SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5doz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 5doz JAMJ
(Lyngbya
majuscula) 		4 / 4 VAL A 332
ALA A 317
LEU A  19
PHE A 318
 None
 1.07A 1q97B-5dozA:
undetectable		 1q97B-5dozA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 5doz JAMJ
(Lyngbya
majuscula) 		4 / 5 TRP A  21
THR A  72
GLN A   7
ILE A  38
 None
 1.30A 1ss4A-5dozA:
undetectable		 1ss4A-5dozA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 5doz JAMJ
(Lyngbya
majuscula) 		6 / 12 GLY A 165
GLY A 163
ALA A 159
THR A 182
ALA A 181
ALA A 168
 None
NDP  A 502 (-3.7A)
NDP  A 502 (-3.3A)
None
None
None
 1.36A 2gluB-5dozA:
8.6		 2gluB-5dozA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5doz JAMJ
(Lyngbya
majuscula) 		5 / 7 LEU A 124
GLU A 128
ILE A 132
ALA A 160
ILE A 157
 None
 1.44A 2xkwA-5dozA:
undetectable		 2xkwA-5dozA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5doz JAMJ
(Lyngbya
majuscula) 		4 / 7 LEU A 191
ILE A 327
ALA A 130
ILE A 127
 None
 0.85A 2xkwA-5dozA:
undetectable		 2xkwA-5dozA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5doz JAMJ
(Lyngbya
majuscula) 		3 / 3 ASP A 281
PHE A 278
LEU A 274
 None
None
NDP  A 502 (-3.9A)
 0.69A 2zi9A-5dozA:
undetectable		 2zi9A-5dozA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5doz JAMJ
(Lyngbya
majuscula) 		5 / 9 GLN A 170
ILE A 149
VAL A 155
VAL A 179
GLN A 173
 None
 1.24A 3fi0O-5dozA:
2.3		 3fi0O-5dozA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5doz JAMJ
(Lyngbya
majuscula) 		4 / 8 SER A 226
ALA A 159
SER A 202
ARG A 203
 NDP  A 502 (-3.7A)
NDP  A 502 (-3.3A)
NDP  A 502 (-2.4A)
NDP  A 502 (-3.4A)
 1.04A 4lv9A-5dozA:
undetectable
4lv9B-5dozA:
undetectable		 4lv9A-5dozA:
22.48
4lv9B-5dozA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5doz JAMJ
(Lyngbya
majuscula) 		4 / 7 SER A 226
ALA A 159
SER A 202
ARG A 203
 NDP  A 502 (-3.7A)
NDP  A 502 (-3.3A)
NDP  A 502 (-2.4A)
NDP  A 502 (-3.4A)
 1.03A 4lv9A-5dozA:
1.5
4lv9B-5dozA:
undetectable		 4lv9A-5dozA:
22.48
4lv9B-5dozA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5doz JAMJ
(Lyngbya
majuscula) 		4 / 7 GLU A 213
THR A 215
THR A 182
HIS A 158
 None
 1.10A 4pfjA-5dozA:
9.8		 4pfjA-5dozA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5doz JAMJ
(Lyngbya
majuscula) 		4 / 6 GLU A 213
THR A 215
THR A 182
HIS A 158
 None
 1.07A 4pfjB-5dozA:
9.9		 4pfjB-5dozA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5doz JAMJ
(Lyngbya
majuscula) 		4 / 6 GLU A 213
THR A 215
THR A 182
HIS A 158
 None
 1.11A 4pgfA-5dozA:
9.7		 4pgfA-5dozA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5doz JAMJ
(Lyngbya
majuscula) 		5 / 12 PHE A  73
GLY A  74
LEU A  24
ILE A  38
MET A 334
 None
 1.26A 5y2tA-5dozA:
undetectable		 5y2tA-5dozA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 5doz JAMJ
(Lyngbya
majuscula) 		5 / 12 LEU A 214
VAL A 239
ILE A 223
LEU A 240
ILE A 211
 None
 1.04A 6dh6B-5dozA:
undetectable		 6dh6B-5dozA:
13.61