SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dse'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		3 / 3 GLN A 540
ILE A 839
HIS A 553
 None
 0.74A 1fm9A-5dseA:
undetectable		 1fm9A-5dseA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		4 / 4 LYS A 439
LEU A 436
ALA A 438
LEU A 420
 None
 1.42A 2roxA-5dseA:
undetectable		 2roxA-5dseA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		4 / 5 PHE A 242
ILE A 268
GLY A 240
HIS A 226
 None
 1.36A 3r0lD-5dseA:
undetectable		 3r0lD-5dseA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		5 / 12 LEU A 214
LEU A 187
THR A 254
ASN A 256
LEU A 257
 None
 0.90A 3r9cA-5dseA:
undetectable		 3r9cA-5dseA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		4 / 7 ASN A 582
TYR A 579
LEU A 585
PHE A 519
 None
 1.13A 4awuA-5dseA:
undetectable		 4awuA-5dseA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		5 / 12 PHE A 504
ALA A 507
ALA A 470
VAL A 458
LEU A 435
 None
 1.06A 4j6dA-5dseA:
undetectable		 4j6dA-5dseA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		5 / 12 PHE A 504
ALA A 507
ALA A 470
VAL A 458
LEU A 435
 None
 1.09A 4j6dB-5dseA:
undetectable		 4j6dB-5dseA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		5 / 11 PHE A 504
ALA A 507
ALA A 470
VAL A 458
LEU A 435
 None
 1.15A 4jbtB-5dseA:
undetectable		 4jbtB-5dseA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		3 / 3 GLU A 450
ALA A 451
PHE A 454
 None
 0.53A 4v1fA-5dseA:
undetectable		 4v1fA-5dseA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		3 / 3 GLU A 450
ALA A 451
PHE A 454
 None
 0.59A 4v1fC-5dseA:
undetectable		 4v1fC-5dseA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		5 / 10 MET A 273
LEU A 269
GLU A 267
GLY A 238
LEU A 235
 None
 1.40A 5dxbA-5dseA:
undetectable		 5dxbA-5dseA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		4 / 4 LEU A 787
LEU A 808
GLY A 805
GLU A 806
 None
 1.09A 5hhjA-5dseA:
undetectable		 5hhjA-5dseA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		4 / 4 LYS A 439
LEU A 436
ALA A 438
LEU A 420
 None
 1.33A 6gnrA-5dseA:
undetectable		 6gnrA-5dseA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens) 		4 / 4 LYS A 439
LEU A 436
ALA A 438
LEU A 420
 None
 1.33A 6gnrB-5dseA:
undetectable		 6gnrB-5dseA:
9.46