SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5doi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 5doi TELOMERASE
ASSOCIATED PROTEIN
P45
(Tetrahymena
thermophila) 		5 / 11 ILE E  51
ASP E  54
LEU E  10
GLY E  57
TYR E 116
 None
 1.31A 1axwB-5doiE:
undetectable		 1axwB-5doiE:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 5doi TELOMERASE
ASSOCIATED PROTEIN
P45
(Tetrahymena
thermophila) 		5 / 9 ILE E  51
ASP E  54
LEU E  10
GLY E  57
TYR E 116
 None
 1.37A 1i00A-5doiE:
undetectable		 1i00A-5doiE:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5doi TELOMERASE
ASSOCIATED PROTEIN
P45
(Tetrahymena
thermophila) 		5 / 9 ILE E  51
ASP E  54
LEU E  10
GLY E  57
TYR E 116
 None
 1.42A 1i00B-5doiE:
undetectable		 1i00B-5doiE:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 5doi TELOMERASE-ASSOCIATE
D PROTEIN 19
TELOMERASE
ASSOCIATED PROTEIN
P45
(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		5 / 11 PHE E  76
ARG A  38
LEU E  27
GLU E 112
HIS E 107
 None
 1.39A 1mjqA-5doiE:
undetectable
1mjqB-5doiE:
undetectable		 1mjqA-5doiE:
17.56
1mjqB-5doiE:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 5doi TELOMERASE-ASSOCIATE
D PROTEIN 19
TELOMERASE
ASSOCIATED PROTEIN
P45
(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		5 / 10 ARG A  38
LEU E  27
GLU E 112
HIS E 107
PHE E  76
 None
 1.39A 1mjqC-5doiA:
undetectable
1mjqD-5doiA:
undetectable		 1mjqC-5doiA:
22.97
1mjqD-5doiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 5doi TELOMERASE-ASSOCIATE
D PROTEIN 19
TELOMERASE
ASSOCIATED PROTEIN
P45
(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		5 / 10 PHE E  76
ARG A  38
LEU E  27
GLU E 112
HIS E 107
 None
 1.41A 1mjqG-5doiE:
undetectable
1mjqH-5doiE:
undetectable		 1mjqG-5doiE:
17.56
1mjqH-5doiE:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 5doi TELOMERASE-ASSOCIATE
D PROTEIN 19
(Tetrahymena
thermophila) 		4 / 6 LEU A  56
HIS A 134
ASN A 133
ILE A 136
 None
 0.78A 1xf1B-5doiA:
undetectable		 1xf1B-5doiA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5doi TELOMERASE
ASSOCIATED PROTEIN
P45
(Tetrahymena
thermophila) 		4 / 6 LEU E  63
PHE E  24
ILE E  52
ALA E  50
 None
 0.99A 2j5mA-5doiE:
undetectable		 2j5mA-5doiE:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 5doi TELOMERASE-ASSOCIATE
D PROTEIN 19
(Tetrahymena
thermophila) 		3 / 3 TYR A 123
GLY A  41
PHE A  43
 None
 0.68A 2m2pB-5doiA:
undetectable		 2m2pB-5doiA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5doi TELOMERASE
ASSOCIATED PROTEIN
P45
(Tetrahymena
thermophila) 		5 / 10 ILE E  52
ALA E  59
PHE E  24
LEU E  10
ILE E 105
 None
 1.05A 3falC-5doiE:
undetectable		 3falC-5doiE:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5doi TELOMERASE
ASSOCIATED PROTEIN
P45
(Tetrahymena
thermophila) 		5 / 11 ALA E  59
LEU E  61
GLY E  81
ILE E  73
LEU E  10
 None
 1.05A 3zosA-5doiE:
undetectable
3zosB-5doiE:
undetectable		 3zosA-5doiE:
18.03
3zosB-5doiE:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5doi TELOMERASE
ASSOCIATED PROTEIN
P45
(Tetrahymena
thermophila) 		5 / 10 ILE E  51
ASP E  54
LEU E  10
GLY E  57
TYR E 116
 None
 1.36A 4eb4D-5doiE:
undetectable		 4eb4D-5doiE:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 5doi TELOMERASE-ASSOCIATE
D PROTEIN 19
(Tetrahymena
thermophila) 		4 / 8 ASP A  16
VAL A  37
PHE A 104
LEU A 137
 None
 1.02A 4f8hB-5doiA:
undetectable
4f8hC-5doiA:
undetectable		 4f8hB-5doiA:
18.33
4f8hC-5doiA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 5doi TELOMERASE-ASSOCIATE
D PROTEIN 19
(Tetrahymena
thermophila) 		3 / 3 ARG A 128
HIS A 142
SER A  36
 None
 1.03A 4mjwA-5doiA:
undetectable
4mjwB-5doiA:
undetectable		 4mjwA-5doiA:
13.67
4mjwB-5doiA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5doi TELOMERASE
ASSOCIATED PROTEIN
P45
(Tetrahymena
thermophila) 		5 / 12 ILE E  52
ALA E  59
PHE E  24
LEU E  10
ILE E 105
 None
 1.07A 4nqaH-5doiE:
undetectable		 4nqaH-5doiE:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5doi TELOMERASE
ASSOCIATED PROTEIN
P45
(Tetrahymena
thermophila) 		5 / 11 LEU E  29
ASP E  54
LEU E  10
GLY E  57
TYR E 116
 None
 1.36A 5fctA-5doiE:
undetectable		 5fctA-5doiE:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 5doi TELOMERASE-ASSOCIATE
D PROTEIN 19
(Tetrahymena
thermophila) 		4 / 4 TYR A  94
ASN A 107
ILE A 138
GLN A  31
 None
 1.12A 5hhjA-5doiA:
0.0		 5hhjA-5doiA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5doi TELOMERASE-ASSOCIATE
D PROTEIN 19
(Tetrahymena
thermophila) 		4 / 6 ASP A   9
HIS A 142
ILE A 129
TYR A 130
 None
 1.18A 5ih0A-5doiA:
undetectable		 5ih0A-5doiA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5doi TELOMERASE
ASSOCIATED PROTEIN
P45
TELOMERASE-ASSOCIATE
D PROTEIN 19
(Tetrahymena
thermophila) 		4 / 5 LEU A  10
CYH E  96
LEU E  13
ASP E  54
 None
 1.22A 5mafA-5doiA:
undetectable		 5mafA-5doiA:
18.35