SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ds0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CMA_A_SAMA105_0 (PROTEIN (MET REPRESSOR))	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 8	GLU A 190 ARG A 193 ARG A 194 GLU A 337	None	0.77A	1cmaA-5ds0A: undetectable 1cmaB-5ds0A: undetectable	1cmaA-5ds0A: 16.06 1cmaB-5ds0A: 16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_D_THAD4_2 (LIVER CARBOXYLESTERASE I)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	3 / 3	PHE A 278 LEU A 350 MET A 63	None	0.64A	1mx1D-5ds0A: 2.9	1mx1D-5ds0A: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXD_A_ACRA732_1 (ALPHA AMYLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 9	GLY A 90 PRO A 161 GLU A 69 GLY A 71 ASP A 180	None None None None CO A 401 ( 2.3A)	0.88A	1mxdA-5ds0A: undetectable	1mxdA-5ds0A: 23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXG_A_ACRA442_1 (ALPHA AMYLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 11	GLY A 90 PRO A 161 GLU A 69 GLY A 71 ASP A 180	None None None None CO A 401 ( 2.3A)	0.87A	1mxgA-5ds0A: undetectable	1mxgA-5ds0A: 23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V7Z_A_CRNA401_1 (CREATININE AMIDOHYDROLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 8	GLU A 237 HIS A 66 ASP A 180 GLU A 215	CO A 402 (-2.0A) CO A 402 (-3.2A) CO A 401 ( 2.3A) CO A 401 (-2.0A)	0.88A	1v7zA-5ds0A: 4.6	1v7zA-5ds0A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V7Z_B_CRNB3401_1 (CREATININE AMIDOHYDROLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 8	GLU A 237 HIS A 66 ASP A 180 GLU A 215	CO A 402 (-2.0A) CO A 402 (-3.2A) CO A 401 ( 2.3A) CO A 401 (-2.0A)	0.88A	1v7zB-5ds0A: 4.6	1v7zB-5ds0A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V7Z_C_CRNC4401_1 (CREATININE AMIDOHYDROLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 8	GLU A 237 HIS A 66 ASP A 180 GLU A 215	CO A 402 (-2.0A) CO A 402 (-3.2A) CO A 401 ( 2.3A) CO A 401 (-2.0A)	0.89A	1v7zC-5ds0A: 4.6	1v7zC-5ds0A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V7Z_D_CRND5401_1 (CREATININE AMIDOHYDROLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 8	GLU A 237 HIS A 66 ASP A 180 GLU A 215	CO A 402 (-2.0A) CO A 402 (-3.2A) CO A 401 ( 2.3A) CO A 401 (-2.0A)	0.88A	1v7zD-5ds0A: 4.6	1v7zD-5ds0A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V7Z_E_CRNE6401_1 (CREATININE AMIDOHYDROLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 8	GLU A 237 HIS A 66 ASP A 180 GLU A 215	CO A 402 (-2.0A) CO A 402 (-3.2A) CO A 401 ( 2.3A) CO A 401 (-2.0A)	0.88A	1v7zE-5ds0A: 4.6	1v7zE-5ds0A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V7Z_F_CRNF7401_1 (CREATININE AMIDOHYDROLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 8	GLU A 237 HIS A 66 ASP A 180 GLU A 215	CO A 402 (-2.0A) CO A 402 (-3.2A) CO A 401 ( 2.3A) CO A 401 (-2.0A)	0.89A	1v7zF-5ds0A: 4.6	1v7zF-5ds0A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXE_A_1FLA2003_1 (SERUM ALBUMIN)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 9	LEU A 346 ARG A 349 LEU A 342 LEU A 290 ALA A 286	None	1.24A	2bxeA-5ds0A: undetectable	2bxeA-5ds0A: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QMJ_A_ACRA1001_1 (MALTASE-GLUCOAMYLASE , INTESTINAL)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 12	ASP A 266 ASP A 180 ILE A 324 ALA A 64 HIS A 66	None CO