SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dpd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
3 / 3 VAL A  91
ALA A  90
HIS A  97
None
0.64A 1q23G-5dpdA:
undetectable
1q23G-5dpdA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
3 / 3 VAL A  91
ALA A  90
HIS A  97
None
0.65A 1q23J-5dpdA:
undetectable
1q23J-5dpdA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
3 / 3 ASN A 332
ILE A 304
MET A 285
None
0.76A 2h42C-5dpdA:
undetectable
2h42C-5dpdA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
5 / 11 GLU A 308
LEU A 287
MET A 290
ARG A 320
ASP A 312
None
1.49A 2no6B-5dpdA:
undetectable
2no6B-5dpdA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
5 / 12 GLY A  79
ALA A  81
GLY A  83
LEU A 103
THR A 131
SAM  A 601 (-3.8A)
None
None
SAM  A 601 (-4.2A)
None
0.90A 2nyuB-5dpdA:
11.1
2nyuB-5dpdA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 7 THR A 468
PRO A 469
SER A 470
GLU A 110
None
1.02A 2v2gA-5dpdA:
undetectable
2v2gB-5dpdA:
undetectable
2v2gA-5dpdA:
17.58
2v2gB-5dpdA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 7 THR A 468
PRO A 469
SER A 470
GLU A 110
None
1.03A 2v2gA-5dpdA:
undetectable
2v2gB-5dpdA:
undetectable
2v2gA-5dpdA:
17.58
2v2gB-5dpdA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 7 THR A 468
PRO A 469
SER A 470
GLU A 110
None
1.03A 2v2gC-5dpdA:
undetectable
2v2gD-5dpdA:
undetectable
2v2gC-5dpdA:
17.58
2v2gD-5dpdA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 7 THR A 468
PRO A 469
SER A 470
GLU A 110
None
1.02A 2v2gC-5dpdA:
undetectable
2v2gD-5dpdA:
undetectable
2v2gC-5dpdA:
17.58
2v2gD-5dpdA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 8 THR A 468
PRO A 469
SER A 470
GLU A 110
None
0.97A 2v41C-5dpdA:
undetectable
2v41D-5dpdA:
undetectable
2v41C-5dpdA:
17.58
2v41D-5dpdA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 7 THR A 468
PRO A 469
SER A 470
GLU A 110
None
1.06A 2v41E-5dpdA:
undetectable
2v41F-5dpdA:
undetectable
2v41E-5dpdA:
17.58
2v41F-5dpdA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 8 THR A 468
PRO A 469
SER A 470
GLU A 110
None
0.99A 2v41G-5dpdA:
undetectable
2v41H-5dpdA:
undetectable
2v41G-5dpdA:
17.58
2v41H-5dpdA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1469_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 4 GLN A 405
GLU A 409
LEU A 401
SER A 402
None
1.44A 2xrzA-5dpdA:
1.1
2xrzA-5dpdA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 7 PRO A  88
PHE A 125
ILE A 123
GLY A  83
None
0.78A 2y7kA-5dpdA:
undetectable
2y7kA-5dpdA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
5 / 12 GLY A  79
GLY A  83
GLY A  84
LEU A 103
ILE A 130
SAM  A 601 (-3.8A)
None
None
SAM  A 601 (-4.2A)
SAM  A 601 (-3.9A)
0.65A 3douA-5dpdA:
10.7
3douA-5dpdA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 6 ASN A 114
ILE A  87
GLU A 110
ASN A 112
None
1.33A 3kp6A-5dpdA:
undetectable
3kp6B-5dpdA:
undetectable
3kp6A-5dpdA:
15.49
3kp6B-5dpdA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
3 / 3 ASN A 372
ASN A 398
GLU A 479
None
0.84A 3kpdC-5dpdA:
undetectable
3kpdC-5dpdA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
3 / 3 ASN A 372
ASN A 398
GLU A 479
None
0.83A 3kpdB-5dpdA:
undetectable
3kpdB-5dpdA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
5 / 12 LEU A  56
LEU A  59
ALA A  60
LEU A 277
ILE A 143
None
1.08A 3q95B-5dpdA:
undetectable
3q95B-5dpdA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 5 LEU A  56
HIS A  55
HIS A  89
HIS A 478
None
1.23A 4a7bB-5dpdA:
undetectable
4a7bB-5dpdA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 4 GLU A 308
ASP A 312
ARG A 270
THR A 180
None
1.50A 4ej1A-5dpdA:
undetectable
4ej1A-5dpdA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
