SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dt9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 ILE A 145
LEU A 307
VAL A 121
MET A 111
GLU A 314
 None
 0.76A 1dtlA-5dt9A:
undetectable		 1dtlA-5dt9A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 LEU A 110
LEU A 113
GLN A 117
MET A 147
LEU A 316
 None
 1.12A 1gs4A-5dt9A:
undetectable		 1gs4A-5dt9A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 TRP A 351
TYR A 265
LEU A 267
 None
 1.08A 1kxhA-5dt9A:
undetectable		 1kxhA-5dt9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 PHE A 234
LEU A 201
LEU A 251
LEU A 255
 None
 0.93A 2bfpA-5dt9A:
undetectable		 2bfpA-5dt9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 PHE A 234
LEU A 201
LEU A 251
LEU A 255
 None
 0.93A 2bfpD-5dt9A:
4.8		 2bfpD-5dt9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 9 VAL A  52
GLY A  33
LEU A  59
LEU A  41
ASP A  12
 SO4  A 404 ( 4.9A)
None
None
None
None
 1.36A 2j2pB-5dt9A:
undetectable
2j2pC-5dt9A:
undetectable		 2j2pB-5dt9A:
19.95
2j2pC-5dt9A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 LEU A 110
LEU A 113
GLN A 117
MET A 147
LEU A 316
 None
 1.17A 2oz7A-5dt9A:
undetectable		 2oz7A-5dt9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ILE A  49
ALA A  93
ILE A  89
LEU A  60
THR A  73
 None
None
None
None
SO4  A 404 (-4.3A)
 1.28A 2zzaA-5dt9A:
undetectable		 2zzaA-5dt9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 GLU A 314
SER A 120
VAL A 121
 None
 0.76A 3eeoA-5dt9A:
3.4		 3eeoA-5dt9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 LEU A  30
GLY A  33
LEU A  60
VAL A  55
ILE A  89
 None
 0.88A 3frqB-5dt9A:
0.1		 3frqB-5dt9A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 VAL A 177
GLY A 127
ALA A 214
LEU A 138
ILE A 128
 None
None
NAD  A 401 (-4.2A)
None
None
 0.96A 3ku1A-5dt9A:
undetectable		 3ku1A-5dt9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 VAL A 177
GLY A 127
ALA A 214
LEU A 138
ILE A 128
 None
None
NAD  A 401 (-4.2A)
None
None
 0.97A 3ku1H-5dt9A:
5.8		 3ku1H-5dt9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 LEU A 285
CYH A 282
GLY A  70
THR A  71
LEU A  25
 None
 1.38A 3okxA-5dt9A:
undetectable		 3okxA-5dt9A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 LEU A 285
CYH A 282
GLY A  70
THR A  71
LEU A  25
 None
 1.34A 3okxB-5dt9A:
undetectable		 3okxB-5dt9A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 5 ILE A 277
THR A 274
THR A 275
PHE A  22
 None
 0.94A 3snfA-5dt9A:
undetectable		 3snfA-5dt9A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 VAL A  28
ILE A  29
LEU A  59
LEU A  41
 None
 0.88A 4l1wA-5dt9A:
undetectable		 4l1wA-5dt9A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 ILE A  49
ALA A  93
ILE A  89
LEU A  60
THR A  73
 None
None
None
None
SO4  A 404 (-4.3A)
 1.31A 4qi9C-5dt9A:
undetectable		 4qi9C-5dt9A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ILE A  49
ALA A  93
ILE A  89
LEU A  60
THR A  73
 None
None
None
None
SO4  A 404 (-4.3A)
 1.19A 4qlgA-5dt9A:
undetectable		 4qlgA-5dt9A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ILE A  49
ALA A  93
ILE A  89
LEU A  60
THR A  73
 None
None
None
None
SO4  A 404 (-4.3A)
 1.18A 4rgcA-5dt9A:
undetectable		 4rgcA-5dt9A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 PHE A  68
LEU A  47
GLY A  26
LEU A  25
PHE A  22
 None
 1.22A 4wnwA-5dt9A:
undetectable		 4wnwA-5dt9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 5 LEU A 171
GLU A 169
LEU A 210
HIS A 181
 None
 1.20A 4xi3B-5dt9A:
undetectable		 4xi3B-5dt9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ILE A 262
GLY A 264
ALA A 263
ASP A 239
ARG A 215
 None
NAD  A 401 (-3.6A)
NAD  A 401 (-3.3A)
NAD  A 401 (-4.1A)
SO4  A 410 ( 3.5A)
 1.05A 4xt8A-5dt9A:
undetectable		 4xt8A-5dt9A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ILE A 262
GLY A 264
ALA A 263
ASP A 239
THR A 259
 None
NAD  A 401 (-3.6A)
NAD  A 401 (-3.3A)
NAD  A 401 (-4.1A)
None
 1.08A 4xt8A-5dt9A:
undetectable		 4xt8A-5dt9A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 GLU A 355
SER A 357
GLU A 268
GLU A 104
TYR A 137
 None
 1.47A 5iqbD-5dt9A:
undetectable		 5iqbD-5dt9A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 6 ARG A  34
GLY A  33
THR A  53
SER A  51
 None
None
None
SO4  A 404 (-2.3A)
 1.09A 5ny7A-5dt9A:
undetectable		 5ny7A-5dt9A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 10 ILE A 129
GLY A 130
GLY A 135
VAL A 149
LEU A 150
 None
NAD  A 401 (-3.6A)
None
None
None
 0.84A 5o96C-5dt9A:
2.4
5o96D-5dt9A:
2.3		 5o96C-5dt9A:
22.87
5o96D-5dt9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 GLY A 130
ASP A 153
PRO A 155
LYS A 156
THR A 182
 NAD  A 401 (-3.6A)
NAD  A 401 (-2.3A)
NAD  A 401 ( 4.5A)
NAD  A 401 (-4.7A)
NAD  A 401 (-4.5A)
 0.99A 5x6yC-5dt9A:
3.5		 5x6yC-5dt9A:
19.55