A 401 ( 2.3A) None None CO A 402 (-3.2A)	1.35A	2qmjA-5ds0A: undetectable	2qmjA-5ds0A: 18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XIN_A_SORA397_0 (D-XYLOSE ISOMERASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 12	THR A 321 GLU A 237 GLU A 214 HIS A 66 ASP A 68	None CO A 402 (-2.0A) CO A 402 (-3.4A) CO A 402 (-3.2A) None	1.48A	2xinA-5ds0A: undetectable	2xinA-5ds0A: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A6J_A_CRNA303_1 (CREATININE AMIDOHYDROLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 8	GLU A 237 HIS A 66 ASP A 180 GLU A 215	CO A 402 (-2.0A) CO A 402 (-3.2A) CO A 401 ( 2.3A) CO A 401 (-2.0A)	0.92A	3a6jA-5ds0A: 4.6	3a6jA-5ds0A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A6J_B_CRNB304_1 (CREATININE AMIDOHYDROLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 7	GLU A 237 HIS A 66 ASP A 180 GLU A 215	CO A 402 (-2.0A) CO A 402 (-3.2A) CO A 401 ( 2.3A) CO A 401 (-2.0A)	0.92A	3a6jB-5ds0A: 4.6	3a6jB-5ds0A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A6J_C_CRNC305_1 (CREATININE AMIDOHYDROLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 8	GLU A 237 HIS A 66 ASP A 180 GLU A 215	CO A 402 (-2.0A) CO A 402 (-3.2A) CO A 401 ( 2.3A) CO A 401 (-2.0A)	0.92A	3a6jC-5ds0A: 4.5	3a6jC-5ds0A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A6J_E_CRNE306_1 (CREATININE AMIDOHYDROLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 8	GLU A 237 HIS A 66 ASP A 180 GLU A 215	CO A 402 (-2.0A) CO A 402 (-3.2A) CO A 401 ( 2.3A) CO A 401 (-2.0A)	0.93A	3a6jE-5ds0A: 4.4	3a6jE-5ds0A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A6J_F_CRNF307_1 (CREATININE AMIDOHYDROLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 8	GLU A 237 HIS A 66 ASP A 180 GLU A 215	CO A 402 (-2.0A) CO A 402 (-3.2A) CO A 401 ( 2.3A) CO A 401 (-2.0A)	0.92A	3a6jF-5ds0A: 4.5	3a6jF-5ds0A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ADS_A_IMNA1_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 10	GLU A 69 GLY A 176 LEU A 333 ILE A 183 MET A 7	None	1.34A	3adsA-5ds0A: undetectable	3adsA-5ds0A: 23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B9M_A_SALA1100_1 (SERUM ALBUMIN)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 4	LEU A 290 ARG A 349 LEU A 346 ALA A 286	None	1.02A	3b9mA-5ds0A: undetectable	3b9mA-5ds0A: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CE6_D_ADND500_1 (ADENOSYLHOMOCYSTEINA SE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 12	GLU A 214 THR A 300 ASP A 180 GLY A 90 HIS A 325	CO A 402 (-3.4A) None CO A 401 ( 2.3A) None CO A 401 (-3.3A)	1.33A	3ce6D-5ds0A: undetectable	3ce6D-5ds0A: 23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_A_CHDA200_0 (ILEAL BILE ACID-BINDING PROTEIN)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 5	THR A 105 VAL A 153 GLY A 152 LYS A 107	None	1.17A	3elzA-5ds0A: undetectable	3elzA-5ds0A: 18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ID5_B_SAMB301_0 (FIBRILLARIN-LIKE RRNA/TRNA 2'-O-METHYLTRANSFERA SE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 11	GLY A 208 THR A 211 ASP A 39 ALA A 38 ILE A 192	None	1.39A	3id5B-5ds0A: undetectable	3id5B-5ds0A: 23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ID5_F_SAMF301_0 (FIBRILLARIN-LIKE RRNA/TRNA 2'-O-METHYLTRANSFERA SE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 11	