SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5do7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		5 / 12 ILE A  84
VAL A 246
VAL A  72
ILE A  40
ILE A 342
 None
 1.03A 1epbB-5do7A:
undetectable		 1epbB-5do7A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		3 / 3 ALA B 573
VAL B 593
TRP B 589
 None
 1.02A 1gmkC-5do7B:
undetectable
1gmkD-5do7B:
undetectable		 1gmkC-5do7B:
2.71
1gmkD-5do7B:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 5 TYR A 628
PRO A 632
LEU A 634
THR A 430
 None
 1.27A 1i2wA-5do7A:
undetectable		 1i2wA-5do7A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		6 / 12 ASP A 182
GLU A 146
ARG A 381
ILE A 185
ILE A 193
THR A 147
 None
 1.50A 1kijA-5do7A:
undetectable		 1kijA-5do7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		3 / 3 ALA B 248
HIS B 249
VAL B 252
 None
 0.50A 1lqtB-5do7B:
undetectable		 1lqtB-5do7B:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 GLU B 503
ASP B 466
ILE B 468
TYR B 472
GLN B 667
 None
 1.32A 1oltA-5do7B:
undetectable		 1oltA-5do7B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 9 LEU B 101
LEU B 266
ILE B 235
LEU B 114
ILE B 103
 None
 1.24A 2f7aA-5do7B:
undetectable		 2f7aA-5do7B:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		5 / 12 THR A 137
LEU A 142
HIS A 470
ALA A 447
TYR A 458
 None
 1.34A 2g72A-5do7A:
undetectable		 2g72A-5do7A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		4 / 5 ALA B 495
ALA B 551
ALA B 550
VAL B 467
 None
 0.81A 2nyrB-5do7B:
undetectable		 2nyrB-5do7B:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		5 / 10 VAL A 232
VAL A 233
ASP A 261
ILE A  81
VAL A 245
 None
 1.46A 2qboA-5do7A:
undetectable		 2qboA-5do7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 ILE B 223
ILE B 118
ILE B 233
VAL B 144
HIS B 150
 None
 1.11A 2qo5A-5do7B:
undetectable		 2qo5A-5do7B:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 PHE A 403
PHE B 595
PHE B 654
LEU B 650
SER B 569
 None
 1.34A 3apvB-5do7A:
undetectable		 3apvB-5do7A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		3 / 3 HIS B 504
GLU B 503
HIS B 420
 None
 0.76A 3ba0A-5do7B:
undetectable		 3ba0A-5do7B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 LEU B 635
ALA B 573
VAL B 538
GLY B 602
GLU B 601
 None
 1.11A 3c6gB-5do7B:
undetectable		 3c6gB-5do7B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		4 / 8 LEU B 580
ALA B 588
SER B 591
ARG B 597
 None
 1.01A 3kp6A-5do7B:
2.0		 3kp6A-5do7B:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		5 / 12 ASP A 182
GLU A 146
ARG A 381
ILE A 193
THR A 147
 None
 1.50A 3lpsA-5do7A:
undetectable		 3lpsA-5do7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens;
Homo
sapiens) 		4 / 6 SER A 532
PHE B 556
HIS B 557
ASN A 528
 None
 1.27A 3lskB-5do7A:
undetectable		 3lskB-5do7A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VXI_A_ASCA502_0
(DYP)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 5 ALA A 478
ASN A 437
ARG A 389
HIS A 510
 None
 1.46A 3vxiA-5do7A:
undetectable		 3vxiA-5do7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		4 / 4 PRO B 239
LEU B 269
ILE B 276
ARG B 273
 None
 1.42A 3w1wA-5do7B:
undetectable		 3w1wA-5do7B:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 5 ARG A 199
THR A 221
GLN A 134
GLU A 218
 None
 1.28A 4eahA-5do7A:
undetectable
4eahE-5do7A:
undetectable
4eahG-5do7A:
undetectable		 4eahA-5do7A:
21.44
4eahE-5do7A:
21.44
4eahG-5do7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF401_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 4 ARG A 199
THR A 221
GLN A 134
GLU A 218
 None
 1.30A 4eahB-5do7A:
0.3
4eahC-5do7A:
0.7
4eahF-5do7A:
0.7		 4eahB-5do7A:
21.44
4eahC-5do7A:
21.44
4eahF-5do7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		4 / 7 TYR B 567
TYR B 571
LEU B 596
TYR B 511
 None
 1.12A 4f8yC-5do7B:
undetectable
4f8yD-5do7B:
undetectable		 4f8yC-5do7B:
13.77
4f8yD-5do7B:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		4 / 8 TYR B 511
VAL B 535
HIS B 531
LEU B 451
 None
 1.10A 4jtrA-5do7B:
undetectable		 4jtrA-5do7B:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		5 / 10 ILE A 156
ALA A 155
THR A 151
MET A 214
LEU A 207
 None
 1.41A 4kq8A-5do7A:
undetectable		 4kq8A-5do7A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		3 / 3 TRP B 361
GLN B 137
THR B 365
 None
 0.88A 4m2xA-5do7B:
undetectable		 4m2xA-5do7B:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 TYR A 424
