SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 PHE A 192
VAL A 190
ILE A 173
PRO A 195
GLY A  69
 None
 1.23A 13gsA-5dotA:
undetectable		 13gsA-5dotA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 PHE A 192
VAL A 190
ILE A 173
PRO A 195
GLY A  69
 None
 1.23A 13gsB-5dotA:
undetectable		 13gsB-5dotA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
 None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
 1.30A 1a4gA-5dotA:
undetectable		 1a4gA-5dotA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A1296
ILE A1230
ALA A1180
VAL A1242
LEU A1271
 None
 0.88A 1cbsA-5dotA:
undetectable		 1cbsA-5dotA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLN A 318
PRO A 384
GLU A 763
GLU A 950
 None
 1.12A 1dtlA-5dotA:
undetectable		 1dtlA-5dotA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LYS A 182
GLU A 184
ALA A  68
LEU A 180
 None
 1.18A 1eta1-5dotA:
undetectable		 1eta1-5dotA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 150
LEU A 153
GLY A 102
LEU A  94
VAL A 128
 None
 0.98A 1fduA-5dotA:
4.7		 1fduA-5dotA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU A 545
ASN A 698
ASP A 442
GLY A 510
ALA A 724
 None
 1.31A 1hvyB-5dotA:
undetectable		 1hvyB-5dotA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 GLY A 439
GLY A 432
GLY A 510
GLY A 509
ASP A 442
 None
 1.04A 1mxdA-5dotA:
undetectable		 1mxdA-5dotA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A 439
GLY A 432
GLY A 510
GLY A 509
ASP A 442
 None
 1.02A 1mxgA-5dotA:
undetectable		 1mxgA-5dotA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 MET A 313
ASN A 315
GLY A 317
LEU A 947
THR A 360
 None
NI  A1601 (-3.3A)
None
None
None
 1.47A 1p93B-5dotA:
undetectable		 1p93B-5dotA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A1357
LEU A1464
PHE A1473
ILE A1362
LEU A1381
 None
 1.34A 1rh3A-5dotA:
2.5		 1rh3A-5dotA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 526
LEU A 520
GLN A 490
LEU A 426
MET A 462
 None
 1.46A 1sqnA-5dotA:
undetectable		 1sqnA-5dotA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A1309
ASP A 993
CYH A 981
 None
 1.36A 2br4F-5dotA:
4.8		 2br4F-5dotA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 410
ILE A 406
VAL A 374
GLY A 363
LEU A 390
 None
 0.96A 2bxeB-5dotA:
undetectable		 2bxeB-5dotA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A1296
ILE A1230
ALA A1180
VAL A1242
LEU A1271
 None
 0.92A 2fr3A-5dotA:
undetectable		 2fr3A-5dotA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ASN A 752
ILE A 750
THR A 758
ASN A 357
VAL A 637
 None
 1.46A 2gl0B-5dotA:
undetectable
2gl0C-5dotA:
undetectable		 2gl0B-5dotA:
8.13
2gl0C-5dotA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TYR A 768
ASP A 767
TYR A 959
HIS A 967
 None
 1.29A 2ha2A-5dotA:
undetectable		 2ha2A-5dotA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TYR A 768
ASP A 767
TYR A 959
HIS A 967
 None
 1.32A 2ha2B-5dotA:
undetectable		 2ha2B-5dotA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLU A 440
PRO A 464
MET A 462
GLY A 509
 None
 1.21A 2hs1B-5dotA:
undetectable		 2hs1B-5dotA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LYS A 740
GLU A 455
ILE A 745
ILE A 750
 None
 0.93A 2j9dJ-5dotA:
undetectable
2j9dK-5dotA:
undetectable
2j9dL-5dotA:
undetectable		 2j9dJ-5dotA:
5.87
2j9dK-5dotA:
5.87
2j9dL-5dotA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A1019
VAL A 997
VAL A1012
VAL A 978
 None
 0.86A 2qbnA-5dotA:
undetectable		 2qbnA-5dotA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 100
PHE A 877
