SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dne'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 6 SER A 325
THR A 324
LEU A 321
ASP A 322
 None
 1.18A 1mxdA-5dneA:
undetectable		 1mxdA-5dneA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 8 SER A 325
THR A 324
LEU A 321
ASP A 322
 None
 1.21A 1mxgA-5dneA:
undetectable		 1mxgA-5dneA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		5 / 9 LEU A  42
ARG A 154
LEU A  38
LEU A  35
ALA A 153
 None
 1.35A 2bxeA-5dneA:
undetectable		 2bxeA-5dneA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.23A 2eimJ-5dneA:
undetectable		 2eimJ-5dneA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.26A 2eimW-5dneA:
undetectable		 2eimW-5dneA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		5 / 9 ALA A 120
ALA A 123
SER A 127
PHE A 128
ALA A 327
 None
 1.14A 2vh3A-5dneA:
undetectable		 2vh3A-5dneA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.14A 3ag1J-5dneA:
undetectable		 3ag1J-5dneA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.30A 3ag2J-5dneA:
undetectable		 3ag2J-5dneA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.14A 3ag4J-5dneA:
undetectable		 3ag4J-5dneA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		3 / 3 GLU A 171
VAL A 172
CYH A 173
 None
 1.05A 3fbxA-5dneA:
undetectable		 3fbxA-5dneA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		3 / 3 PRO A  81
LEU A  82
GLN A  80
 None
 0.61A 3hznG-5dneA:
undetectable
3hznH-5dneA:
undetectable		 3hznG-5dneA:
17.35
3hznH-5dneA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 7 GLU A 348
GLN A 347
VAL A 318
ALA A 351
 None
 1.07A 3kp6B-5dneA:
undetectable		 3kp6B-5dneA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 8 LEU A  13
TYR A  15
LEU A  39
TYR A  74
 None
 0.93A 3v81C-5dneA:
undetectable		 3v81C-5dneA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		5 / 12 PRO A 145
ILE A 146
GLY A  18
ASP A 117
LEU A 174
 None
None
ASN  A 601 (-3.5A)
ASN  A 601 (-3.0A)
None
 1.20A 3v8vA-5dneA:
undetectable		 3v8vA-5dneA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 8 PHE A 110
ALA A  97
LEU A 228
LEU A 133
 None
 0.69A 4ejgB-5dneA:
undetectable		 4ejgB-5dneA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 7 PHE A 110
ALA A  97
LEU A 228
LEU A 133
 None
 0.67A 4ejgC-5dneA:
undetectable		 4ejgC-5dneA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		3 / 3 PRO A 339
ASN A 233
HIS A 231
 None
 0.86A 4ma3H-5dneA:
undetectable
4ma3L-5dneA:
undetectable		 4ma3H-5dneA:
16.78
4ma3L-5dneA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 8 LEU A  13
TYR A  15
LEU A  39
TYR A  74
 None
 0.89A 4pwdC-5dneA:
undetectable		 4pwdC-5dneA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 4 ALA A  53
PRO A  64
LEU A  39
HIS A  46
 None
 1.47A 5eskA-5dneA:
undetectable		 5eskA-5dneA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		5 / 12 ILE A 317
GLY A 314
LEU A 256
LEU A 291
MET A 293
 None
 1.20A 5nfjB-5dneA:
undetectable		 5nfjB-5dneA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		5 / 12 ILE A 317
GLY A 314
LEU A 256
LEU A 291
MET A 293
 None
 1.19A 5nfjC-5dneA:
undetectable		 5nfjC-5dneA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		3 / 3 LEU A  20
ILE A 113
TYR A  74
 None
 0.63A 5uunB-5dneA:
undetectable		 5uunB-5dneA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		5 / 12 GLY A 269
GLY A 271
GLU A 266
VAL A 252
ILE A 247
 None
 0.97A 5vimA-5dneA:
undetectable		 5vimA-5dneA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.34A 5w97J-5dneA:
undetectable		 5w97J-5dneA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.16A 5wauJ-5dneA:
undetectable		 5wauJ-5dneA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.14A 5x19J-5dneA:
undetectable		 5x19J-5dneA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.15A 5x1bJ-5dneA:
undetectable		 5x1bJ-5dneA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.12A 5x1bW-5dneA:
undetectable		 5x1bW-5dneA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 6 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.10A 5x1fA-5dneA:
undetectable
5x1fJ-5dneA:
undetectable		 5x1fA-5dneA:
21.08
5x1fJ-5dneA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.18A 5x1fW-5dneA:
undetectable		 5x1fW-5dneA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		5 / 9 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.28A 6czmA-5dneA:
undetectable
6czmB-5dneA:
undetectable		 6czmA-5dneA:
21.90
6czmB-5dneA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		5 / 9 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.31A 6czmB-5dneA:
undetectable
6czmC-5dneA:
undetectable		 6czmB-5dneA:
21.90
6czmC-5dneA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		5 / 9 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.34A 6czmD-5dneA:
undetectable
6czmE-5dneA:
undetectable		 6czmD-5dneA:
21.90
6czmE-5dneA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		5 / 10 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.27A 6czmE-5dneA:
undetectable
6czmF-5dneA:
undetectable		 6czmE-5dneA:
21.90
6czmF-5dneA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		5 / 11 LEU A 139
HIS A 114
GLY A 115
PHE A 197
ALA A 196
 None
None
ASN  A 601 (-3.2A)
None
None
 1.12A 6ieyA-5dneA:
undetectable
6ieyB-5dneA:
2.5		 6ieyA-5dneA:
19.46
6ieyB-5dneA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dne L-ASPARAGINASE
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.10A 6nknJ-5dneA:
undetectable		 6nknJ-5dneA:
6.63