TYR B 567
PHE B 453
VAL A 542
GLY A 428
 None
 0.95A 4mm6A-5do7A:
undetectable		 4mm6A-5do7A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER B 214
ASP A 308
ASP A 303
 None
 0.75A 4mwzA-5do7B:
undetectable		 4mwzA-5do7B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 5 ASN A 578
LEU A 575
SER A 503
ASN A 393
 None
 1.22A 4n09C-5do7A:
undetectable		 4n09C-5do7A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 LEU B 258
VAL B 265
ALA B 102
LEU B 243
VAL B 151
 None
 1.23A 4nc3A-5do7B:
undetectable		 4nc3A-5do7B:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		5 / 12 LEU A 518
ALA A 438
ALA A 468
GLY A 513
GLY A 434
 None
 1.02A 4rn6B-5do7A:
undetectable		 4rn6B-5do7A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 9 LEU B 534
ILE B 646
SER B 651
LEU B 650
VAL B 538
 None
 1.20A 4x3mB-5do7B:
undetectable		 4x3mB-5do7B:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 GLY B 512
TYR B 516
ILE B 431
GLY B 456
ILE B 459
 None
 0.79A 5d4uC-5do7B:
undetectable		 5d4uC-5do7B:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 GLY B 512
TYR B 516
ILE B 431
GLY B 456
ILE B 459
 None
 0.76A 5d4uD-5do7B:
undetectable		 5d4uD-5do7B:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_B_GLYB404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 4 GLN A 206
ALA A 205
GLN A 209
THR A 151
 None
 1.33A 5hhjB-5do7A:
undetectable		 5hhjB-5do7A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		4 / 6 VAL B 221
LEU B 157
CYH B 200
LEU B 213
 None
 1.20A 5hrqB-5do7B:
undetectable
5hrqI-5do7B:
undetectable
5hrqJ-5do7B:
undetectable		 5hrqB-5do7B:
4.21
5hrqI-5do7B:
3.56
5hrqJ-5do7B:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 LEU A 575
PHE A 502
LEU A 423
ILE B 578
THR A 430
 None
 1.13A 5ienB-5do7A:
undetectable		 5ienB-5do7A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 5 LEU A 441
PHE A 442
LEU A 379
PHE A 474
 None
 1.19A 5iy5P-5do7A:
3.2
5iy5W-5do7A:
undetectable		 5iy5P-5do7A:
16.67
5iy5W-5do7A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		5 / 12 PHE A 515
GLY A 513
TYR A 628
LEU A 627
LEU A 472
 None
 1.37A 5ji0D-5do7A:
undetectable		 5ji0D-5do7A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 LEU B 157
ILE B 192
VAL B 225
LEU B 228
VAL B 191
 None
 1.05A 5mugA-5do7B:
undetectable		 5mugA-5do7B:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 7 LEU A 422
PHE A 426
SER A 572
ILE A 539
 None
 1.05A 5n5dA-5do7A:
undetectable		 5n5dA-5do7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 ILE B  88
LEU B  91
SER B 106
GLY B 110
GLY B 105
 None
 1.08A 5nnaA-5do7B:
undetectable		 5nnaA-5do7B:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 ILE B  88
LEU B  91
SER B 106
GLY B 110
GLY B 105
 None
 1.12A 5nnaC-5do7B:
undetectable		 5nnaC-5do7B:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 ILE B  88
LEU B  91
SER B 106
GLY B 110
GLY B 105
 None
 1.04A 5nnaD-5do7B:
undetectable		 5nnaD-5do7B:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 8 VAL A 246
PHE A 129
LEU A 215
VAL A 113
 None
 0.77A 5nujA-5do7A:
undetectable		 5nujA-5do7A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		4 / 6 PHE B 453
LEU B 452
ARG B 597
GLY B 602
 None
 1.13A 5o4yA-5do7B:
undetectable		 5o4yA-5do7B:
2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 5 LEU A 441
PHE A 442
LEU A 379
PHE A 474
 None
 1.16A 5x1fC-5do7A:
3.0
5x1fJ-5do7A:
undetectable		 5x1fC-5do7A:
16.82
5x1fJ-5do7A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 5 VAL A 534
PRO A 431
GLY A 434
TYR A 432
 None
 1.13A 5x80A-5do7A:
0.2
5x80B-5do7A:
0.0		 5x80A-5do7A:
13.24
5x80B-5do7A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 5 PRO A 431
GLY A 434
TYR A 432
VAL A 534
 None
 1.07A 5x80C-5do7A:
0.1
5x80D-5do7A:
undetectable		 5x80C-5do7A:
13.24
5x80D-5do7A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens) 		4 / 5 LEU A 441
PHE A 442
LEU A 379
PHE A 474
 None
 1.23A 5xdxP-5do7A:
3.3
5xdxW-5do7A:
undetectable		 5xdxP-5do7A:
16.67
5xdxW-5do7A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 10 GLY A 500
ILE A 574
ALA A 505
LEU A 506
PHE B 576
 None
 1.15A 5zjiA-5do7A:
undetectable
5zjiJ-5do7A:
undetectable		 5zjiA-5do7A:
8.72
5zjiJ-5do7A:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens) 		5 / 12 TYR B 479
LEU B 486
GLY B 485
SER B 222
VAL B 151
 None
 1.30A 6bxlB-5do7B:
undetectable		 6bxlB-5do7B:
19.51