GLY A 208 THR A 211 ASP A 39 ALA A 38 ILE A 192	None	1.39A	3id5F-5ds0A: undetectable	3id5F-5ds0A: 23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3XIM_C_SORC397_0 (D-XYLOSE ISOMERASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 12	THR A 321 GLU A 237 GLU A 214 HIS A 66 ASP A 68	None CO A 402 (-2.0A) CO A 402 (-3.4A) CO A 402 (-3.2A) None	1.43A	3ximC-5ds0A: undetectable	3ximC-5ds0A: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3XIM_D_SORD397_0 (D-XYLOSE ISOMERASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 12	THR A 321 GLU A 237 GLU A 214 HIS A 66 ASP A 68	None CO A 402 (-2.0A) CO A 402 (-3.4A) CO A 402 (-3.2A) None	1.48A	3ximD-5ds0A: undetectable	3ximD-5ds0A: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQF_A_QPSA951_1 (ALPHA-GLUCAN PHOSPHORYLASE 2, CYTOSOLIC)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 6	GLY A 21 ARG A 182 GLU A 25 ARG A 104	None	1.47A	4bqfA-5ds0A: 3.6	4bqfA-5ds0A: 18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVR_A_SALA203_1 (3-HYDROXYANTHRANILAT E 3,4-DIOXYGENASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 7	ASP A 180 GLU A 215 HIS A 325 GLU A 214	CO A 401 ( 2.3A) CO A 401 (-2.0A) CO A 401 (-3.3A) CO A 402 (-3.4A)	0.98A	4hvrA-5ds0A: undetectable	4hvrA-5ds0A: 17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PQA_A_X8ZA401_1 (SUCCINYL-DIAMINOPIME LATE DESUCCINYLASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	9 / 11	HIS A 66 ASP A 180 GLU A 214 GLU A 215 GLU A 237 GLY A 297 GLY A 298 ILE A 324 HIS A 325	CO A 402 (-3.2A) CO A 401 ( 2.3A) CO A 402 (-3.4A) CO A 401 (-2.0A) CO A 402 (-2.0A) None None None CO A 401 (-3.3A)	0.86A	4pqaA-5ds0A: 24.5	4pqaA-5ds0A: 25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QKN_A_JMSA602_1 (ALPHA-KETOGLUTARATE- DEPENDENT DIOXYGENASE FTO)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 8	LEU A 62 LEU A 188 VAL A 49 SER A 48	None	0.89A	4qknA-5ds0A: undetectable	4qknA-5ds0A: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R21_B_STRB601_1 (CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 9	ALA A 221 GLY A 65 ALA A 64 SER A 314 VAL A 316	None	1.07A	4r21B-5ds0A: undetectable	4r21B-5ds0A: 20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 12	LEU A 292 LEU A 342 ALA A 283 GLY A 261 GLY A 259	None	0.96A	4rn6B-5ds0A: undetectable	4rn6B-5ds0A: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UAC_A_ACRA501_2 (CARBOHYDRATE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN, CUT1 FAMILY (TC 3.A.1.1.-))	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 7	GLU A 146 SER A 78 GLU A 80 ASP A 135	None	1.29A	4uacA-5ds0A: undetectable	4uacA-5ds0A: 23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EWZ_B_BEZB301_0 (14-3-3 PROTEIN ZETA/DELTA)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	3 / 3	MET A 195 GLN A 198 ARG A 193	None	0.98A	5ewzB-5ds0A: undetectable	5ewzB-5ds0A: 22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M36_A_BEZA303_0 (14-3-3 PROTEIN ZETA/DELTA)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	3 / 3	MET A 195 GLN A 198 ARG A 193	None	1.08A	5m36A-5ds0A: undetectable	5m36A-5ds0A: 22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X66_A_MTXA402_1 (THYMIDYLATE SYNTHASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 12	PHE A 72 ILE A 114 LEU A 83 PHE A 85 ALA A 