ASP A 874
GLU A 651
 None
 1.03A 2qebA-5dotA:
undetectable		 2qebA-5dotA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 288
PRO A 289
ILE A 398
GLY A 258
 None
 1.12A 2qeuA-5dotA:
undetectable
2qeuC-5dotA:
undetectable		 2qeuA-5dotA:
6.28
2qeuC-5dotA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 526
LEU A 520
GLN A 490
LEU A 426
MET A 462
 None
 1.48A 2w8yB-5dotA:
undetectable		 2w8yB-5dotA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TYR A 962
GLU A1038
THR A 928
 None
EDO  A1603 (-3.3A)
None
 0.97A 2y7hB-5dotA:
2.5		 2y7hB-5dotA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ARG A 932
ASP A1042
ILE A1043
GLU A1034
 None
None
None
EDO  A1603 (-2.7A)
 1.41A 2ya7C-5dotA:
undetectable		 2ya7C-5dotA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ARG A 718
GLU A 696
GLU A 635
SER A 723
 None
 1.06A 2zt7A-5dotA:
2.8		 2zt7A-5dotA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 274
ASN A 199
GLY A 226
THR A 295
ILE A 299
 None
None
EDO  A1606 ( 4.1A)
None
None
 1.41A 3bexC-5dotA:
undetectable
3bexD-5dotA:
undetectable		 3bexC-5dotA:
10.28
3bexD-5dotA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASN A 199
GLY A 226
THR A 295
ILE A 299
LEU A 274
 None
EDO  A1606 ( 4.1A)
None
None
None
 1.41A 3bexE-5dotA:
undetectable
3bexF-5dotA:
undetectable		 3bexE-5dotA:
10.28
3bexF-5dotA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A 274
ASN A 199
GLY A 226
THR A 295
ILE A 299
 None
None
EDO  A1606 ( 4.1A)
None
None
 1.38A 3bf1C-5dotA:
undetectable
3bf1D-5dotA:
2.5		 3bf1C-5dotA:
10.28
3bf1D-5dotA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 GLY A 510
GLY A 509
GLY A 429
ILE A 427
SER A 444
 None
 1.46A 3d41A-5dotA:
undetectable		 3d41A-5dotA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 526
LEU A 520
GLN A 490
LEU A 426
MET A 462
 None
 1.46A 3d90A-5dotA:
undetectable		 3d90A-5dotA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 911
PHE A 823
PHE A 805
THR A 804
LEU A 134
 None
None
None
EDO  A1604 ( 4.7A)
None
 1.14A 3dh0A-5dotA:
2.2		 3dh0A-5dotA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ILE A 161
ILE A 183
VAL A  67
GLY A  69
LEU A 169
 None
 1.28A 3elzC-5dotA:
undetectable		 3elzC-5dotA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 HIS A  63
LYS A 157
ILE A 126
TYR A  80
 None
 1.01A 3eteD-5dotA:
undetectable
3eteF-5dotA:
undetectable		 3eteD-5dotA:
16.67
3eteF-5dotA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A 997
VAL A1012
THR A1019
VAL A 469
 None
 1.09A 3fhxB-5dotA:
4.4		 3fhxB-5dotA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 VAL A 223
ILE A 281
ILE A 261
LEU A 260
 None
 0.66A 3hegA-5dotA:
undetectable		 3hegA-5dotA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A1174
ILE A1192
THR A1270
 None
 0.71A 3ia4D-5dotA:
undetectable		 3ia4D-5dotA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 514
VAL A 457
ILE A 427
ARG A 419
 None
 1.28A 3ik3A-5dotA:
undetectable		 3ik3A-5dotA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 514
VAL A 457
ILE A 427
ARG A 419
 None
 1.27A 3ik3B-5dotA:
undetectable		 3ik3B-5dotA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 PRO A 268
LEU A 274
ILE A 299
SER A 294
GLY A 296
 None
 1.44A 3iluB-5dotA:
undetectable
3iluE-5dotA:
undetectable		 3iluB-5dotA:
11.09
3iluE-5dotA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ARG A1453
SER A1314
LEU A1438
PRO A1439
 None
 0.94A 3jq7B-5dotA:
6.0		 3jq7B-5dotA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A1016
ASP A 993
ARG A 718
 None
