SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UDU_A_CIAA1003_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	5dpt	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1, GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1,GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1 (Homo sapiens)	5 / 11	ILE A 39 VAL A 114 ALA A 115 PHE A 85 LEU A 83	None	1.18A	1uduA-5dptA: undetectable	1uduA-5dptA: 16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_B_SAMB602_1 (HYPOTHETICAL PROTEIN)	5dpt	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1, GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1,GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1 (Homo sapiens)	3 / 3	GLU A 24 ASP A 109 TYR A 113	None	0.78A	2yvlB-5dptA: undetectable	2yvlB-5dptA: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RET_A_DGXA1107_2 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	5dpt	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1, GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1,GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1 (Homo sapiens)	4 / 4	ASN A 105 VAL A 64 THR A 90 ILE A 91	None	1.37A	4retA-5dptA: undetectable	4retA-5dptA: 9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RET_C_DGXC2005_2 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	5dpt	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1, GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1,GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1 (Homo sapiens)	4 / 4	ASN A 105 VAL A 64 THR A 90 ILE A 91	None	1.37A	4retC-5dptA: undetectable	4retC-5dptA: 9.15

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UDU_A_CIAA1003_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","5dpt","PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1, GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1,GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1","Homo sapiens",5,"ILE A  39;VAL A 114;ALA A 115;PHE A  85;LEU A  83","None","1.18A","1uduA-5dptA:undetectable","1uduA-5dptA:16.41"],["2YVL_B_SAMB602_1","HYPOTHETICAL PROTEIN","5dpt","PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1, GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1,GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1","Homo sapiens",3,"GLU A  24;ASP A 109;TYR A 113","None","0.78A","2yvlB-5dptA:undetectable","2yvlB-5dptA:20.82"],["4RET_A_DGXA1107_2","SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1","5dpt","PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1, GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1,GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1","Homo sapiens",4,"ASN A 105;VAL A  64;THR A  90;ILE A  91","None","1.37A","4retA-5dptA:undetectable","4retA-5dptA:9.15"],["4RET_C_DGXC2005_2","SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1","5dpt","PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1, GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1,GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1","Homo sapiens",4,"ASN A 105;VAL A  64;THR A  90;ILE A  91","None","1.37A","4retC-5dptA:undetectable","4retC-5dptA:9.15"]]