SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dnw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 5dnw SHKAI2IB
(Striga
hermonthica) 		5 / 12 PHE A 174
PHE A 157
MET A 218
ALA A 219
HIS A  94
 None
 1.24A 1a4lA-5dnwA:
undetectable		 1a4lA-5dnwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 5dnw SHKAI2IB
(Striga
hermonthica) 		5 / 12 PHE A 174
PHE A 157
MET A 218
ALA A 219
HIS A  94
 None
 1.21A 1a4lB-5dnwA:
undetectable		 1a4lB-5dnwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5dnw SHKAI2IB
(Striga
hermonthica) 		3 / 3 ALA A  98
VAL A  92
TRP A  33
 None
 0.74A 1av2C-5dnwA:
undetectable
1av2D-5dnwA:
undetectable		 1av2C-5dnwA:
5.21
1av2D-5dnwA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 6 PRO A 253
GLN A 249
LYS A  34
VAL A  37
 None
 1.43A 1l2iB-5dnwA:
undetectable		 1l2iB-5dnwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 5dnw SHKAI2IB
(Striga
hermonthica) 		3 / 3 ALA A  98
VAL A  92
TRP A  33
 None
 0.77A 1nt6A-5dnwA:
undetectable		 1nt6A-5dnwA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 5dnw SHKAI2IB
(Striga
hermonthica) 		3 / 3 ALA A  98
VAL A  92
TRP A  33
 None
 0.76A 1nt6B-5dnwA:
undetectable		 1nt6B-5dnwA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 8 ILE A  80
LEU A  77
PHE A  91
GLY A  93
 None
 1.02A 1os6A-5dnwA:
undetectable		 1os6A-5dnwA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5dnw SHKAI2IB
(Striga
hermonthica) 		3 / 3 ALA A  98
VAL A  92
TRP A  33
 None
 0.76A 1w5uC-5dnwA:
undetectable
1w5uD-5dnwA:
undetectable		 1w5uC-5dnwA:
5.21
1w5uD-5dnwA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5dnw SHKAI2IB
(Striga
hermonthica) 		5 / 12 LEU A 142
HIS A 246
ASP A 217
GLY A 245
PHE A 194
 None
 1.21A 1zz1B-5dnwA:
undetectable
1zz1C-5dnwA:
undetectable		 1zz1B-5dnwA:
22.98
1zz1C-5dnwA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5dnw SHKAI2IB
(Striga
hermonthica) 		3 / 3 TRP A  33
ALA A  98
VAL A  92
 None
 0.74A 2izqA-5dnwA:
undetectable
2izqB-5dnwA:
undetectable		 2izqA-5dnwA:
5.21
2izqB-5dnwA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dnw SHKAI2IB
(Striga
hermonthica) 		5 / 12 SER A  97
TYR A  67
GLY A  72
ALA A  74
LEU A  78
 None
 1.03A 3hs6A-5dnwA:
undetectable		 3hs6A-5dnwA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5dnw SHKAI2IB
(Striga
hermonthica) 		3 / 3 ALA A  98
VAL A  92
TRP A  33
 None
 0.76A 3l8lA-5dnwA:
undetectable
3l8lB-5dnwA:
undetectable		 3l8lA-5dnwA:
5.21
3l8lB-5dnwA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5dnw SHKAI2IB
(Striga
hermonthica) 		3 / 3 ALA A  98
VAL A  92
TRP A  33
 None
 0.77A 3l8lC-5dnwA:
undetectable
3l8lD-5dnwA:
undetectable		 3l8lC-5dnwA:
5.21
3l8lD-5dnwA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 5dnw SHKAI2IB
(Striga
hermonthica) 		5 / 12 GLU A 173
GLY A  27
VAL A  32
PHE A  26
PHE A 157
 None
 1.32A 3qowA-5dnwA:
2.1		 3qowA-5dnwA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 8 ILE A  80
LEU A  77
PHE A  91
GLY A  93
 None
 1.02A 3selX-5dnwA:
undetectable		 3selX-5dnwA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 6 ILE A  80
LEU A  77
PHE A  91
GLY A  93
 None
 0.89A 3sj1X-5dnwA:
undetectable		 3sj1X-5dnwA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5dnw SHKAI2IB
(Striga
hermonthica) 		5 / 12 HIS A  94
GLY A  25
SER A  95
LEU A 125
GLY A 132
 None
 1.24A 4blvB-5dnwA:
undetectable		 4blvB-5dnwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 7 PHE A  91
PHE A 112
ALA A  74
LEU A  81
 None
 0.83A 4ejgA-5dnwA:
