SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dn8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		4 / 7 VAL A 334
LEU A 191
SER A 189
ALA A 237
 None
None
GDP  A 501 (-4.5A)
None
 0.86A 1j8uA-5dn8A:
undetectable		 1j8uA-5dn8A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		4 / 7 HIS A 389
ASN A 420
LEU A 352
GLN A 350
 None
 0.93A 1qzrB-5dn8A:
undetectable		 1qzrB-5dn8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		5 / 12 LEU A 116
LEU A 107
THR A  57
ILE A 144
LEU A 155
 None
 0.95A 1tw4B-5dn8A:
undetectable		 1tw4B-5dn8A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		5 / 12 GLY A  58
GLY A  59
ILE A 249
VAL A  76
ALA A  79
 None
 0.79A 1v2xA-5dn8A:
2.1		 1v2xA-5dn8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5dn8 GTPASE DER
(Coxiella
burnetii) 		4 / 8 ARG A 236
SER A 189
ASP A 229
ALA A 237
 GDP  A 501 (-2.9A)
GDP  A 501 (-4.5A)
None
None
 1.19A 2rk8A-5dn8A:
2.3		 2rk8A-5dn8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		5 / 9 PHE A  19
ILE A 181
ALA A 254
GLY A  43
LEU A  53
 None
 1.22A 2v0mB-5dn8A:
undetectable		 2v0mB-5dn8A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		4 / 5 ASP A  56
ILE A 103
ILE A   7
GLY A  58
 GDP  A 502 ( 4.7A)
None
None
None
 0.80A 3bufA-5dn8A:
undetectable		 3bufA-5dn8A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		5 / 12 LEU A 191
GLY A 187
ILE A 326
ALA A 267
ASP A 297
 None
GDP  A 501 (-3.4A)
None
None
GDP  A 501 (-2.9A)
 1.08A 3gwwA-5dn8A:
undetectable		 3gwwA-5dn8A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		5 / 9 ARG A 388
LEU A 385
ALA A 383
LEU A 411
ILE A 393
 None
 1.43A 3wsjA-5dn8A:
undetectable		 3wsjA-5dn8A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		4 / 7 TYR A 324
VAL A 260
ILE A 178
LEU A 191
 None
 1.00A 4l1wA-5dn8A:
undetectable		 4l1wA-5dn8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5dn8 GTPASE DER
(Coxiella
burnetii) 		4 / 5 LYS A 429
ILE A 428
HIS A 427
VAL A 426
 None
 0.94A 5jmnA-5dn8A:
undetectable		 5jmnA-5dn8A:
18.23