 0.92A 3k13C-5dotA:
undetectable		 3k13C-5dotA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
 None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
 1.36A 3k39C-5dotA:
undetectable		 3k39C-5dotA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
 None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
 1.34A 3k39I-5dotA:
undetectable		 3k39I-5dotA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
 None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
 1.36A 3k39J-5dotA:
undetectable		 3k39J-5dotA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
 None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
 1.35A 3k39K-5dotA:
undetectable		 3k39K-5dotA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
 None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
 1.36A 3k39L-5dotA:
undetectable		 3k39L-5dotA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A  91
GLY A 264
GLY A 266
ALA A  88
ASN A 336
 None
 0.98A 3kkzB-5dotA:
undetectable		 3kkzB-5dotA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLN A 375
LEU A 290
GLY A 305
ALA A 304
LEU A 282
 None
 1.02A 3ln1A-5dotA:
undetectable		 3ln1A-5dotA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 425
ALA A 513
GLY A 535
ALA A 742
LEU A 743
 None
 0.95A 3ln1A-5dotA:
undetectable		 3ln1A-5dotA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLN A 375
LEU A 290
GLY A 305
ALA A 304
LEU A 282
 None
 1.01A 3ln1B-5dotA:
undetectable		 3ln1B-5dotA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 425
ALA A 513
GLY A 535
ALA A 742
LEU A 743
 None
 0.94A 3ln1B-5dotA:
undetectable		 3ln1B-5dotA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 425
ALA A 513
GLY A 535
ALA A 742
LEU A 743
 None
 0.95A 3ln1C-5dotA:
undetectable		 3ln1C-5dotA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLN A 375
LEU A 290
GLY A 305
ALA A 304
LEU A 282
 None
 1.02A 3ln1D-5dotA:
undetectable		 3ln1D-5dotA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 425
ALA A 513
GLY A 535
ALA A 742
LEU A 743
 None
 0.95A 3ln1D-5dotA:
undetectable		 3ln1D-5dotA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_B_ACTB600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ARG A1262
ALA A1206
GLU A1175
HIS A1195
 None
 1.07A 3mbgB-5dotA:
undetectable
3mbgC-5dotA:
undetectable		 3mbgB-5dotA:
6.82
3mbgC-5dotA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A1175
HIS A1195
ARG A1262
ALA A1206
 None
 1.07A 3mbgB-5dotA:
undetectable
3mbgC-5dotA:
undetectable		 3mbgB-5dotA:
6.82
3mbgC-5dotA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASN A  98
GLY A  76
GLN A 318
LEU A 672
ILE A 100
 None
 1.31A 3mnoA-5dotA:
undetectable		 3mnoA-5dotA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASN A  98
GLY A  76
GLN A 318
LEU A 672
ILE A 100
 None
 1.32A 3mnpA-5dotA:
undetectable		 3mnpA-5dotA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A1445
ILE A1366
PHE A1370
PHE A1374
THR A1394
 None
 1.25A 3ndiA-5dotA:
undetectable		 3ndiA-5dotA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 VAL A1477
PHE A1489
GLY A1339
TYR A1494
ILE A1342
 None
 1.16A 3owxA-5dotA:
undetectable
3owxB-5dotA:
undetectable		 3owxA-5dotA:
9.51
3owxB-5dotA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 VAL A 231
ILE A 293
GLY A 296
ILE A 299
ALA A 222
 None
 1.02A 3t3cB-5dotA:
undetectable		 3t3cB-5dotA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLN A 470
GLY A 431
GLY A 429
SER A1352
GLU A 440
 None
 1.36A 3t7sC-5dotA:
undetectable		 3t7sC-5dotA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 264
