SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5drz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 5drz HIV ANTIBODY F240
HEAVY CHAIN
(Homo
sapiens) 		4 / 8 GLN H   6
VAL H 109
GLY H   8
GLY H   9
 None
 0.72A 1ekjE-5drzH:
undetectable
1ekjF-5drzH:
undetectable		 1ekjE-5drzH:
22.04
1ekjF-5drzH:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 5drz HIV ANTIBODY F240
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.82A 1ictD-5drzL:
undetectable		 1ictD-5drzL:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5drz HIV ANTIBODY F240
HEAVY CHAIN
(Homo
sapiens) 		4 / 5 GLY H 190
GLN H 192
VAL H 184
SER H 187
 None
 1.41A 1zzuB-5drzH:
undetectable		 1zzuB-5drzH:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5drz HIV ANTIBODY F240
LIGHT CHAIN
(Homo
sapiens) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.83A 2aojA-5drzL:
undetectable		 2aojA-5drzL:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5drz HIV ANTIBODY F240
HEAVY CHAIN
HIV ANTIBODY F240
LIGHT CHAIN
(Homo
sapiens) 		5 / 12 PHE H 100
ARG H  38
ILE H  37
SER H  35
PHE L  98
 None
 1.42A 2vdyB-5drzH:
undetectable		 2vdyB-5drzH:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5drz HIV ANTIBODY F240
HEAVY CHAIN
(Homo
sapiens) 		4 / 5 PRO H 119
THR H 110
VAL H  11
GLY H  10
 None
 1.12A 3elzA-5drzH:
undetectable		 3elzA-5drzH:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5drz HIV ANTIBODY F240
LIGHT CHAIN
(Homo
sapiens) 		3 / 3 PHE L  71
TYR L  92
LEU L  47
 None
 0.71A 3keeB-5drzL:
undetectable		 3keeB-5drzL:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 5drz HIV ANTIBODY F240
LIGHT CHAIN
(Homo
sapiens) 		4 / 4 PHE L  71
TYR L  92
VAL L  55
LEU L  47
 None
 1.17A 3keeD-5drzL:
undetectable		 3keeD-5drzL:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5drz HIV ANTIBODY F240
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H   2
MET H  34
ARG H  71
ASN H  73
VAL H  78
 None
 0.55A 3qxvA-5drzH:
18.8		 3qxvA-5drzH:
55.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5drz HIV ANTIBODY F240
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL H   2
MET H  34
ARG H  71
ASN H  73
VAL H  78
 None
 0.56A 3qxvC-5drzH:
18.9		 3qxvC-5drzH:
55.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5drz HIV ANTIBODY F240
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 LYS H  43
ARG H 108
VAL H 109
 None
 0.90A 4x3uA-5drzH:
undetectable
4x3uB-5drzH:
undetectable		 4x3uA-5drzH:
9.87
4x3uB-5drzH:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5drz HIV ANTIBODY F240
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 GLY H  54
PHE H  29
THR H  28
TYR H  33
VAL H  78
 None
 1.26A 5d0yA-5drzH:
undetectable		 5d0yA-5drzH:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5drz HIV ANTIBODY F240
LIGHT CHAIN
(Homo
sapiens) 		4 / 5 THR L  94
THR L  93
TYR L  92
HIS L  95
 None
 1.36A 5ecmA-5drzL:
undetectable		 5ecmA-5drzL:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5drz HIV ANTIBODY F240
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.07A 6drzA-5drzH:
undetectable		 6drzA-5drzH:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5drz HIV ANTIBODY F240
LIGHT CHAIN
(Homo
sapiens) 		4 / 5 ARG L  39
ALA L  83
GLN L  37
ILE L  75
 None
MG  L 301 (-3.3A)
None
None
 1.35A 6f6sA-5drzL:
undetectable
6f6sB-5drzL:
undetectable		 6f6sA-5drzL:
15.00
6f6sB-5drzL:
16.98