undetectable		 4ejgA-5dnwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 8 PHE A  91
PHE A 112
ALA A  74
LEU A  81
 None
 0.77A 4ejgB-5dnwA:
undetectable		 4ejgB-5dnwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 7 PHE A  91
PHE A 112
ALA A  74
LEU A  81
 None
 0.78A 4ejgC-5dnwA:
undetectable		 4ejgC-5dnwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 7 ILE A  80
LEU A  77
PHE A  91
GLY A  93
 None
 0.91A 4hbfA-5dnwA:
undetectable		 4hbfA-5dnwA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 7 ILE A  80
LEU A  77
PHE A  91
GLY A  93
 None
 0.98A 4hc3A-5dnwA:
undetectable		 4hc3A-5dnwA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 7 VAL A 224
ILE A 228
LEU A  70
LEU A 198
 FMT  A 303 ( 4.4A)
None
None
None
 1.00A 4l1wA-5dnwA:
undetectable		 4l1wA-5dnwA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 6 ARG A 123
GLY A 132
ASP A 197
PRO A 122
 None
 1.08A 4lajA-5dnwA:
undetectable
4lajB-5dnwA:
undetectable		 4lajA-5dnwA:
22.48
4lajB-5dnwA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 5dnw SHKAI2IB
(Striga
hermonthica) 		5 / 12 PHE A  91
GLY A  23
LEU A  77
TYR A  73
LEU A  70
 None
 1.05A 4pd4C-5dnwA:
undetectable		 4pd4C-5dnwA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5dnw SHKAI2IB
(Striga
hermonthica) 		5 / 12 GLY A  16
LEU A  81
PHE A 112
GLY A 101
THR A  18
 None
 1.19A 4ze1A-5dnwA:
undetectable		 4ze1A-5dnwA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DNU_A_BEZA319_0
(SHKAI2IB)		 5dnw SHKAI2IB
(Striga
hermonthica) 		5 / 5 GLN A  71
HIS A  75
ILE A 103
ILE A 107
TYR A 201
 None
 0.09A 5dnuA-5dnwA:
50.1		 5dnuA-5dnwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5dnw SHKAI2IB
(Striga
hermonthica) 		5 / 5 GLN A  71
HIS A  75
ILE A 103
ILE A 107
TYR A 201
 None
 0.18A 5dnvA-5dnwA:
46.2		 5dnvA-5dnwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5dnw SHKAI2IB
(Striga
hermonthica) 		5 / 12 GLY A  16
LEU A  81
PHE A 112
GLY A 101
THR A  18
 None
 1.19A 5eskA-5dnwA:
undetectable		 5eskA-5dnwA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 8 ILE A 193
PHE A 157
GLY A  27
LEU A 247
 None
 0.81A 5hs1A-5dnwA:
undetectable		 5hs1A-5dnwA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5dnw SHKAI2IB
(Striga
hermonthica) 		3 / 3 ARG A   8
HIS A  75
ARG A  66
 None
 1.02A 5iaoC-5dnwA:
undetectable		 5iaoC-5dnwA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5dnw SHKAI2IB
(Striga
hermonthica) 		3 / 3 ARG A   8
HIS A  75
ARG A  66
 None
 1.07A 5iaoF-5dnwA:
undetectable		 5iaoF-5dnwA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 5 ILE A 115
ILE A 228
HIS A 229
VAL A 232
 None
 0.98A 5jmnA-5dnwA:
undetectable		 5jmnA-5dnwA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dnw SHKAI2IB
(Striga
hermonthica) 		4 / 5 LEU A  81
PHE A  84
LEU A  77
PHE A  91
 None
 1.22A 5x1fC-5dnwA:
undetectable
5x1fJ-5dnwA:
undetectable		 5x1fC-5dnwA:
21.77
5x1fJ-5dnwA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 5dnw SHKAI2IB
(Striga
hermonthica) 		5 / 12 TYR A 201
ILE A 106
GLY A  72
ALA A  74
LEU A  77
 None
 1.20A 5zwrA-5dnwA:
undetectable		 5zwrA-5dnwA:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5dnw SHKAI2IB
(Striga
hermonthica) 		7 / 12 PHE A  26
PHE A 124
PHE A 134
TRP A 153
PHE A 157
PHE A 194
HIS A 246
 None
 0.87A 6ap6A-5dnwA:
38.3		 6ap6A-5dnwA:
53.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5dnw SHKAI2IB
(Striga
hermonthica) 		7 / 12 PHE A  26
PHE A 124
PHE A 134
TRP A 153
PHE A 157
PHE A 194
HIS A 246
 None
 0.88A 6ap6B-5dnwA:
38.4		 6ap6B-5dnwA:
53.31