5 / 11 HIS A 126
ILE A 123
GLY A  83
GLY A  84
GLU A  77
None
None
None
None
SAM  A 601 (-3.6A)
1.38A 4fglA-5dpdA:
undetectable
4fglB-5dpdA:
undetectable
4fglA-5dpdA:
18.17
4fglB-5dpdA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
6 / 12 GLY A  79
LEU A 103
SER A 104
HIS A 146
VAL A 148
VAL A 152
SAM  A 601 (-3.8A)
SAM  A 601 (-4.2A)
SAM  A 601 (-4.9A)
SAM  A 601 (-3.8A)
None
None
1.18A 4htfA-5dpdA:
15.7
4htfA-5dpdA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
6 / 12 GLY A  79
LEU A 103
SER A 104
HIS A 146
VAL A 148
VAL A 152
SAM  A 601 (-3.8A)
SAM  A 601 (-4.2A)
SAM  A 601 (-4.9A)
SAM  A 601 (-3.8A)
None
None
1.18A 4htfB-5dpdA:
15.8
4htfB-5dpdA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
5 / 12 LEU A  56
LEU A  59
LEU A  62
MET A 285
CYH A 325
None
1.17A 4ltwA-5dpdA:
undetectable
4ltwA-5dpdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 8 ILE A 335
PHE A 343
GLY A  64
ILE A 331
None
0.92A 4qogA-5dpdA:
undetectable
4qogB-5dpdA:
2.4
4qogA-5dpdA:
18.05
4qogB-5dpdA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 5 ILE A  87
VAL A 115
CYH A  80
HIS A  89
None
1.01A 4rzvA-5dpdA:
2.2
4rzvA-5dpdA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 5 ILE A  87
VAL A 115
CYH A  80
HIS A 478
None
1.32A 4rzvA-5dpdA:
2.2
4rzvA-5dpdA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 6 LEU A 508
ILE A 507
LEU A 535
GLU A 536
None
0.82A 4w5nA-5dpdA:
undetectable
4w5nA-5dpdA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
4 / 7 ILE A 143
PHE A 140
VAL A 163
ILE A 133
None
0.94A 4zzbC-5dpdA:
2.0
4zzbD-5dpdA:
2.0
4zzbC-5dpdA:
19.93
4zzbD-5dpdA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
12 / 12 TYR A  48
GLU A  77
GLY A  79
LEU A 103
SER A 104
GLN A 107
SER A 129
ILE A 130
HIS A 146
VAL A 148
VAL A 152
VAL A 156
None
SAM  A 601 (-3.6A)
SAM  A 601 (-3.8A)
SAM  A 601 (-4.2A)
SAM  A 601 (-4.9A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.7A)
SAM  A 601 (-3.9A)
SAM  A 601 (-3.8A)
None
None
SAM  A 601 (-4.6A)
0.00A 5dpdA-5dpdA:
61.8
5dpdA-5dpdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
7 / 12 TYR A  48
GLU A  77
ILE A 160
HIS A 146
VAL A 148
VAL A 152
VAL A 156
None
SAM  A 601 (-3.6A)
None
SAM  A 601 (-3.8A)
None
None
SAM  A 601 (-4.6A)
1.49A 5dpdA-5dpdA:
61.8
5dpdA-5dpdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
6 / 12 GLY A  79
ASP A 102
LEU A 103
SER A 104
GLN A 107
VAL A 152
SAM  A 601 (-3.8A)
SAM  A 601 (-2.4A)
SAM  A 601 (-4.2A)
SAM  A 601 (-4.9A)
SAM  A 601 (-4.6A)
None
1.23A 5dpdB-5dpdA:
57.9
5dpdB-5dpdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
5 / 12 LEU A 103
SER A 104
SER A 129
ILE A 130
VAL A 148
SAM  A 601 (-4.2A)
SAM  A 601 (-4.9A)
SAM  A 601 (-3.7A)
SAM  A 601 (-3.9A)
None
1.04A 5dpdB-5dpdA:
57.9
5dpdB-5dpdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
12 / 12 TYR A  48
GLY A  79
ASP A 102
LEU A 103
SER A 104
GLN A 107
SER A 129
ILE A 130
VAL A 148
TRP A 151
VAL A 152
VAL A 156
None
SAM  A 601 (-3.8A)
SAM  A 601 (-2.4A)
SAM  A 601 (-4.2A)
SAM  A 601 (-4.9A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.7A)
SAM  A 601 (-3.9A)
None
None
None
SAM  A 601 (-4.6A)
0.33A 5dpdB-5dpdA:
57.9
5dpdB-5dpdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
6 / 12 TYR A  48
ILE A 160
VAL A 148
TRP A 151
VAL A 152
VAL A 156
None
None
None
None
None
SAM  A 601 (-4.6A)
1.46A 5dpdB-5dpdA:
57.9
5dpdB-5dpdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
3 / 3 CYH A 164
LYS A 162
HIS A 272
None
0.95A 5js5A-5dpdA:
undetectable
5js5A-5dpdA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii)
5 / 12 LEU A  56
LEU A  59
ALA A  60
LEU A 277
ILE A 144
None
1.04A 5toaA-5dpdA:
undetectable
5toaA-5dpdA:
20.15