SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dq9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		5 / 12 SER A 108
LEU A  78
TYR A  59
VAL A  48
ALA A  49
 None
 1.25A 2kceA-5dq9A:
undetectable		 2kceA-5dq9A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR A  87
GLU A 148
HIS A 199
 None
 0.57A 3g1uB-5dq9A:
undetectable		 3g1uB-5dq9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		4 / 5 ARG A  94
LEU A   4
VAL A   2
ASP A 101
 None
 0.99A 3ufnA-5dq9A:
undetectable
3ufnB-5dq9A:
undetectable		 3ufnA-5dq9A:
18.02
3ufnB-5dq9A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		5 / 12 GLY A  53
GLY A  54
ASN A  76
GLY A  24
LEU A   4
 KD2  A 301 (-3.6A)
KD2  A 301 (-4.2A)
None
None
None
 0.96A 4fp9A-5dq9A:
undetectable		 4fp9A-5dq9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		5 / 12 GLY A  53
GLY A  54
ASN A  76
GLY A  24
LEU A   4
 KD2  A 301 (-3.6A)
KD2  A 301 (-4.2A)
None
None
None
 0.94A 4fp9C-5dq9A:
undetectable		 4fp9C-5dq9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		5 / 12 GLY A  53
GLY A  54
ASN A  76
GLY A  24
LEU A   4
 KD2  A 301 (-3.6A)
KD2  A 301 (-4.2A)
None
None
None
 0.97A 4fp9D-5dq9A:
undetectable		 4fp9D-5dq9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		5 / 12 GLY A  53
GLY A  54
ASN A  76
GLY A  24
LEU A   4
 KD2  A 301 (-3.6A)
KD2  A 301 (-4.2A)
None
None
None
 0.98A 4fp9F-5dq9A:
undetectable		 4fp9F-5dq9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		5 / 12 GLY A  53
GLY A  54
ASN A  76
GLY A  24
LEU A   4
 KD2  A 301 (-3.6A)
KD2  A 301 (-4.2A)
None
None
None
 0.98A 4fzvA-5dq9A:
undetectable		 4fzvA-5dq9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR A  28
SER A  30
TYR A  32
 None
 0.82A 5jsdA-5dq9A:
2.8		 5jsdA-5dq9A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR A  28
SER A  30
TYR A  32
 None
 0.83A 5jsdB-5dq9A:
undetectable		 5jsdB-5dq9A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR A  28
SER A  30
TYR A  32
 None
 0.82A 5jsdC-5dq9A:
undetectable		 5jsdC-5dq9A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR A  28
SER A  30
TYR A  32
 None
 0.82A 5jseA-5dq9A:
2.6		 5jseA-5dq9A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR A  28
SER A  30
TYR A  32
 None
 0.84A 5jseB-5dq9A:
2.9		 5jseB-5dq9A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR A  28
SER A  30
TYR A  32
 None
 0.84A 5jseC-5dq9A:
2.9		 5jseC-5dq9A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		3 / 3 VAL A 183
SER A 185
TRP A 188
 None
 0.99A 5jwaA-5dq9A:
undetectable		 5jwaA-5dq9A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		5 / 12 GLY A  26
ASP A 101
VAL A   5
ALA A  23
LEU A   4
 None
 1.07A 5kocA-5dq9A:
undetectable		 5kocA-5dq9A:
19.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN
(Mus
musculus) 		4 / 5 SER A 112
ALA A 114
PHE A 146
LEU A 170
 None
 0.36A 5mthA-5dq9A:
25.8		 5mthA-5dq9A:
65.32