SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5dqs ELONGATION FACTOR
1-GAMMA
(Homo
sapiens) 		4 / 7 ILE A  75
PHE A  53
PHE A  49
PHE A  40
 None
 0.98A 1e71M-5dqsA:
undetectable		 1e71M-5dqsA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5dqs ELONGATION FACTOR
1-GAMMA
(Homo
sapiens) 		4 / 7 ILE A  75
PHE A  53
PHE A  49
PHE A  40
 None
 0.98A 1e72M-5dqsA:
undetectable		 1e72M-5dqsA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 5dqs ELONGATION FACTOR
1-GAMMA
(Homo
sapiens) 		3 / 3 ASN A  12
PHE A  40
VAL A  58
 None
 0.75A 1kijA-5dqsA:
undetectable		 1kijA-5dqsA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5dqs ELONGATION FACTOR
1-BETA
(Homo
sapiens) 		4 / 8 SER D  61
TYR D  62
TYR D  24
HIS D  58
 None
 1.33A 2bteD-5dqsD:
undetectable		 2bteD-5dqsD:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 5dqs ELONGATION FACTOR
1-BETA
(Homo
sapiens) 		5 / 12 LEU D  12
GLY D   2
LYS D  74
VAL D  37
ALA D  40
 None
 1.33A 2kceA-5dqsD:
undetectable		 2kceA-5dqsD:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5dqs ELONGATION FACTOR
1-GAMMA
(Homo
sapiens) 		5 / 12 LEU A 139
LEU A 146
ASP A 105
LEU A 168
LEU A 171
 None
 1.11A 2zbpA-5dqsA:
undetectable		 2zbpA-5dqsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5dqs ELONGATION FACTOR
1-GAMMA
(Homo
sapiens) 		5 / 12 LEU A 139
LEU A 146
ASP A 105
LEU A 168
LEU A 171
 None
 1.10A 3cjtK-5dqsA:
undetectable		 3cjtK-5dqsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5dqs ELONGATION FACTOR
1-GAMMA
ELONGATION FACTOR
1-BETA
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN A 186
ASP D  17
GLN D  13
 None
 0.82A 3eeyC-5dqsA:
undetectable		 3eeyC-5dqsA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5dqs ELONGATION FACTOR
1-GAMMA
ELONGATION FACTOR
1-BETA
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN A 186
ASP D  17
GLN D  13
 None
 0.81A 3eeyD-5dqsA:
undetectable		 3eeyD-5dqsA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5dqs ELONGATION FACTOR
1-GAMMA
ELONGATION FACTOR
1-BETA
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN A 186
ASP D  17
GLN D  13
 None
 0.82A 3eeyE-5dqsA:
undetectable		 3eeyE-5dqsA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 5dqs ELONGATION FACTOR
1-GAMMA
(Homo
sapiens) 		5 / 12 LEU A   6
GLN A  28
ALA A   2
ASP A  65
ASP A  64
 None
 1.00A 3gwuA-5dqsA:
undetectable		 3gwuA-5dqsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5dqs ELONGATION FACTOR
1-BETA
(Homo
sapiens) 		5 / 12 GLY D  80
GLY D   4
ASP D   5
LEU D   6
ALA D  33
 None
 1.12A 3ou6A-5dqsD:
undetectable		 3ou6A-5dqsD:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5dqs ELONGATION FACTOR
1-GAMMA
(Homo
sapiens) 		4 / 4 ALA A 160
VAL A 164
ASP A 161
LEU A 146
 None
 1.03A 4e7gA-5dqsA:
undetectable		 4e7gA-5dqsA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5dqs ELONGATION FACTOR
1-BETA
(Homo
sapiens) 		5 / 12 GLY D   2
GLY D  77
LEU D   6
LEU D  76
ALA D  82
 None
 1.14A 4lg1B-5dqsD:
undetectable		 4lg1B-5dqsD:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5dqs ELONGATION FACTOR
1-BETA
(Homo
sapiens) 		5 / 12 GLY D   2
GLY D  77
LEU D   6
LEU D  76
ALA D  82
 None
 1.15A 4lg1C-5dqsD:
undetectable		 4lg1C-5dqsD:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 5dqs ELONGATION FACTOR
1-GAMMA
(Homo
sapiens) 		4 / 6 ASP A 143
PRO A 178
TYR A 172
LEU A 209
 None
 1.10A 5bmvB-5dqsA:
undetectable		 5bmvB-5dqsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5dqs ELONGATION FACTOR
1-GAMMA
(Homo
sapiens) 		4 / 8 GLY A  66
ARG A  30
GLN A  28
ASP A  64
 None
 1.02A 5vlmA-5dqsA:
undetectable		 5vlmA-5dqsA:
24.12