SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dtb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5dtb CG3822
(Drosophila
melanogaster) 		4 / 6 TYR A 192
VAL A 204
ILE A 201
LEU A 131
 None
 0.93A 1j96A-5dtbA:
undetectable		 1j96A-5dtbA:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 12 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.59A 1lbcA-5dtbA:
38.7
1lbcC-5dtbA:
38.8		 1lbcA-5dtbA:
54.14
1lbcC-5dtbA:
54.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_B_CYZB329_1
(GLUTAMINE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 9 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.74A 1lbcB-5dtbA:
38.7		 1lbcB-5dtbA:
54.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 12 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.72A 1lbcA-5dtbA:
38.6
1lbcC-5dtbA:
38.8		 1lbcA-5dtbA:
54.14
1lbcC-5dtbA:
54.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 12 LEU A 142
ASN A 178
GLY A 181
VAL A 185
ILE A 201
 GLU  A 301 ( 3.6A)
GLU  A 301 ( 3.8A)
None
None
None
 1.19A 3h52A-5dtbA:
undetectable		 3h52A-5dtbA:
24.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 11 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.56A 3h6tA-5dtbA:
38.4
3h6tC-5dtbA:
39.1		 3h6tA-5dtbA:
54.14
3h6tC-5dtbA:
54.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_B_CYZB265_1
(GLUTAMATE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 9 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.62A 3h6tB-5dtbA:
38.8		 3h6tB-5dtbA:
54.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 11 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.49A 3h6tA-5dtbA:
38.4
3h6tC-5dtbA:
39.1		 3h6tA-5dtbA:
54.14
3h6tC-5dtbA:
54.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 12 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.66A 3iltB-5dtbA:
35.8
3iltE-5dtbA:
35.7		 3iltB-5dtbA:
54.79
3iltE-5dtbA:
54.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 10 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.64A 3iltB-5dtbA:
35.8
3iltE-5dtbA:
35.7		 3iltB-5dtbA:
54.79
3iltE-5dtbA:
54.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 8 TYR A  39
PRO A 109
MET A 111
LEU A 250
LYS A 254
 None
 0.32A 3lsfH-5dtbA:
38.3		 3lsfH-5dtbA:
54.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		4 / 7 TYR A  39
MET A 111
LEU A 250
LYS A 254
 None
 0.52A 3lslA-5dtbA:
37.9
3lslD-5dtbA:
37.7		 3lslA-5dtbA:
54.79
3lslD-5dtbA:
54.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		4 / 7 TYR A  39
MET A 111
LEU A 250
LYS A 254
 None
 0.53A 3lslA-5dtbA:
38.0
3lslD-5dtbA:
37.8		 3lslA-5dtbA:
54.79
3lslD-5dtbA:
54.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		4 / 6 TYR A  39
MET A 111
LEU A 250
LYS A 254
 None
 0.47A 3lslG-5dtbA:
37.8		 3lslG-5dtbA:
54.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_1
(GLUTAMATE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 9 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.44A 3tkdA-5dtbA:
39.2		 3tkdA-5dtbA:
54.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_2
(GLUTAMATE RECEPTOR 2)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 9 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.44A 3tkdB-5dtbA:
38.8		 3tkdB-5dtbA:
54.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 12 LEU A  82
GLY A  66
GLY A  77
ILE A  15
VAL A  60
 None
 1.12A 4a6dA-5dtbA:
undetectable		 4a6dA-5dtbA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 12 ILE A  57
ILE A 241
LEU A 250
ILE A  47
ASN A  54
 None
 1.20A 4o1eA-5dtbA:
undetectable		 4o1eA-5dtbA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 10 LEU A 142
GLY A 144
ASN A  76
SER A  67
ALA A  92
 GLU  A 301 ( 3.6A)
GOL  A 302 (-3.8A)
None
GOL  A 302 (-4.1A)
None
 1.12A 4xj7C-5dtbA:
undetectable
4xj7D-5dtbA:
undetectable		 4xj7C-5dtbA:
22.30
4xj7D-5dtbA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 10 LEU A 142
GLY A 145
ASN A  76
SER A  67
ALA A  92
 GLU  A 301 ( 3.6A)
GOL  A 302 ( 3.4A)
None
GOL  A 302 (-4.1A)
None
 1.05A 4xj7C-5dtbA:
undetectable
4xj7D-5dtbA:
undetectable		 4xj7C-5dtbA:
22.30
4xj7D-5dtbA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dtb CG3822
(Drosophila
melanogaster) 		4 / 5 GLU A 202
THR A 199
HIS A  45
LEU A 253
 None
 1.11A 5axaC-5dtbA:
undetectable		 5axaC-5dtbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 9 LEU A 242
ASN A 238
ILE A  91
ILE A  96
ILE A 241
 None
 0.95A 5kqxB-5dtbA:
undetectable		 5kqxB-5dtbA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 11 LEU A 242
ASN A 238
ILE A  91
ILE A  96
ILE A 241
 None
 0.96A 5kr2B-5dtbA:
undetectable		 5kr2B-5dtbA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 9 LEU A 242
ASN A 238
ILE A  91
ILE A  96
ILE A 241
 None
 0.98A 5kr2D-5dtbA:
undetectable		 5kr2D-5dtbA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 11 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.63A 6dlzA-5dtbA:
33.3
6dlzD-5dtbA:
32.8		 6dlzA-5dtbA:
14.77
6dlzD-5dtbA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5dtb CG3822
(Drosophila
melanogaster) 		5 / 11 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.62A 6dm1A-5dtbA:
33.3
6dm1D-5dtbA:
32.8		 6dm1A-5dtbA:
14.77
6dm1D-5dtbA:
14.77