR A 347
LEU A 307
 None
 1.15A 4z7fC-5dn6A:
undetectable		 4z7fC-5dn6A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5dn6 ATP SYNTHASE GAMMA
CHAIN
(Paracoccus
denitrificans) 		5 / 12 LYS G 212
ASP G 220
ASN G 215
ALA G  58
VAL G  52
 None
 1.29A 5kbwB-5dn6G:
undetectable		 5kbwB-5dn6G:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5dn6 ATP SYNTHASE GAMMA
CHAIN
(Paracoccus
denitrificans) 		4 / 7 PHE G 164
ASP G 170
GLY G  71
GLY G  73
 None
 1.02A 5n9xA-5dn6G:
undetectable		 5n9xA-5dn6G:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5dn6 ATP SYNTHASE GAMMA
CHAIN
(Paracoccus
denitrificans) 		5 / 10 GLN G 127
LEU G  80
GLU G 131
GLY G 133
ALA G 101
 None
 1.09A 5o96E-5dn6G:
undetectable
5o96F-5dn6G:
undetectable		 5o96E-5dn6G:
23.08
5o96F-5dn6G:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		4 / 8 MET A 243
LEU A 246
MET A 254
ARG A 309
 None
 1.28A 6cbzA-5dn6A:
undetectable		 6cbzA-5dn6A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 12 LEU A 272
ASP A 270
ALA A 251
LEU A 306
LEU A 322
 None
MG  A 601 ( 3.9A)
None
None
None
 1.14A 6ew0F-5dn6A:
2.5		 6ew0F-5dn6A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		3 / 3 MET A 282
GLN A 281
ARG A 280
 None
 1.02A 6fn9A-5dn6A:
3.0		 6fn9A-5dn6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		3 / 3 MET A 282
GLN A 281
ARG A 280
 None
 1.00A 6fnaB-5dn6A:
3.5		 6fnaB-5dn6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 9 ASP A 130
MET A  52
TYR A 245
GLY A  37
VAL A  73
 None
 1.44A 6giqA-5dn6A:
3.4
6giqE-5dn6A:
undetectable
6giqI-5dn6A:
undetectable		 6giqA-5dn6A:
26.03
6giqE-5dn6A:
18.36
6giqI-5dn6A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 11 ASP A 130
MET A  52
TYR A 245
GLY A  37
VAL A  73
 None
 1.33A 6hu9A-5dn6A:
3.0
6hu9E-5dn6A:
undetectable
6hu9I-5dn6A:
undetectable		 6hu9A-5dn6A:
26.47
6hu9E-5dn6A:
18.24
6hu9I-5dn6A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5dn6 ATP SYNTHASE SUBUNIT
ALPHA
(Paracoccus
denitrificans) 		5 / 10 ASP A 130
MET A  52
TYR A 245
GLY A  37
VAL A  73
 None
 1.34A 6hu9L-5dn6A:
undetectable
6hu9P-5dn6A:
undetectable
6hu9T-5dn6A:
undetectable		 6hu9L-5dn6A:
26.47
6hu9P-5dn6A:
18.24
6hu9T-5dn6A:
8.51