SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HH9_A_VIBA702_1
(THIAMIN
PYROPHOSPHOKINASE)		 5dsc FAB HOU24.B LIGHT
CHAIN
(Oryctolagus
cuniculus) 		5 / 9 TYR B 139
VAL B 195
SER B 176
SER B 161
ASN B 160
 None
 1.31A 2hh9A-5dscB:
0.0
2hh9B-5dscB:
0.0		 2hh9A-5dscB:
19.17
2hh9B-5dscB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HH9_B_VIBB701_1
(THIAMIN
PYROPHOSPHOKINASE)		 5dsc FAB HOU24.B LIGHT
CHAIN
(Oryctolagus
cuniculus) 		5 / 9 VAL B 195
SER B 176
SER B 161
ASN B 160
TYR B 139
 None
 1.30A 2hh9A-5dscB:
0.0
2hh9B-5dscB:
0.0		 2hh9A-5dscB:
19.17
2hh9B-5dscB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5dsc FAB HOU24.B LIGHT
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 GLN B 184
THR B 131
VAL B 130
ILE B 158
GLN B 154
 None
 1.43A 3elzC-5dscB:
undetectable		 3elzC-5dscB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5dsc FAB HOU24.B LIGHT
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 GLN B 154
THR B 153
THR B 152
 None
 0.81A 4fu9A-5dscB:
undetectable		 4fu9A-5dscB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5dsc FAB HOU24.B LIGHT
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 GLN B 154
THR B 153
THR B 152
 None
 0.80A 4fufA-5dscB:
undetectable		 4fufA-5dscB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5dsc FAB HOU24.B LIGHT
CHAIN
(Oryctolagus
cuniculus) 		4 / 4 VAL B 125
VAL B 130
TYR B 185
GLN B 184
 None
 1.28A 5qgpA-5dscB:
undetectable		 5qgpA-5dscB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5dsc FAB HOU24.B LIGHT
CHAIN
(Oryctolagus
cuniculus) 		4 / 4 VAL B 125
VAL B 130
TYR B 185
GLN B 184
 None
 1.32A 5qgqA-5dscB:
undetectable		 5qgqA-5dscB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5dsc FAB HOU24.B LIGHT
CHAIN
(Oryctolagus
cuniculus) 		4 / 4 VAL B 125
VAL B 130
TYR B 185
GLN B 184
 None
 1.34A 5qhbA-5dscB:
undetectable		 5qhbA-5dscB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5dsc FAB HOU24.B LIGHT
CHAIN
(Oryctolagus
cuniculus) 		4 / 5 TYR B  92
TYR B  28
GLY B  91
GLY B  90
 None
 1.18A 5x7pA-5dscB:
undetectable		 5x7pA-5dscB:
10.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 5dsc FAB HOU24.B LIGHT
CHAIN
(Oryctolagus
cuniculus) 		4 / 4 VAL B  15
GLY B 108
ASP B 109
ASP B 169
 None
 0.20A 6cjkC-5dscB:
27.1		 6cjkC-5dscB:
81.00