142	None	1.10A	5x66A-5ds0A: undetectable 5x66B-5ds0A: undetectable	5x66A-5ds0A: 20.80 5x66B-5ds0A: 20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X66_F_MTXF402_1 (THYMIDYLATE SYNTHASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 12	PHE A 72 ILE A 114 LEU A 83 PHE A 85 ALA A 142	None	1.09A	5x66F-5ds0A: undetectable	5x66F-5ds0A: 20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIM_A_SORA397_0 (D-XYLOSE ISOMERASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 12	THR A 321 GLU A 237 GLU A 214 HIS A 66 ASP A 68	None CO A 402 (-2.0A) CO A 402 (-3.4A) CO A 402 (-3.2A) None	1.46A	5ximA-5ds0A: undetectable	5ximA-5ds0A: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIM_C_SORC397_0 (D-XYLOSE ISOMERASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 12	THR A 321 GLU A 237 GLU A 214 HIS A 66 ASP A 68	None CO A 402 (-2.0A) CO A 402 (-3.4A) CO A 402 (-3.2A) None	1.48A	5ximC-5ds0A: undetectable	5ximC-5ds0A: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIM_D_SORD397_0 (D-XYLOSE ISOMERASE)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	5 / 12	THR A 321 GLU A 237 GLU A 214 HIS A 66 ASP A 68	None CO A 402 (-2.0A) CO A 402 (-3.4A) CO A 402 (-3.2A) None	1.46A	5ximD-5ds0A: undetectable	5ximD-5ds0A: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZRF_D_EVPD101_1 ()	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 5	GLY A 65 ASP A 181 ARG A 182 GLN A 213	None	1.49A	5zrfB-5ds0A: 3.1	5zrfB-5ds0A: 19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F88_B_STRB502_1 (CYTOCHROME P450 CYP260A1)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 6	LEU A 188 ALA A 185 LEU A 62 THR A 224	None	0.89A	6f88B-5ds0A: undetectable	6f88B-5ds0A: 11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA824_0 (GEPHYRIN)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 4	LEU A 352 ASP A 231 PRO A 59 ARG A 58	None	1.44A	6fgdA-5ds0A: 3.3	6fgdA-5ds0A: 24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN5_A_LLLA301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 6	ASP A 44 GLU A 23 ASP A 68 GLU A 214	None None None CO A 402 (-3.4A)	1.06A	6mn5A-5ds0A: undetectable	6mn5A-5ds0A: 11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN5_C_LLLC301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	5ds0	PEPTIDASE M42 (Thaumarchaeota archaeon SCGC AB-539-E09)	4 / 6	ASP A 44 GLU A 23 ASP A 68 GLU A 214	None None None CO A 402 (-3.4A)	1.19A	6mn5C-5ds0A: undetectable	6mn5C-5ds0A: 11.98

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1CMA_A_SAMA105_0","PROTEIN (MET REPRESSOR)","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 190;ARG A 193;ARG A 194;GLU A 337","None","0.77A","1cmaA-5ds0A:undetectable;1cmaB-5ds0A:undetectable","1cmaA-5ds0A:16.06;1cmaB-5ds0A:16.06"],["1MX1_D_THAD4_2","LIVER CARBOXYLESTERASE I","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",3,"PHE A 278;LEU A 350;MET A  63","None","0.64A","1mx1D-5ds0A:2.9","1mx1D-5ds0A:20.82"],["1MXD_A_ACRA732_1","ALPHA AMYLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"GLY A  90;PRO A 161;GLU A  69;GLY A  71;ASP A 180","None;None;None;None; CO A 401 ( 2.3A)","0.88A","1mxdA-5ds0A:undetectable","1mxdA-5ds0A:23.22"],["1MXG_A_ACRA442_1","ALPHA AMYLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"GLY A  90;PRO A 161;GLU A  69;GLY A  71;ASP A 