SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1O76_A_CAMA1420_0 (CYTOCHROME P450-CAM)	5dst	PROTEIN ARGININE N-METHYLTRANSFERASE 8 (Homo sapiens)	5 / 10	THR A 270 LEU A 346 VAL A 304 VAL A 223 VAL A 224	None	1.44A	1o76A-5dstA: undetectable	1o76A-5dstA: 20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRE_X_TOPX300_1 (DIHYDROFOLATE REDUCTASE)	5dst	PROTEIN ARGININE N-METHYLTRANSFERASE 8 (Homo sapiens)	5 / 9	ALA A 203 LEU A 116 LEU A 174 VAL A 172 SER A 126	None	1.27A	3freX-5dstA: undetectable	3freX-5dstA: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_C_SAMC401_1 (MNMC2)	5dst	PROTEIN ARGININE N-METHYLTRANSFERASE 8 (Homo sapiens)	4 / 6	GLY A 121 GLU A 141 ASP A 117 GLU A 170	SAH A 401 ( 3.8A) SAH A 401 (-2.7A) SAH A 401 ( 3.9A) SAH A 401 (-3.3A)	0.98A	3vywC-5dstA: 5.8	3vywC-5dstA: 23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JS5_A_ASCA202_0 (CYTOCHROME C')	5dst	PROTEIN ARGININE N-METHYLTRANSFERASE 8 (Homo sapiens)	3 / 3	CYH A 318 LYS A 320 HIS A 319	None	1.07A	5js5A-5dstA: undetectable	5js5A-5dstA: 18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A93_B_8NUB3001_1 (5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562)	5dst	PROTEIN ARGININE N-METHYLTRANSFERASE 8 (Homo sapiens)	4 / 5	ASP A 92 ILE A 124 PHE A 128 ASN A 312	None	1.18A	6a93B-5dstA: undetectable	6a93B-5dstA: 21.27

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1O76_A_CAMA1420_0","CYTOCHROME P450-CAM","5dst","PROTEIN ARGININE N-METHYLTRANSFERASE 8","Homo sapiens",5,"THR A 270;LEU A 346;VAL A 304;VAL A 223;VAL A 224","None","1.44A","1o76A-5dstA:undetectable","1o76A-5dstA:20.66"],["3FRE_X_TOPX300_1","DIHYDROFOLATE REDUCTASE","5dst","PROTEIN ARGININE N-METHYLTRANSFERASE 8","Homo sapiens",5,"ALA A 203;LEU A 116;LEU A 174;VAL A 172;SER A 126","None","1.27A","3freX-5dstA:undetectable","3freX-5dstA:21.13"],["3VYW_C_SAMC401_1","MNMC2","5dst","PROTEIN ARGININE N-METHYLTRANSFERASE 8","Homo sapiens",4,"GLY A 121;GLU A 141;ASP A 117;GLU A 170","SAH A 401 ( 3.8A);SAH A 401 (-2.7A);SAH A 401 ( 3.9A);SAH A 401 (-3.3A)","0.98A","3vywC-5dstA:5.8","3vywC-5dstA:23.23"],["5JS5_A_ASCA202_0","CYTOCHROME C'","5dst","PROTEIN ARGININE N-METHYLTRANSFERASE 8","Homo sapiens",3,"CYH A 318;LYS A 320;HIS A 319","None","1.07A","5js5A-5dstA:undetectable","5js5A-5dstA:18.04"],["6A93_B_8NUB3001_1","5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562","5dst","PROTEIN ARGININE N-METHYLTRANSFERASE 8","Homo sapiens",4,"ASP A  92;ILE A 124;PHE A 128;ASN A 312","None","1.18A","6a93B-5dstA:undetectable","6a93B-5dstA:21.27"]]