SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dte'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		4 / 4 VAL A  79
ALA A 103
LEU A 121
PHE A 104
 None
 0.93A 1q97B-5dteA:
undetectable		 1q97B-5dteA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 10 GLY A  49
ALA A  50
ILE A  31
ILE A 280
THR A  93
 None
 1.01A 1t7iA-5dteA:
undetectable		 1t7iA-5dteA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 12 TYR A 313
ALA A 257
GLY A 264
VAL A 305
PRO A 255
 None
 1.14A 2okcA-5dteA:
undetectable		 2okcA-5dteA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 12 TYR A 313
ALA A 257
GLY A 264
VAL A 305
PRO A 255
 None
 1.10A 2okcB-5dteA:
undetectable		 2okcB-5dteA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 12 ALA A 225
THR A 269
PHE A  43
ASN A 140
GLY A 143
 None
None
ALL  A 401 ( 4.9A)
ALL  A 401 ( 4.9A)
None
 1.47A 3aodC-5dteA:
undetectable		 3aodC-5dteA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 12 GLY A  49
ALA A  50
ILE A  31
ILE A 280
THR A  93
 None
 0.83A 3el4A-5dteA:
undetectable		 3el4A-5dteA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 10 GLY A  49
ALA A  50
ILE A  31
ILE A 280
THR A  93
 None
 0.94A 3el9B-5dteA:
undetectable		 3el9B-5dteA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 9 ILE A 258
VAL A 261
TYR A 251
THR A 269
ILE A 270
 None
 1.35A 3p4wA-5dteA:
undetectable		 3p4wA-5dteA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 12 ILE A 294
LEU A  34
ILE A 289
ILE A  31
LEU A  61
 None
 1.10A 3w67B-5dteA:
undetectable		 3w67B-5dteA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		4 / 8 ASN A  81
GLN A  74
ASN A  95
THR A  72
 None
 1.40A 4d1yA-5dteA:
4.8
4d1yB-5dteA:
4.7		 4d1yA-5dteA:
27.39
4d1yB-5dteA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		4 / 7 ARG A 176
GLY A 143
ASN A 268
GLU A 147
 ALL  A 401 (-2.9A)
None
None
None
 0.94A 4g0vA-5dteA:
undetectable		 4g0vA-5dteA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		4 / 6 ARG A 176
GLY A 143
ASN A 268
GLU A 147
 ALL  A 401 (-2.9A)
None
None
None
 1.05A 4g0vB-5dteA:
undetectable		 4g0vB-5dteA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 9 ALA A  89
ASP A  88
GLY A 111
VAL A  79
ILE A  90
 None
 1.12A 4ll3B-5dteA:
undetectable		 4ll3B-5dteA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		4 / 6 ILE A 163
ILE A 219
PHE A 184
LEU A 151
 None
 0.98A 4m51A-5dteA:
undetectable		 4m51A-5dteA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 10 VAL A  63
THR A  93
VAL A  65
LEU A 117
LEU A  38
 None
 1.22A 4yb6A-5dteA:
1.8
4yb6E-5dteA:
undetectable		 4yb6A-5dteA:
23.31
4yb6E-5dteA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 10 VAL A  63
THR A  93
VAL A  65
LEU A 117
LEU A  38
 None
 1.19A 4yb6B-5dteA:
undetectable
4yb6C-5dteA:
undetectable		 4yb6B-5dteA:
23.31
4yb6C-5dteA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 10 LEU A 117
LEU A  38
VAL A  63
THR A  93
VAL A  65
 None
 1.20A 4yb6B-5dteA:
undetectable
4yb6F-5dteA:
2.0		 4yb6B-5dteA:
23.31
4yb6F-5dteA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		3 / 3 TRP A 200
GLU A  69
ASP A 118
 ALL  A 401 (-3.6A)
ALL  A 401 (-3.3A)
ALL  A 401 (-3.0A)
 1.01A 5gqbA-5dteA:
undetectable		 5gqbA-5dteA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 12 ALA A 107
THR A  72
GLN A  74
GLY A  77
GLU A  80
 None
 1.30A 5hfjF-5dteA:
3.7		 5hfjF-5dteA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 12 ALA A  50
LEU A  61
ILE A  62
ILE A  31
LEU A  34
 None
 1.28A 5uanB-5dteA:
undetectable		 5uanB-5dteA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5dte MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 12 VAL A 261
VAL A 234
GLY A 232
ALA A 205
ASN A 150
 None
 1.12A 6bqgA-5dteA:
undetectable		 6bqgA-5dteA:
16.43