180","None;None;None;None; CO A 401 ( 2.3A)","0.87A","1mxgA-5ds0A:undetectable","1mxgA-5ds0A:23.22"],["1V7Z_A_CRNA401_1","CREATININE AMIDOHYDROLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 237;HIS A  66;ASP A 180;GLU A 215"," CO A 402 (-2.0A); CO A 402 (-3.2A); CO A 401 ( 2.3A); CO A 401 (-2.0A)","0.88A","1v7zA-5ds0A:4.6","1v7zA-5ds0A:22.86"],["1V7Z_B_CRNB3401_1","CREATININE AMIDOHYDROLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 237;HIS A  66;ASP A 180;GLU A 215"," CO A 402 (-2.0A); CO A 402 (-3.2A); CO A 401 ( 2.3A); CO A 401 (-2.0A)","0.88A","1v7zB-5ds0A:4.6","1v7zB-5ds0A:22.86"],["1V7Z_C_CRNC4401_1","CREATININE AMIDOHYDROLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 237;HIS A  66;ASP A 180;GLU A 215"," CO A 402 (-2.0A); CO A 402 (-3.2A); CO A 401 ( 2.3A); CO A 401 (-2.0A)","0.89A","1v7zC-5ds0A:4.6","1v7zC-5ds0A:22.86"],["1V7Z_D_CRND5401_1","CREATININE AMIDOHYDROLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 237;HIS A  66;ASP A 180;GLU A 215"," CO A 402 (-2.0A); CO A 402 (-3.2A); CO A 401 ( 2.3A); CO A 401 (-2.0A)","0.88A","1v7zD-5ds0A:4.6","1v7zD-5ds0A:22.86"],["1V7Z_E_CRNE6401_1","CREATININE AMIDOHYDROLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 237;HIS A  66;ASP A 180;GLU A 215"," CO A 402 (-2.0A); CO A 402 (-3.2A); CO A 401 ( 2.3A); CO A 401 (-2.0A)","0.88A","1v7zE-5ds0A:4.6","1v7zE-5ds0A:22.86"],["1V7Z_F_CRNF7401_1","CREATININE AMIDOHYDROLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 237;HIS A  66;ASP A 180;GLU A 215"," CO A 402 (-2.0A); CO A 402 (-3.2A); CO A 401 ( 2.3A); CO A 401 (-2.0A)","0.89A","1v7zF-5ds0A:4.6","1v7zF-5ds0A:22.86"],["2BXE_A_1FLA2003_1","SERUM ALBUMIN","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"LEU A 346;ARG A 349;LEU A 342;LEU A 290;ALA A 286","None","1.24A","2bxeA-5ds0A:undetectable","2bxeA-5ds0A:21.40"],["2QMJ_A_ACRA1001_1","MALTASE-GLUCOAMYLASE, INTESTINAL","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"ASP A 266;ASP A 180;ILE A 324;ALA A  64;HIS A  66","None; CO A 401 ( 2.3A);None;None; CO A 402 (-3.2A)","1.35A","2qmjA-5ds0A:undetectable","2qmjA-5ds0A:18.00"],["2XIN_A_SORA397_0","D-XYLOSE ISOMERASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"THR A 321;GLU A 237;GLU A 214;HIS A  66;ASP A  68","None; CO A 402 (-2.0A); CO A 402 (-3.4A); CO A 402 (-3.2A);None","1.48A","2xinA-5ds0A:undetectable","2xinA-5ds0A:21.84"],["3A6J_A_CRNA303_1","CREATININE AMIDOHYDROLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 237;HIS A  66;ASP A 180;GLU A 215"," CO A 402 (-2.0A); CO A 402 (-3.2A); CO A 401 ( 2.3A); CO A 401 (-2.0A)","0.92A","3a6jA-5ds0A:4.6","3a6jA-5ds0A:22.86"],["3A6J_B_CRNB304_1","CREATININE AMIDOHYDROLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 237;HIS A  66;ASP A 180;GLU A 215"," CO A 402 (-2.0A); CO A 402 (-3.2A); CO A 401 ( 2.3A); CO A 401 (-2.0A)","0.92A","3a6jB-5ds0A:4.6","3a6jB-5ds0A:22.86"],["3A6J_C_CRNC305_1","CREATININE AMIDOHYDROLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 237;HIS A  66;ASP A 180;GLU A 215"," CO A 402 (-2.0A); CO A 402 (-3.2A); CO A 401 ( 2.3A); CO A 401 (-2.0A)","0.92A","3a6jC-5ds0A:4.5","3a6jC-5ds0A:22.86"],["3A6J_E_CRNE306_1","CREATININE AMIDOHYDROLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 237;HIS A  66;ASP A 180;GLU A 215"," CO A 402 (-2.0A); CO A 402 (-3.2A); CO