SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 12 GLU A 279
LEU A 294
LEU A 290
MET A 276
PHE A 274
 None
None
None
NAP  A 401 (-4.9A)
None
 1.43A 1d4fA-5dp2A:
10.1		 1d4fA-5dp2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 12 GLU A 279
LEU A 294
LEU A 290
MET A 276
PHE A 274
 None
None
None
NAP  A 401 (-4.9A)
None
 1.41A 1d4fB-5dp2A:
4.2		 1d4fB-5dp2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 12 GLU A 279
LEU A 294
LEU A 290
MET A 276
PHE A 274
 None
None
None
NAP  A 401 (-4.9A)
None
 1.45A 1d4fD-5dp2A:
5.2		 1d4fD-5dp2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 5dp2 CURF
(Lyngbya
majuscula) 		4 / 8 PHE A 320
PHE A 108
ALA A 319
ILE A 332
 None
 1.04A 1pnlA-5dp2A:
undetectable
1pnlB-5dp2A:
0.5		 1pnlA-5dp2A:
20.92
1pnlB-5dp2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 9 PHE A 135
PHE A 298
LEU A 173
PHE A 226
LEU A 294
 None
 1.37A 1wrkA-5dp2A:
undetectable
1wrkB-5dp2A:
undetectable		 1wrkA-5dp2A:
14.20
1wrkB-5dp2A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 5dp2 CURF
(Lyngbya
majuscula) 		6 / 12 GLY A 167
GLY A 165
ALA A 161
THR A 184
ALA A 183
ALA A 170
 None
NAP  A 401 (-3.5A)
NAP  A 401 ( 3.7A)
None
None
None
 1.33A 2gluB-5dp2A:
8.9		 2gluB-5dp2A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 12 PHE A 280
MET A 276
PHE A 274
ALA A 141
LEU A 294
 None
NAP  A 401 (-4.9A)
None
None
None
 1.19A 2x2nB-5dp2A:
undetectable		 2x2nB-5dp2A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 12 PHE A 280
MET A 276
PHE A 274
ALA A 141
LEU A 294
 None
NAP  A 401 (-4.9A)
None
None
None
 1.11A 2x2nC-5dp2A:
undetectable		 2x2nC-5dp2A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 12 PHE A 280
MET A 276
PHE A 274
ALA A 141
LEU A 294
 None
NAP  A 401 (-4.9A)
None
None
None
 1.13A 2x2nD-5dp2A:
undetectable		 2x2nD-5dp2A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5dp2 CURF
(Lyngbya
majuscula) 		4 / 8 SER A 326
GLN A 168
ILE A 332
SER A 163
 NAP  A 401 (-2.5A)
None
None
NAP  A 401 (-2.6A)
 1.13A 2xz5B-5dp2A:
undetectable
2xz5E-5dp2A:
undetectable		 2xz5B-5dp2A:
23.30
2xz5E-5dp2A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 9 VAL A 171
GLY A 165
GLY A 164
LEU A 173
ALA A 141
 None
NAP  A 401 (-3.5A)
NAP  A 401 (-3.2A)
None
None
 0.97A 2z0yA-5dp2A:
3.4		 2z0yA-5dp2A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5dp2 CURF
(Lyngbya
majuscula) 		6 / 9 ALA A 169
VAL A 171
GLY A 165
GLY A 164
LEU A 173
ALA A 141
 None
None
NAP  A 401 (-3.5A)
NAP  A 401 (-3.2A)
None
None
 1.23A 2z0yB-5dp2A:
2.9		 2z0yB-5dp2A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5dp2 CURF
(Lyngbya
majuscula) 		4 / 8 ARG A 266
VAL A 269
VAL A 222
ILE A 225
 None
 1.02A 3remA-5dp2A:
undetectable		 3remA-5dp2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5dp2 CURF
(Lyngbya
majuscula) 		4 / 8 ARG A 266
VAL A 269
VAL A 222
ILE A 225
 None
 1.00A 3remB-5dp2A:
undetectable		 3remB-5dp2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 9 LEU A 216
ARG A 214
VAL A 222
LEU A 158
ALA A 210
 None
 1.25A 3uncB-5dp2A:
undetectable		 3uncB-5dp2A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 11 VAL A 171
GLY A 330
VAL A 192
LEU A 193
GLY A 164
 None
None
None
None
NAP  A 401 (-3.2A)
 1.17A 3zosA-5dp2A:
undetectable
3zosB-5dp2A:
undetectable		 3zosA-5dp2A:
21.98
3zosB-5dp2A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5dp2 CURF
(Lyngbya
majuscula) 		4 / 8 PHE A 177
ALA A 141
LEU A 294
LEU A 303
 None
 0.66A 4ejgB-5dp2A:
undetectable		 4ejgB-5dp2A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 5dp2 CURF
(Lyngbya
majuscula) 		4 / 7 PHE A 177
ALA A 141
LEU A 294
LEU A 303
 None
 0.60A 4ejgC-5dp2A:
undetectable		 4ejgC-5dp2A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5dp2 CURF
(Lyngbya
majuscula) 		4 / 8 PHE A 177
SER A 179
ALA A 170
LEU A 173
 None
 1.02A 4rkuA-5dp2A:
undetectable
4rkuJ-5dp2A:
undetectable		 4rkuA-5dp2A:
18.78
4rkuJ-5dp2A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5dp2 CURF
(Lyngbya
majuscula) 		4 / 7 PHE A 177
SER A 179
ALA A 170
LEU A 173
 None
 0.99A 4xk8A-5dp2A:
undetectable		 4xk8A-5dp2A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 12 ILE A 249
ALA A 149
ARG A 247
ALA A 174
PHE A 274
 None
 1.39A 4zo1X-5dp2A:
undetectable		 4zo1X-5dp2A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5dp2 CURF
(Lyngbya
majuscula) 		3 / 3 ARG A 282
TYR A 143
GLU A 279
 None
 0.66A 4zzbE-5dp2A:
undetectable		 4zzbE-5dp2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 11 LEU A 323
GLY A  76
GLU A  47
ASN A  44
VAL A  51
 None
None
None
NAP  A 401 ( 4.7A)
None
 1.15A 5hjiA-5dp2A:
9.2		 5hjiA-5dp2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 5dp2 CURF
(Lyngbya
majuscula) 		5 / 12 VAL A 222
ILE A 241
ILE A 235
PHE A 209
ILE A 251
 None
None
None
None
NAP  A 401 (-3.8A)
 1.04A 5hw8B-5dp2A:
undetectable
5hw8F-5dp2A:
undetectable
5hw8G-5dp2A:
undetectable		 5hw8B-5dp2A:
18.71
5hw8F-5dp2A:
18.71
5hw8G-5dp2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5dp2 CURF
(Lyngbya
majuscula) 		4 / 8 PRO A 104
ILE A  38
VAL A  36
ILE A 100
 None
 0.81A 5mzrE-5dp2A:
undetectable		 5mzrE-5dp2A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5dp2 CURF
(Lyngbya
majuscula) 		4 / 7 ILE A 100
GLU A 130
VAL A  80
TRP A  93
 None
 1.15A 6j20A-5dp2A:
undetectable		 6j20A-5dp2A:
22.78