SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dt5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		4 / 6 LEU A 204
ILE A  77
TRP A  79
VAL A 154
 None
 0.90A 1db1A-5dt5A:
undetectable		 1db1A-5dt5A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		5 / 11 ILE A 346
ILE A 158
PHE A 289
PRO A 163
ILE A 291
 None
 1.03A 1dg5A-5dt5A:
undetectable		 1dg5A-5dt5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		5 / 11 LEU A 194
ILE A 251
GLY A 215
CYH A 286
LEU A 218
 None
 1.33A 2bxeA-5dt5A:
undetectable		 2bxeA-5dt5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		5 / 12 LEU A 194
ILE A 251
GLY A 215
CYH A 286
LEU A 218
 None
 1.27A 2bxeB-5dt5A:
undetectable		 2bxeB-5dt5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		4 / 6 HIS A 125
ASP A  39
THR A  38
HIS A 180
 None
 1.47A 2einA-5dt5A:
undetectable
2einC-5dt5A:
undetectable		 2einA-5dt5A:
20.33
2einC-5dt5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		4 / 5 ALA A 353
ASP A 400
ASP A 418
ASP A 366
 None
 1.18A 2nyuB-5dt5A:
undetectable		 2nyuB-5dt5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		5 / 11 THR A  11
ILE A  65
ILE A 415
ALA A 430
VAL A  70
 None
 1.13A 2qhfA-5dt5A:
undetectable		 2qhfA-5dt5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		5 / 11 ASN A 161
GLU A 162
TYR A 294
GLU A 350
TRP A 396
 None
 0.77A 2v3dB-5dt5A:
15.9		 2v3dB-5dt5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		5 / 12 ILE A 390
PHE A 330
ALA A 243
LEU A 248
ILE A 291
 None
 1.32A 2xkwB-5dt5A:
undetectable		 2xkwB-5dt5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		5 / 12 ILE A  82
ILE A  77
PHE A 208
VAL A 154
PHE A 147
 None
 1.16A 2ygpA-5dt5A:
undetectable		 2ygpA-5dt5A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		4 / 6 HIS A 125
ASP A  39
THR A  38
HIS A 180
 None
 1.48A 2zxwN-5dt5A:
undetectable
2zxwP-5dt5A:
undetectable		 2zxwN-5dt5A:
20.33
2zxwP-5dt5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		3 / 3 LYS A 427
ARG A 369
ASP A 409
 None
 1.42A 3o7wA-5dt5A:
undetectable		 3o7wA-5dt5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		3 / 3 TYR A  55
ASP A  53
ASP A  49
 None
 0.98A 3ou7B-5dt5A:
undetectable		 3ou7B-5dt5A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		3 / 3 TYR A 294
TYR A 372
GLU A 403
 None
 0.95A 3pfgA-5dt5A:
undetectable		 3pfgA-5dt5A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		5 / 12 GLY A 413
VAL A 380
TYR A 393
ASN A 351
HIS A 376
 None
 1.37A 4ffwA-5dt5A:
undetectable		 4ffwA-5dt5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		5 / 12 ILE A 346
ILE A 158
PHE A 289
PRO A 163
ILE A 291
 None
 1.02A 4m2xA-5dt5A:
undetectable		 4m2xA-5dt5A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		4 / 8 TRP A 118
SER A 170
ILE A  31
TRP A  32
 None
 1.23A 4ms4A-5dt5A:
undetectable		 4ms4A-5dt5A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		6 / 11 ALA A 339
LEU A 337
TYR A 341
LEU A 333
ARG A 245
LEU A 248
 None
 1.37A 4wg0E-5dt5A:
undetectable
4wg0F-5dt5A:
undetectable
4wg0G-5dt5A:
undetectable		 4wg0E-5dt5A:
2.88
4wg0F-5dt5A:
2.88
4wg0G-5dt5A:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		4 / 8 PHE A 168
ALA A 243
HIS A 309
LEU A 173
 None
 1.14A 5dzkF-5dt5A:
2.1
5dzkT-5dt5A:
undetectable		 5dzkF-5dt5A:
21.02
5dzkT-5dt5A:
0.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		4 / 7 TRP A  32
ASP A  39
THR A  38
HIS A 180
 None
 1.37A 5iy5A-5dt5A:
undetectable
5iy5C-5dt5A:
undetectable		 5iy5A-5dt5A:
20.33
5iy5C-5dt5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		4 / 8 THR A  11
THR A  13
ARG A 424
ILE A 415
 None
 1.05A 5jhdE-5dt5A:
undetectable
5jhdG-5dt5A:
undetectable		 5jhdE-5dt5A:
18.74
5jhdG-5dt5A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		4 / 5 GLN A 367
ASP A 366
SER A 429
ARG A 369
 None
 1.50A 5w4zA-5dt5A:
8.6		 5w4zA-5dt5A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		4 / 6 LEU A 140
ALA A 143
SER A 196
THR A 284
 None
 0.74A 6f88A-5dt5A:
undetectable		 6f88A-5dt5A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5dt5 BETA-GLUCOSIDASE
(Exiguobacterium
antarcticum) 		4 / 7 ASP A 249
ARG A 245
TYR A 341
ASP A 240
 None
 1.28A 6mn5E-5dt5A:
undetectable		 6mn5E-5dt5A:
10.76