A 401 ( 2.3A); CO A 401 (-2.0A)","0.93A","3a6jE-5ds0A:4.4","3a6jE-5ds0A:22.86"],["3A6J_F_CRNF307_1","CREATININE AMIDOHYDROLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 237;HIS A  66;ASP A 180;GLU A 215"," CO A 402 (-2.0A); CO A 402 (-3.2A); CO A 401 ( 2.3A); CO A 401 (-2.0A)","0.92A","3a6jF-5ds0A:4.5","3a6jF-5ds0A:22.86"],["3ADS_A_IMNA1_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"GLU A  69;GLY A 176;LEU A 333;ILE A 183;MET A   7","None","1.34A","3adsA-5ds0A:undetectable","3adsA-5ds0A:23.22"],["3B9M_A_SALA1100_1","SERUM ALBUMIN","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"LEU A 290;ARG A 349;LEU A 346;ALA A 286","None","1.02A","3b9mA-5ds0A:undetectable","3b9mA-5ds0A:21.40"],["3CE6_D_ADND500_1","ADENOSYLHOMOCYSTEINASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"GLU A 214;THR A 300;ASP A 180;GLY A  90;HIS A 325"," CO A 402 (-3.4A);None; CO A 401 ( 2.3A);None; CO A 401 (-3.3A)","1.33A","3ce6D-5ds0A:undetectable","3ce6D-5ds0A:23.19"],["3ELZ_A_CHDA200_0","ILEAL BILE ACID-BINDING PROTEIN","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"THR A 105;VAL A 153;GLY A 152;LYS A 107","None","1.17A","3elzA-5ds0A:undetectable","3elzA-5ds0A:18.98"],["3ID5_B_SAMB301_0","FIBRILLARIN-LIKE RRNA\/TRNA 2'-O-METHYLTRANSFERASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"GLY A 208;THR A 211;ASP A  39;ALA A  38;ILE A 192","None","1.39A","3id5B-5ds0A:undetectable","3id5B-5ds0A:23.63"],["3ID5_F_SAMF301_0","FIBRILLARIN-LIKE RRNA\/TRNA 2'-O-METHYLTRANSFERASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"GLY A 208;THR A 211;ASP A  39;ALA A  38;ILE A 192","None","1.39A","3id5F-5ds0A:undetectable","3id5F-5ds0A:23.63"],["3XIM_C_SORC397_0","D-XYLOSE ISOMERASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"THR A 321;GLU A 237;GLU A 214;HIS A  66;ASP A  68","None; CO A 402 (-2.0A); CO A 402 (-3.4A); CO A 402 (-3.2A);None","1.43A","3ximC-5ds0A:undetectable","3ximC-5ds0A:21.41"],["3XIM_D_SORD397_0","D-XYLOSE ISOMERASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"THR A 321;GLU A 237;GLU A 214;HIS A  66;ASP A  68","None; CO A 402 (-2.0A); CO A 402 (-3.4A); CO A 402 (-3.2A);None","1.48A","3ximD-5ds0A:undetectable","3ximD-5ds0A:21.41"],["4BQF_A_QPSA951_1","ALPHA-GLUCAN PHOSPHORYLASE 2, CYTOSOLIC","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLY A  21;ARG A 182;GLU A  25;ARG A 104","None","1.47A","4bqfA-5ds0A:3.6","4bqfA-5ds0A:18.65"],["4HVR_A_SALA203_1","3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"ASP A 180;GLU A 215;HIS A 325;GLU A 214"," CO A 401 ( 2.3A); CO A 401 (-2.0A); CO A 401 (-3.3A); CO A 402 (-3.4A)","0.98A","4hvrA-5ds0A:undetectable","4hvrA-5ds0A:17.27"],["4PQA_A_X8ZA401_1","SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",9,"HIS A  66;ASP A 180;GLU A 214;GLU A 215;GLU A 237;GLY A 297;GLY A 298;ILE A 324;HIS A 325"," CO A 402 (-3.2A); CO A 401 ( 2.3A); CO A 402 (-3.4A); CO A 401 (-2.0A); CO A 402 (-2.0A);None;None;None; CO A 401 (-3.3A)","0.86A","4pqaA-5ds0A:24.5","4pqaA-5ds0A:25.42"],["4QKN_A_JMSA602_1","ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"LEU A  62;LEU A 188;VAL A  49;SER A  48","None","0.89A","4qknA-5ds0A:undetectable","4qknA-5ds0A:20.87"],["4R21_B_STRB601_1","CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"ALA A 221;GLY A  65;ALA A  64;SER A 314;VAL A 316","None","1.07A","4r21B-5ds0A:undetectable","4r21B-5ds0A:20.89"],["4RN6_B_15UB301_1","THROMBIN HEAVY CHAIN","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"LEU A 292;LEU A 342;ALA A 283;GLY A 261;GLY A 259","None","0.96A","4rn6B-5ds0A:undetectable","4rn6B-5ds0A:21.93"],["4UAC_A_ACRA501_2","CARBOHYDRATE ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN, CUT1 FAMILY (TC 3.A.1.1.