SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dql'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.01A 1t85A-5dqlA:
undetectable		 1t85A-5dqlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.00A 1t87A-5dqlA:
undetectable		 1t87A-5dqlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.02A 1yrcA-5dqlA:
undetectable		 1yrcA-5dqlA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 0.99A 1yrdA-5dqlA:
undetectable		 1yrdA-5dqlA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		5 / 11 THR A  27
THR A 210
THR A 208
ALA A 212
ALA A 279
 None
None
None
None
MG  A 502 (-4.8A)
 1.20A 2f162-5dqlA:
undetectable		 2f162-5dqlA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		5 / 11 THR A  27
THR A 210
THR A 208
ALA A 212
ALA A 279
 None
None
None
None
MG  A 502 (-4.8A)
 1.20A 2f16N-5dqlA:
undetectable		 2f16N-5dqlA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.00A 2feuB-5dqlA:
undetectable		 2feuB-5dqlA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 6 PRO A 201
LEU A 185
ARG A 207
GLY A 160
 None
 1.14A 2hs2B-5dqlA:
undetectable		 2hs2B-5dqlA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 0.99A 2zwtA-5dqlA:
undetectable		 2zwtA-5dqlA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.01A 2zwuA-5dqlA:
undetectable		 2zwuA-5dqlA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 283
GLU A 285
ASP A 230
SER A 315
 None
None
None
VGX  A 503 (-2.5A)
 1.48A 3dzgA-5dqlA:
undetectable		 3dzgA-5dqlA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 283
ASP A 230
SER A 315
THR A 347
 None
None
VGX  A 503 (-2.5A)
VGX  A 503 (-3.0A)
 1.10A 3dzgB-5dqlA:
undetectable		 3dzgB-5dqlA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 283
GLU A 285
ASP A 230
SER A 315
 None
None
None
VGX  A 503 (-2.5A)
 1.40A 3dzgB-5dqlA:
undetectable		 3dzgB-5dqlA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.02A 3fwfA-5dqlA:
undetectable		 3fwfA-5dqlA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.01A 3fwfB-5dqlA:
undetectable		 3fwfB-5dqlA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.02A 3fwjA-5dqlA:
undetectable		 3fwjA-5dqlA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.00A 3l63A-5dqlA:
undetectable		 3l63A-5dqlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		5 / 12 THR A  27
THR A 210
THR A 208
ALA A 212
ALA A 279
 None
None
None
None
MG  A 502 (-4.8A)
 1.17A 3mg02-5dqlA:
undetectable
3mg0V-5dqlA:
undetectable		 3mg02-5dqlA:
18.24
3mg0V-5dqlA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		5 / 11 THR A  27
THR A 210
THR A 208
ALA A 212
ALA A 279
 None
None
None
None
MG  A 502 (-4.8A)
 1.16A 3mg0N-5dqlA:
undetectable		 3mg0N-5dqlA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.01A 3wrhA-5dqlA:
undetectable		 3wrhA-5dqlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.01A 3wrjA-5dqlA:
undetectable		 3wrjA-5dqlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.00A 3wrlA-5dqlA:
undetectable		 3wrlA-5dqlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.01A 3wrlE-5dqlA:
undetectable		 3wrlE-5dqlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.01A 3wrmA-5dqlA:
undetectable		 3wrmA-5dqlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.00A 3wrmF-5dqlA:
undetectable		 3wrmF-5dqlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 1.00A 4l4gA-5dqlA:
undetectable		 4l4gA-5dqlA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		5 / 12 THR A  27
THR A 210
THR A 208
ALA A 212
ALA A 279
 None
None
None
None
MG  A 502 (-4.8A)
 1.18A 4qvnV-5dqlA:
undetectable
4qvnb-5dqlA:
undetectable		 4qvnV-5dqlA:
20.57
4qvnb-5dqlA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		5 / 12 THR A  27
THR A 210
THR A 208
ALA A 212
ALA A 279
 None
None
None
None
MG  A 502 (-4.8A)
 1.18A 4qvnH-5dqlA:
undetectable
4qvnN-5dqlA:
undetectable		 4qvnH-5dqlA:
20.57
4qvnN-5dqlA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 150
VAL A  78
VAL A  81
LEU A  90
THR A  73
 None
 1.06A 5bykA-5dqlA:
undetectable		 5bykA-5dqlA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		5 / 12 THR A  27
THR A 210
THR A 208
ALA A 212
ALA A 279
 None
None
None
None
MG  A 502 (-4.8A)
 1.20A 5lf7H-5dqlA:
undetectable
5lf7N-5dqlA:
undetectable		 5lf7H-5dqlA:
20.90
5lf7N-5dqlA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 7 THR A 389
VAL A  78
VAL A 143
ASP A 140
 None
 0.96A 5wk9A-5dqlA:
undetectable		 5wk9A-5dqlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 150
VAL A  78
VAL A  81
LEU A  90
THR A  73
 None
 1.12A 6b52A-5dqlA:
undetectable		 6b52A-5dqlA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 6 GLN A 333
GLU A 335
ALA A 337
GLN A 344
 None
 1.13A 6f6jC-5dqlA:
undetectable
6f6jD-5dqlA:
undetectable		 6f6jC-5dqlA:
25.33
6f6jD-5dqlA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		5 / 12 THR A  27
THR A 210
THR A 208
ALA A 212
ALA A 279
 None
None
None
None
MG  A 502 (-4.8A)
 1.19A 6hwdV-5dqlA:
undetectable
6hwdb-5dqlA:
undetectable		 6hwdV-5dqlA:
11.96
6hwdb-5dqlA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		5 / 12 THR A  27
THR A 210
THR A 208
ALA A 212
ALA A 279
 None
None
None
None
MG  A 502 (-4.8A)
 1.19A 6hwdH-5dqlA:
undetectable
6hwdN-5dqlA:
undetectable		 6hwdH-5dqlA:
11.96
6hwdN-5dqlA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 4 ASP A 230
ILE A 200
PRO A 201
LEU A 199
 None
 1.14A 6mkeB-5dqlA:
undetectable		 6mkeB-5dqlA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5dql ISOCITRATE LYASE 1
(Mycobacterium
tuberculosis) 		4 / 4 ASP A 230
ILE A 200
PRO A 201
LEU A 199
 None
 1.06A 6mkeA-5dqlA:
undetectable		 6mkeA-5dqlA:
9.68