GLY A 266
ALA A  88
TYR A  89
ASN A 336
 None
 1.34A 3t7sC-5dotA:
undetectable		 3t7sC-5dotA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ILE A 801
THR A 955
SER A 953
ILE A 944
THR A 961
 None
 0.98A 3um5A-5dotA:
2.2		 3um5A-5dotA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 233
GLU A 379
THR A 381
 None
 0.86A 3v4tA-5dotA:
undetectable		 3v4tA-5dotA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ASN A1016
ARG A1259
ASN A1062
GLY A 980
GLY A 987
 None
 1.14A 4a6nC-5dotA:
3.8		 4a6nC-5dotA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
 None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
 1.34A 4b7qD-5dotA:
undetectable		 4b7qD-5dotA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
 None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
 1.33A 4cpnA-5dotA:
undetectable		 4cpnA-5dotA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
 None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
 1.36A 4cpnB-5dotA:
undetectable		 4cpnB-5dotA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
 None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
 1.28A 4cpzC-5dotA:
undetectable		 4cpzC-5dotA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
 None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
 1.24A 4cpzG-5dotA:
undetectable		 4cpzG-5dotA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LYS A 856
LEU A 839
ALA A 853
THR A 849
 None
 1.20A 4d7bB-5dotA:
undetectable		 4d7bB-5dotA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE A 466
ALA A1336
GLU A 991
GLY A 432
ASN A 465
 None
 1.28A 4e47C-5dotA:
undetectable		 4e47C-5dotA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_D_SAMD800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ILE A 466
ALA A1336
GLU A 991
GLY A 432
ASN A 465
 None
 1.26A 4e47D-5dotA:
undetectable		 4e47D-5dotA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A1339
TYR A1494
ILE A1342
VAL A1477
PHE A1489
 None
 1.18A 4fglA-5dotA:
2.9
4fglB-5dotA:
3.8		 4fglA-5dotA:
9.80
4fglB-5dotA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLY A  79
GLY A  78
ASN A  98
GLU A  82
 None
 1.00A 4fglC-5dotA:
0.6		 4fglC-5dotA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A  79
GLY A  78
ASN A  98
GLU A  82
 None
 0.98A 4fglD-5dotA:
undetectable		 4fglD-5dotA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PHE A 805
VAL A 666
GLU A 651
 None
 0.43A 4fvqA-5dotA:
undetectable		 4fvqA-5dotA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A 317
ASN A 357
GLU A 950
GLN A 678
 None
 1.18A 4g0vB-5dotA:
0.9		 4g0vB-5dotA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
 None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
 1.23A 4i00A-5dotA:
undetectable		 4i00A-5dotA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA A1279
ILE A1188
VAL A1288
PRO A1294
VAL A1181
 None
 1.04A 4j5jB-5dotA:
undetectable		 4j5jB-5dotA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE A 466
ALA A1336
GLU A 991
GLY A 432
ASN A 465
 None
 1.28A 4j83A-5dotA:
0.3		 4j83A-5dotA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE A 466
ALA A1336
GLU A 991
GLY A 432
ASN A 465
 None
 1.26A 4jdsC-5dotA:
undetectable		 4jdsC-5dotA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE A 466
ALA A1336
GLU A 991
GLY A 432
ASN A 465
 None
 1.24A 4jdsD-5dotA:
undetectable		 4jdsD-5dotA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A1308
GLU A1475
ALA A1349
VAL A1477
 None
 0.84A 4jltA-5dotA:
undetectable		 4jltA-5dotA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ARG A 718