-)","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLU A 146;SER A  78;GLU A  80;ASP A 135","None","1.29A","4uacA-5ds0A:undetectable","4uacA-5ds0A:23.46"],["5EWZ_B_BEZB301_0","14-3-3 PROTEIN ZETA\/DELTA","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",3,"MET A 195;GLN A 198;ARG A 193","None","0.98A","5ewzB-5ds0A:undetectable","5ewzB-5ds0A:22.35"],["5M36_A_BEZA303_0","14-3-3 PROTEIN ZETA\/DELTA","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",3,"MET A 195;GLN A 198;ARG A 193","None","1.08A","5m36A-5ds0A:undetectable","5m36A-5ds0A:22.54"],["5X66_A_MTXA402_1","THYMIDYLATE SYNTHASE;THYMIDYLATE SYNTHASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"PHE A  72;ILE A 114;LEU A  83;PHE A  85;ALA A 142","None","1.10A","5x66A-5ds0A:undetectable;5x66B-5ds0A:undetectable","5x66A-5ds0A:20.80;5x66B-5ds0A:20.80"],["5X66_F_MTXF402_1","THYMIDYLATE SYNTHASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"PHE A  72;ILE A 114;LEU A  83;PHE A  85;ALA A 142","None","1.09A","5x66F-5ds0A:undetectable","5x66F-5ds0A:20.80"],["5XIM_A_SORA397_0","D-XYLOSE ISOMERASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"THR A 321;GLU A 237;GLU A 214;HIS A  66;ASP A  68","None; CO A 402 (-2.0A); CO A 402 (-3.4A); CO A 402 (-3.2A);None","1.46A","5ximA-5ds0A:undetectable","5ximA-5ds0A:21.84"],["5XIM_C_SORC397_0","D-XYLOSE ISOMERASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"THR A 321;GLU A 237;GLU A 214;HIS A  66;ASP A  68","None; CO A 402 (-2.0A); CO A 402 (-3.4A); CO A 402 (-3.2A);None","1.48A","5ximC-5ds0A:undetectable","5ximC-5ds0A:21.84"],["5XIM_D_SORD397_0","D-XYLOSE ISOMERASE","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",5,"THR A 321;GLU A 237;GLU A 214;HIS A  66;ASP A  68","None; CO A 402 (-2.0A); CO A 402 (-3.4A); CO A 402 (-3.2A);None","1.46A","5ximD-5ds0A:undetectable","5ximD-5ds0A:21.84"],["5ZRF_D_EVPD101_1",";","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"GLY A  65;ASP A 181;ARG A 182;GLN A 213","None","1.49A","5zrfB-5ds0A:3.1","5zrfB-5ds0A:19.95"],["6F88_B_STRB502_1","CYTOCHROME P450 CYP260A1","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"LEU A 188;ALA A 185;LEU A  62;THR A 224","None","0.89A","6f88B-5ds0A:undetectable","6f88B-5ds0A:11.36"],["6FGD_A_ACTA824_0","GEPHYRIN","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"LEU A 352;ASP A 231;PRO A  59;ARG A  58","None","1.44A","6fgdA-5ds0A:3.3","6fgdA-5ds0A:24.02"],["6MN5_A_LLLA301_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"ASP A  44;GLU A  23;ASP A  68;GLU A 214","None;None;None; CO A 402 (-3.4A)","1.06A","6mn5A-5ds0A:undetectable","6mn5A-5ds0A:11.98"],["6MN5_C_LLLC301_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA","5ds0","PEPTIDASE M42","Thaumarchaeota archaeon SCGC AB-539-E09",4,"ASP A  44;GLU A  23;ASP A  68;GLU A 214","None;None;None; CO A 402 (-3.4A)","1.19A","6mn5C-5ds0A:undetectable","6mn5C-5ds0A:11.98"]]