SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5doo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 12 LEU A 140
LEU A 136
LEU A 133
LEU A  48
LEU A 105
None
1.11A 1sqnB-5dooA:
undetectable
1sqnB-5dooA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 10 SER A 522
LEU A 523
PHE A 526
LEU A 473
HIS A 465
None
1.27A 1y7iB-5dooA:
3.0
1y7iB-5dooA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
4 / 8 SER A  68
VAL A  47
PRO A  26
TYR A  65
None
1.06A 2ddwA-5dooA:
2.3
2ddwA-5dooA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
3 / 3 ASN A 304
ILE A 276
MET A 257
None
0.79A 2h42C-5dooA:
undetectable
2h42C-5dooA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 10 THR A  23
LEU A  48
VAL A  73
GLY A  72
GLY A  51
None
1.02A 2wd9C-5dooA:
undetectable
2wd9C-5dooA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 12 THR A 353
MET A 358
ILE A 361
LEU A 362
LEU A 411
None
1.12A 3a51C-5dooA:
undetectable
3a51C-5dooA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 12 ILE A 469
LEU A 495
ALA A 497
ILE A 490
VAL A 518
None
1.05A 3b2rA-5dooA:
undetectable
3b2rA-5dooA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 11 ILE A 469
LEU A 495
ALA A 497
ILE A 490
VAL A 518
None
1.01A 3b2rB-5dooA:
undetectable
3b2rB-5dooA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 12 LEU A  75
ASP A  74
GLY A  53
ASP A  49
GLY A 119
None
0.91A 3cywA-5dooA:
undetectable
3cywA-5dooA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 11 LEU A  75
ASP A  74
ASP A  49
ILE A  50
GLY A 119
None
1.13A 3ebzB-5dooA:
undetectable
3ebzB-5dooA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 9 LEU A  75
ASP A  74
GLY A  53
ASP A  49
GLY A 119
None
1.09A 3gguB-5dooA:
undetectable
3gguB-5dooA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
3 / 3 ASN A 160
ASN A 151
GLU A 223
None
0.74A 3kpdC-5dooA:
undetectable
3kpdC-5dooA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
3 / 3 ASN A 160
ASN A 151
GLU A 223
None
0.91A 3kpdB-5dooA:
undetectable
3kpdB-5dooA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 9 THR A 252
GLY A 250
LEU A 295
LEU A 249
ILE A 145
None
1.43A 3nbqA-5dooA:
undetectable
3nbqA-5dooA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 9 ASP A  74
GLY A  53
ASP A  49
ILE A 102
GLY A 119
None
0.89A 3s53A-5dooA:
undetectable
3s53A-5dooA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
4 / 7 ILE A 462
ILE A 469
GLU A 524
LEU A 532
None
0.70A 3ua5B-5dooA:
0.9
3ua5B-5dooA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 12 LEU A  75
ASP A  74
GLY A  53
ASP A  49
GLY A 119
None
1.04A 3ucbA-5dooA:
undetectable
3ucbA-5dooA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
4 / 5 VAL A 135
LEU A 139
ILE A 115
VAL A  73
None
0.93A 4a9kB-5dooA:
undetectable
4a9kB-5dooA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 12 GLY A  51
GLY A  53
LEU A  75
GLN A  79
VAL A 124
None
1.09A 4f84A-5dooA:
15.3
4f84A-5dooA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
7 / 12 GLY A  51
GLY A  53
LEU A  75
SER A  76
HIS A 118
VAL A 120
VAL A 124
None
1.33A 4htfA-5dooA:
15.7
4htfA-5dooA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
7 / 12 GLY A  51
GLY A  53
LEU A  75
SER A  76
HIS A 118
VAL A 120
VAL A 124
None
1.32A 4htfB-5dooA:
16.0
4htfB-5dooA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
3 / 3 TYR A 150
GLN A 126
TRP A 123
None
1.09A 4kn2C-5dooA:
undetectable
4kn2C-5dooA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
4 / 8 SER A 122
GLN A 129
VAL A 148
THR A 294
None
1.09A 4lnwA-5dooA:
undetectable
4lnwA-5dooA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
4 / 6 ASN A 368
GLU A 381
TYR A 363
GLU A 367
None
1.28A 4mi4A-5dooA:
1.8
4mi4A-5dooA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
4 / 7 ASN A 368
GLU A 381
TYR A 363
GLU A 367
None
1.27A 4mi4A-5dooA:
1.8
4mi4C-5dooA:
undetectable
4mi4A-5dooA:
17.18
4mi4C-5dooA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
4 / 7 ASN A 368
GLU A 381
TYR A 363
GLU A 367
None
1.19A 4mj8C-5dooA:
1.8
4mj8C-5dooA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
3 / 3 PHE A 237
THR A  23
LEU A 136
None
0.75A 4qztA-5dooA:
undetectable
4qztA-5dooA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 12 GLY A  32
GLY A  36
ASN A 304
LEU A  28
ALA A 146
None
1.06A 4uckB-5dooA:
7.7
4uckB-5dooA:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
10 / 12 GLY A  51
LEU A  75
SER A  76
GLN A  79
SER A 101
ILE A 102
HIS A 118
VAL A 120
VAL A 124
VAL A 128
None
0.78A 5dpdA-5dooA:
43.7
5dpdA-5dooA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
10 / 12 GLY A  51
ASP A  74
LEU A  75
SER A  76
GLN A  79
SER A 101
ILE A 102
VAL A 120
VAL A 124
VAL A 128
None
0.84A 5dpdB-5dooA:
43.6
5dpdB-5dooA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 12 GLY A  51
ASP A  74
LEU A  75
SER A  76
VAL A 124
None
0.94A 5dpdB-5dooA:
43.6
5dpdB-5dooA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
8 / 12 GLY A  51
SER A  76
SER A 101
ILE A 102
VAL A 120
TRP A 123
VAL A 124
VAL A 128
None
0.93A 5dpdB-5dooA:
43.6
5dpdB-5dooA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
5 / 12 LEU A  75
SER A  76
SER A 101
ILE A 102
VAL A 120
None
1.14A 5dpdB-5dooA:
43.6
5dpdB-5dooA:
42.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
4 / 7 SER A 253
ASP A 251
PHE A 147
SER A  21
None
1.26A 5l1fC-5dooA:
undetectable
5l1fC-5dooA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi)
4 / 7 TYR A 121
ILE A 132
ASP A  74
GLY A  51
None
0.84A 5nooA-5dooA:
undetectable
5nooA-5dooA:
19.85