SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dtp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 104
LEU A  78
ARG A 111
ILE A  93
VAL A  89
 None
 1.08A 2qd3A-5dtpA:
undetectable		 2qd3A-5dtpA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		4 / 7 THR A   5
VAL A  10
THR A  12
VAL A  48
 None
 0.46A 3em0B-5dtpA:
undetectable		 3em0B-5dtpA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		6 / 12 ASN A  94
ILE A  93
GLY A  59
ALA A  23
GLY A  51
LEU A  15
 None
 1.12A 3hs6B-5dtpA:
undetectable		 3hs6B-5dtpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		6 / 12 ASN A  94
ILE A  93
GLY A  59
ALA A  23
GLY A  51
LEU A  15
 None
 1.09A 4e1gA-5dtpA:
undetectable		 4e1gA-5dtpA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  93
GLY A  59
ALA A  23
GLY A  51
LEU A  15
 None
 1.09A 4e1gB-5dtpA:
undetectable		 4e1gB-5dtpA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  75
LEU A  78
LEU A  24
ALA A 105
LEU A 104
 None
 1.06A 4wg0B-5dtpA:
undetectable
4wg0C-5dtpA:
undetectable
4wg0D-5dtpA:
undetectable		 4wg0B-5dtpA:
4.90
4wg0C-5dtpA:
4.90
4wg0D-5dtpA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  75
LEU A  78
LEU A  24
ALA A 105
LEU A 104
 None
 1.06A 4wg0D-5dtpA:
undetectable
4wg0E-5dtpA:
undetectable
4wg0F-5dtpA:
undetectable		 4wg0D-5dtpA:
4.90
4wg0E-5dtpA:
4.90
4wg0F-5dtpA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  75
LEU A  78
LEU A  24
ALA A 105
LEU A 104
 None
 1.06A 4wg0F-5dtpA:
undetectable
4wg0G-5dtpA:
undetectable
4wg0H-5dtpA:
undetectable		 4wg0F-5dtpA:
4.90
4wg0G-5dtpA:
4.90
4wg0H-5dtpA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  75
LEU A  78
LEU A  24
ALA A 105
LEU A 104
 None
 1.08A 4wg0H-5dtpA:
undetectable
4wg0I-5dtpA:
undetectable
4wg0J-5dtpA:
undetectable		 4wg0H-5dtpA:
4.90
4wg0I-5dtpA:
4.90
4wg0J-5dtpA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 105
LEU A 104
LEU A  24
LEU A  75
LEU A  78
 None
 1.08A 4wg0G-5dtpA:
undetectable
4wg0H-5dtpA:
undetectable
4wg0I-5dtpA:
undetectable		 4wg0G-5dtpA:
4.90
4wg0H-5dtpA:
4.90
4wg0I-5dtpA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  75
LEU A  78
LEU A  24
ALA A 105
LEU A 104
 None
 1.05A 4wg0J-5dtpA:
undetectable
4wg0K-5dtpA:
undetectable
4wg0L-5dtpA:
undetectable		 4wg0J-5dtpA:
4.90
4wg0K-5dtpA:
4.90
4wg0L-5dtpA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 105
LEU A 104
LEU A  24
LEU A  75
LEU A  78
 None
 1.06A 4wg0I-5dtpA:
undetectable
4wg0J-5dtpA:
undetectable
4wg0K-5dtpA:
undetectable		 4wg0I-5dtpA:
4.90
4wg0J-5dtpA:
4.90
4wg0K-5dtpA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 105
LEU A 104
LEU A  24
LEU A  75
LEU A  78
 None
 1.06A 4wg0K-5dtpA:
undetectable
4wg0L-5dtpA:
undetectable
4wg0M-5dtpA:
undetectable		 4wg0K-5dtpA:
4.90
4wg0L-5dtpA:
4.90
4wg0M-5dtpA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 166
LEU A 157
ARG A 111
VAL A 113
 None
 0.90A 5x80A-5dtpA:
undetectable
5x80B-5dtpA:
undetectable		 5x80A-5dtpA:
29.30
5x80B-5dtpA:
29.30