SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dny'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A  68
LEU A  50
LEU A  11
ALA A  64
ILE A  39
 None
 1.15A 1crbA-5dnyA:
undetectable		 1crbA-5dnyA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  49
HIS A  85
HIS A  10
 MG  A 402 ( 2.7A)
None
MG  A 401 (-3.5A)
 0.44A 1oe1A-5dnyA:
undetectable		 1oe1A-5dnyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  49
HIS A  85
HIS A  10
 MG  A 402 ( 2.7A)
None
MG  A 401 (-3.5A)
 0.44A 1oe3A-5dnyA:
undetectable		 1oe3A-5dnyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 8 HIS A  10
ASP A  49
HIS A 186
TYR A 202
HIS A 188
 MG  A 401 (-3.5A)
MG  A 402 ( 2.7A)
MG  A 402 (-2.7A)
None
MG  A 401 (-3.4A)
 1.47A 1v7zA-5dnyA:
undetectable		 1v7zA-5dnyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 8 HIS A  10
ASP A  49
HIS A 186
TYR A 202
HIS A 188
 MG  A 401 (-3.5A)
MG  A 402 ( 2.7A)
MG  A 402 (-2.7A)
None
MG  A 401 (-3.4A)
 1.49A 1v7zC-5dnyA:
undetectable		 1v7zC-5dnyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 8 HIS A  10
ASP A  49
HIS A 186
TYR A 202
HIS A 188
 MG  A 401 (-3.5A)
MG  A 402 ( 2.7A)
MG  A 402 (-2.7A)
None
MG  A 401 (-3.4A)
 1.46A 1v7zD-5dnyA:
undetectable		 1v7zD-5dnyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 8 HIS A  10
ASP A  49
HIS A 186
TYR A 202
HIS A 188
 MG  A 401 (-3.5A)
MG  A 402 ( 2.7A)
MG  A 402 (-2.7A)
None
MG  A 401 (-3.4A)
 1.48A 1v7zE-5dnyA:
undetectable		 1v7zE-5dnyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 8 HIS A  10
ASP A  49
HIS A 186
TYR A 202
HIS A 188
 MG  A 401 (-3.5A)
MG  A 402 ( 2.7A)
MG  A 402 (-2.7A)
None
MG  A 401 (-3.4A)
 1.49A 1v7zF-5dnyA:
undetectable		 1v7zF-5dnyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 191
HIS A  10
HIS A 188
ASP A  49
GLY A  48
 None
MG  A 401 (-3.5A)
MG  A 401 (-3.4A)
MG  A 402 ( 2.7A)
None
 1.25A 1zz1A-5dnyA:
undetectable		 1zz1A-5dnyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A 204
ILE A 165
ALA A   7
HIS A  10
 None
None
None
MG  A 401 (-3.5A)
 0.90A 2x0pA-5dnyA:
undetectable		 2x0pA-5dnyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  49
HIS A  85
HIS A  10
 MG  A 402 ( 2.7A)
None
MG  A 401 (-3.5A)
 0.44A 2xxgA-5dnyA:
undetectable		 2xxgA-5dnyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  49
HIS A  85
HIS A  10
 MG  A 402 ( 2.7A)
None
MG  A 401 (-3.5A)
 0.46A 2xxgC-5dnyA:
undetectable		 2xxgC-5dnyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A   7
GLY A 185
HIS A 188
LEU A  45
TYR A 225
 None
None
MG  A 401 (-3.4A)
None
None
 1.38A 3bxoB-5dnyA:
undetectable		 3bxoB-5dnyA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A 213
TYR A 217
GLY A 204
ASP A 243
ASP A   8
 None
None
None
None
MG  A 401 (-2.8A)
 1.35A 3nmuA-5dnyA:
undetectable
3nmuF-5dnyA:
undetectable		 3nmuA-5dnyA:
23.06
3nmuF-5dnyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A   8
ALA A   7
SER A  47
TYR A 202
 MG  A 401 (-2.8A)
None
None
None
 1.04A 3rodA-5dnyA:
undetectable		 3rodA-5dnyA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A   0
GLU A 118
ASN A 232
 None
 0.68A 4bupB-5dnyA:
undetectable		 4bupB-5dnyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 12 ASN A  74