GLU A 696
GLU A 635
SER A 723
 None
 1.41A 4kr3A-5dotA:
1.0		 4kr3A-5dotA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ILE A 227
GLY A 226
ILE A 201
ILE A 259
VAL A 221
 None
EDO  A1606 ( 4.1A)
None
None
None
 1.04A 4nptA-5dotA:
undetectable		 4nptA-5dotA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ALA A1336
ALA A 467
ILE A1342
GLY A1339
ALA A1307
 None
 1.06A 4qvqK-5dotA:
undetectable
4qvqL-5dotA:
undetectable		 4qvqK-5dotA:
9.73
4qvqL-5dotA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ALA A1336
ALA A 467
ILE A1342
GLY A1339
ALA A1307
 None
 1.06A 4qvqY-5dotA:
undetectable
4qvqZ-5dotA:
undetectable		 4qvqY-5dotA:
9.73
4qvqZ-5dotA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A1034
ARG A1039
GLN A 916
 EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
None
 0.84A 4rtbA-5dotA:
undetectable		 4rtbA-5dotA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 980
TYR A 984
SER A 988
ASN A1014
 None
 1.04A 4wryA-5dotA:
undetectable		 4wryA-5dotA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 980
TYR A 984
SER A 988
ASN A1014
 None
 0.99A 4wrzA-5dotA:
undetectable		 4wrzA-5dotA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WZM_A_ACTA503_0
(RNA DEPENDENT RNA
POLYMERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ASP A 767
ASP A 945
ASP A 968
ALA A 948
 None
 1.10A 4wzmA-5dotA:
2.4		 4wzmA-5dotA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 561
PHE A 550
ARG A 547
ILE A 713
 None
 1.29A 4zzcA-5dotA:
undetectable
4zzcB-5dotA:
undetectable		 4zzcA-5dotA:
12.46
4zzcB-5dotA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE A 466
ALA A1336
GLU A 991
GLY A 432
ASN A 465
 None
 1.22A 5ayfA-5dotA:
undetectable		 5ayfA-5dotA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLU A 455
GLY A 509
ASP A 442
GLY A 507
 None
 0.90A 5cdnR-5dotA:
undetectable
5cdnS-5dotA:
2.3		 5cdnR-5dotA:
16.67
5cdnS-5dotA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A1347
ALA A1345
LEU A1488
VAL A1306
 None
 1.09A 5cr1A-5dotA:
undetectable		 5cr1A-5dotA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 401
GLY A 305
GLY A 301
LEU A 290
THR A 404
 None
 1.05A 5eqbA-5dotA:
undetectable		 5eqbA-5dotA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 906
THR A 804
ASP A 135
 EDO  A1604 (-3.8A)
EDO  A1604 ( 4.7A)
EDO  A1604 (-4.3A)
 0.93A 5g5gA-5dotA:
undetectable
5g5gB-5dotA:
undetectable		 5g5gA-5dotA:
9.82
5g5gB-5dotA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 422
LEU A 743
ALA A 742
ILE A 487
MET A 462
 None
 1.11A 5hbsA-5dotA:
undetectable		 5hbsA-5dotA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE A 227
GLY A 226
CYH A 225
ALA A 262
GLU A 379
 None
EDO  A1606 ( 4.1A)
None
None
None
 1.31A 5hw4B-5dotA:
undetectable		 5hw4B-5dotA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 PHE A 192
VAL A  49
ILE A  48
ILE A 172
ILE A 173
 None
 1.21A 5hw8G-5dotA:
undetectable		 5hw8G-5dotA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 293
GLY A 292
ASP A  86
HIS A 377
ILE A 201
 None
 1.27A 5igwA-5dotA:
1.4		 5igwA-5dotA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLN A 375
LEU A 290
GLY A 305
ALA A 304
LEU A 282
 None
 1.00A 5jw1A-5dotA:
undetectable		 5jw1A-5dotA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 425
ALA A 513
GLY A 535
ALA A 742
LEU A 743
 None
 0.97A 5jw1A-5dotA:
undetectable		 5jw1A-5dotA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLN A 375
LEU A 290
GLY A 305
ALA A 304
LEU A 282
 None
 1.05A 5jw1B-5dotA:
