SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU A 275
LEU A 303
ILE A 210
LEU A 236
PRO A 235
 None
 1.19A 1hrkA-5dq6A:
undetectable		 1hrkA-5dq6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU A 122
LEU A 126
LEU A 104
ILE A 248
ILE A  37
 None
 1.18A 1tw4B-5dq6A:
undetectable		 1tw4B-5dq6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU A 275
LEU A 303
ILE A 210
LEU A 236
PRO A 235
 None
 1.18A 2hrcA-5dq6A:
undetectable		 2hrcA-5dq6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU A 275
LEU A 303
ILE A 210
LEU A 236
PRO A 235
 None
 1.20A 2hrcB-5dq6A:
undetectable		 2hrcB-5dq6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU A 275
LEU A 303
ILE A 210
LEU A 236
PRO A 235
 None
 1.22A 2po7A-5dq6A:
undetectable		 2po7A-5dq6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3
(Mus
musculus) 		5 / 12 LEU A 275
LEU A 303
ILE A 210
LEU A 236
PRO A 235
 None
 1.19A 2po7B-5dq6A:
undetectable		 2po7B-5dq6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3
(Mus
musculus) 		4 / 6 LEU A 236
LEU A 302
GLU A 305
TYR A 306
 None
 1.18A 4f3tA-5dq6A:
undetectable		 4f3tA-5dq6A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3
(Mus
musculus) 		3 / 3 LEU A 270
ARG A 271
ARG A  90
 None
 0.76A 4yiaB-5dq6A:
undetectable		 4yiaB-5dq6A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3
(Mus
musculus) 		5 / 12 ILE A  37
ILE A  29
ILE A 207
ALA A 108
LEU A 104
 None
 0.91A 5e72A-5dq6A:
undetectable		 5e72A-5dq6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3
(Mus
musculus) 		3 / 3 LYS A 228
LYS A 148
SER A 149
 None
 0.96A 5odiA-5dq6A:
undetectable		 5odiA-5dq6A:
20.67