ILE A  76
ALA A  67
VAL A  44
VAL A  78
 None
 1.03A 4nkvA-5dnyA:
undetectable		 4nkvA-5dnyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 12 ASN A  74
ILE A  76
ALA A  67
VAL A  44
VAL A  78
 None
 1.04A 4nkvC-5dnyA:
undetectable		 4nkvC-5dnyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 12 ASN A  74
ILE A  76
ALA A  67
VAL A  44
VAL A  78
 None
 1.03A 4nkvD-5dnyA:
undetectable		 4nkvD-5dnyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 12 ASN A  74
ILE A  76
ALA A  67
VAL A  44
VAL A  78
 None
 1.03A 4nkxA-5dnyA:
undetectable		 4nkxA-5dnyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 100
VAL A  44
LEU A  71
LEU A  50
ALA A  64
 None
 1.08A 4p65B-5dnyA:
undetectable
4p65D-5dnyA:
undetectable
4p65G-5dnyA:
undetectable
4p65H-5dnyA:
undetectable		 4p65B-5dnyA:
6.67
4p65D-5dnyA:
6.67
4p65G-5dnyA:
4.47
4p65H-5dnyA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A 180
LEU A 107
MET A 156
 None
 0.75A 5ikrB-5dnyA:
undetectable		 5ikrB-5dnyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 239
ILE A 199
VAL A 227
ASN A 232
ASP A 233
 None
 1.21A 5lg3J-5dnyA:
undetectable		 5lg3J-5dnyA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  49
ASP A   8
HIS A  10
HIS A 188
 MG  A 402 ( 2.7A)
MG  A 401 (-2.8A)
MG  A 401 (-3.5A)
MG  A 401 (-3.4A)
 0.86A 5ncdA-5dnyA:
undetectable
5ncdD-5dnyA:
undetectable		 5ncdA-5dnyA:
20.25
5ncdD-5dnyA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  49
ASP A   8
HIS A  10
HIS A 188
 MG  A 402 ( 2.7A)
MG  A 401 (-2.8A)
MG  A 401 (-3.5A)
MG  A 401 (-3.4A)
 0.85A 5ncdB-5dnyA:
undetectable
5ncdC-5dnyA:
undetectable		 5ncdB-5dnyA:
20.25
5ncdC-5dnyA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A  49
ASP A   8
HIS A  10
HIS A 188
 MG  A 402 ( 2.7A)
MG  A 401 (-2.8A)
MG  A 401 (-3.5A)
MG  A 401 (-3.4A)
 0.97A 5nekB-5dnyA:
undetectable		 5nekB-5dnyA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  49
ASP A   8
HIS A  10
HIS A 188
 MG  A 402 ( 2.7A)
MG  A 401 (-2.8A)
MG  A 401 (-3.5A)
MG  A 401 (-3.4A)
 0.79A 5nelA-5dnyA:
undetectable
5nelD-5dnyA:
undetectable		 5nelA-5dnyA:
20.25
5nelD-5dnyA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  49
HIS A  10
HIS A 188
HIS A 158
 MG  A 402 ( 2.7A)
MG  A 401 (-3.5A)
MG  A 401 (-3.4A)
MG  A 402 (-4.2A)
 0.92A 5nelA-5dnyA:
undetectable
5nelD-5dnyA:
undetectable		 5nelA-5dnyA:
20.25
5nelD-5dnyA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  49
HIS A  10
HIS A 188
HIS A 158
 MG  A 402 ( 2.7A)
MG  A 401 (-3.5A)
MG  A 401 (-3.4A)
MG  A 402 (-4.2A)
 0.92A 5nelB-5dnyA:
undetectable
5nelC-5dnyA:
undetectable		 5nelB-5dnyA:
20.25
5nelC-5dnyA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 10 HIS A 158
HIS A 186
ASP A  49
TYR A  13
HIS A  10
 MG  A 402 (-4.2A)
MG  A 402 (-2.7A)
MG  A 402 ( 2.7A)
None
MG  A 401 (-3.5A)
 1.15A 5nzwA-5dnyA:
undetectable		 5nzwA-5dnyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A   0
GLU A 118
ASN A 232
 None
 0.72A 5wbvA-5dnyA:
undetectable		 5wbvA-5dnyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A   0
GLU A 118
ASN A 232
 None
 0.73A 5wbvB-5dnyA:
undetectable		 5wbvB-5dnyA:
21.01