undetectable		 5jw1B-5dotA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 425
ALA A 513
GLY A 535
ALA A 742
LEU A 743
 None
 0.96A 5kirA-5dotA:
undetectable		 5kirA-5dotA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 425
ALA A 513
GLY A 535
ALA A 742
LEU A 743
 None
 0.95A 5kirB-5dotA:
undetectable		 5kirB-5dotA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ILE A 281
ILE A 259
VAL A 278
THR A 300
ILE A 261
 None
 1.26A 5lg3G-5dotA:
undetectable		 5lg3G-5dotA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ILE A 281
ILE A 259
VAL A 278
THR A 300
ILE A 261
 None
 1.26A 5lg3H-5dotA:
undetectable		 5lg3H-5dotA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 TYR A  80
SER A 148
ALA A 106
THR A 109
 None
 1.31A 5n0tA-5dotA:
undetectable		 5n0tA-5dotA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 VAL A 645
ILE A 741
ILE A 737
ILE A 750
ALA A 330
 None
 1.00A 5nunA-5dotA:
undetectable		 5nunA-5dotA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A 366
GLU A 367
TRP A 349
 None
 1.22A 5odiD-5dotA:
2.1		 5odiD-5dotA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LEU A 433
VAL A1457
ASP A1458
 None
 0.59A 5x23A-5dotA:
undetectable		 5x23A-5dotA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A1266
GLU A1334
VAL A1335
THR A1207
GLU A1197
 None
 1.48A 5xiqC-5dotA:
3.2		 5xiqC-5dotA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A1089
PHE A1169
ARG A1129
 None
 1.24A 5y9yA-5dotA:
undetectable		 5y9yA-5dotA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 858
ILE A 851
LEU A 885
ILE A 873
LEU A 843
 None
 1.09A 6a5zD-5dotA:
undetectable		 6a5zD-5dotA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 858
ILE A 851
PHE A 823
ILE A 873
LEU A 843
 None
 0.99A 6a5zD-5dotA:
undetectable		 6a5zD-5dotA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 291
ILE A 406
VAL A 409
VAL A 374
PHE A 372
 None
 1.28A 6ap6A-5dotA:
undetectable		 6ap6A-5dotA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 291
ILE A 406
VAL A 409
VAL A 374
PHE A 372
 None
 1.28A 6ap6B-5dotA:
undetectable		 6ap6B-5dotA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A1208
HIS A1195
PRO A1311
SER A1331
VAL A1201
 None
 1.44A 6b89B-5dotA:
undetectable		 6b89B-5dotA:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A1129
LYS A1139
ARG A1453
 None
 0.99A 6c06D-5dotA:
undetectable		 6c06D-5dotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ILE A1192
SER A1193
ALA A1180
LEU A1296
 None
 0.98A 6dwnA-5dotA:
undetectable		 6dwnA-5dotA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A1357
LEU A1488
ARG A1481
SER A1485
 None
 1.07A 6f6jA-5dotA:
undetectable		 6f6jA-5dotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A1488
THR A1344
GLY A1339
ARG A1492
 None
 1.36A 6gtqB-5dotA:
undetectable
6gtqD-5dotA:
undetectable		 6gtqB-5dotA:
8.96
6gtqD-5dotA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 271
ALA A 306
GLY A 301
THR A 300
ALA A 303
 None
 1.02A 6hwdH-5dotA:
undetectable
6hwdI-5dotA:
undetectable		 6hwdH-5dotA:
4.34
6hwdI-5dotA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA A 271
ALA A 306
GLY A 301
THR A 300
ALA A 303
 None
 1.02A 6hwdV-5dotA:
undetectable		 6hwdV-5dotA:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 PHE A 376
ASN A 674
GLY A 317
ASN A 319
ALA A  83
 None
 1.36A 6r2eF-5dotA:
undetectable		 6r2eF-5dotA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A1060
TYR A 984
GLY A 980
ASN A1014
ALA A1260
 None
 1.27A 6r2eH-5dotA:
undetectable		 6r2eH-5dotA:
12.27