SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dtr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1NW3_A_ACTA600_0 (HISTONE METHYLTRANSFERASE DOT1L)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 5	LEU A 158 VAL A 160 TYR A 183 ARG A 231 THR A 235	None	0.16A	1nw3A-5dtrA: 39.8	1nw3A-5dtrA: 92.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1NW3_A_SAMA500_0 (HISTONE METHYLTRANSFERASE DOT1L)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	10 / 12	ASP A 161 GLY A 163 VAL A 169 LYS A 187 ALA A 188 PHE A 223 LEU A 224 PHE A 239 ASN A 241 PHE A 245	None None None None None None None 5F7 A 401 (-3.9A) 5F7 A 401 (-3.6A) None	0.48A	1nw3A-5dtrA: 39.8	1nw3A-5dtrA: 92.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1NW3_A_SAMA500_0 (HISTONE METHYLTRANSFERASE DOT1L)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	7 / 12	ASP A 161 GLY A 163 VAL A 170 LYS A 187 ALA A 188 PHE A 223 LEU A 224	None	1.49A	1nw3A-5dtrA: 39.8	1nw3A-5dtrA: 92.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QZZ_A_SAMA635_0 (ACLACINOMYCIN-10-HYD ROXYLASE)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	GLY A 163 GLY A 165 GLU A 186 ASP A 222 PHE A 223	None	0.82A	1qzzA-5dtrA: 11.8	1qzzA-5dtrA: 24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QZZ_A_SAMA635_0 (ACLACINOMYCIN-10-HYD ROXYLASE)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	GLY A 163 GLY A 165 GLU A 186 PRO A 191 ASP A 222	None	0.68A	1qzzA-5dtrA: 11.8	1qzzA-5dtrA: 24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDS_A_SAMA5635_0 (PROTEIN RDMB)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	GLY A 163 GLY A 165 GLU A 186 ASP A 222 PHE A 223	None	0.82A	1xdsA-5dtrA: 10.1	1xdsA-5dtrA: 24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDS_A_SAMA5635_0 (PROTEIN RDMB)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	GLY A 163 GLY A 165 GLU A 186 PRO A 191 ASP A 222	None	0.80A	1xdsA-5dtrA: 10.1	1xdsA-5dtrA: 24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDS_B_SAMB9635_0 (PROTEIN RDMB)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	GLY A 163 GLY A 165 GLU A 186 ASP A 222 PHE A 223	None	0.78A	1xdsB-5dtrA: 10.7	1xdsB-5dtrA: 24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDS_B_SAMB9635_0 (PROTEIN RDMB)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	GLY A 163 GLY A 165 GLU A 186 PRO A 191 ASP A 222	None	0.75A	1xdsB-5dtrA: 10.7	1xdsB-5dtrA: 24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NXE_B_SAMB303_0 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	ASP A 161 LEU A 162 GLY A 163 GLY A 165 ASN A 241	None None None None 5F7 A 401 (-3.6A)	0.64A	2nxeB-5dtrA: 11.1	2nxeB-5dtrA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YY8_B_SAMB500_0 (UPF0106 PROTEIN PH0461)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 11	VAL A 185 GLY A 184 VAL A 170 ILE A 232 GLU A 219	None	1.15A	2yy8A-5dtrA: 3.0 2yy8B-5dtrA: 2.6	2yy8A-5dtrA: 19.64 2yy8B-5dtrA: 19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DH0_A_SAMA220_0 (SAM DEPENDENT METHYLTRANSFERASE)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	VAL A 166 GLY A 165 GLY A 163 ALA A 192 LEU A 125	None	0.66A	3dh0A-5dtrA: 11.9	3dh0A-5dtrA: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DXY_A_SAMA1_0 (TRNA (GUANINE-N(7)-)-METH YLTRANSFERASE)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 11	GLY A 163 GLY A 165 GLU A 186 ASP A 222 PHE A 131	None None None None 5F7 A 401 (-4.4A)	0.97A	3dxyA-5dtrA: 9.4	3dxyA-5dtrA: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_B_CHDB500_0 (ILEAL BILE ACID-BINDING PROTEIN)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	4 / 7	THR A 217 GLU A 219 VAL A 185 VAL A 160	None	0.66A	3em0B-5dtrA: undetectable	3em0B-5dtrA: 17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRQ_A_ERYA195_0 (REPRESSOR PROTEIN MPHR(A))	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	THR A 197 LEU A 24 TYR A 209 ILE A 37 THR A 40	None	1.14A	3frqA-5dtrA: undetectable	3frqA-5dtrA: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FUU_A_ADNA0_1 (DIMETHYLADENOSINE TRANSFERASE)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	6 / 12	VAL A 185 GLY A 163 GLY A 165 GLU A 186 LYS A 187 ASP A 222	None	1.35A	3fuuA-5dtrA: 10.4	3fuuA-5dtrA: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IJD_B_C2FB314_1 (UNCHARACTERIZED PROTEIN)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	3 / 3	THR A 217 LYS A 261 GLU A 219	None	0.90A	3ijdB-5dtrA: undetectable	3ijdB-5dtrA: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K8M_B_ACRB820_1 (ALPHA-AMYLASE, SUSG)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	4 / 7	TYR A 183 GLU A 227 LEU A 158 LYS A 180	None	1.42A	3k8mB-5dtrA: undetectable	3k8mB-5dtrA: 19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QOW_A_SAMA417_0 (HISTONE-LYSINE N-METHYLTRANSFERASE)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	8 / 12	GLY A 163 VAL A 169 LYS A 187 ALA A 188 ASP A 222 PHE A 223 ASN A 241 PHE A 245	None None None None None None 5F7 A 401 (-3.6A) None	0.55A	3qowA-5dtrA: 39.1	3qowA-5dtrA: 92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QOW_A_SAMA417_0 (HISTONE-LYSINE N-METHYLTRANSFERASE)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	6 / 12	GLY A 163 VAL A 170 LYS A 187 ALA A 188 ASP A 222 PHE A 223	None	1.28A	3qowA-5dtrA: 39.1	3qowA-5dtrA: 92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RV5_D_DXCD92_0 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	4 / 5	VAL A 240 GLU A 226 LYS A 254 PHE A 272	None	1.47A	3rv5C-5dtrA: undetectable 3rv5D-5dtrA: undetectable	3rv5C-5dtrA: 12.57 3rv5D-5dtrA: 12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_C_SAMC401_1 (MNMC2)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	4 / 6	GLY A 165 GLU A 186 ASP A 222 ASP A 161	None	0.99A	3vywC-5dtrA: 8.6	3vywC-5dtrA: 23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_D_W9TD506_1 (HEMOLYTIC LECTIN CEL-III)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	4 / 5	ASP A 142 GLU A 138 GLY A 137 GLN A 172	None	1.40A	3w9tD-5dtrA: undetectable	3w9tD-5dtrA: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_E_W9TE505_1 (HEMOLYTIC LECTIN CEL-III)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	4 / 5	ASP A 142 GLU A 138 GLY A 137 GLN A 172	None	1.44A	3w9tE-5dtrA: undetectable	3w9tE-5dtrA: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_G_W9TG505_1 (HEMOLYTIC LECTIN CEL-III)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	4 / 5	ASP A 142 GLU A 138 GLY A 137 GLN A 172	None	1.48A	3w9tG-5dtrA: undetectable	3w9tG-5dtrA: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4B_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	4 / 8	PHE A 159 THR A 177 VAL A 144 VAL A 267	None None 5F7 A 401 ( 4.6A) 5F7 A 401 (-4.5A)	0.93A	4l4bA-5dtrA: undetectable	4l4bA-5dtrA: 20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJ8_A_SUVA2001_1 (HUMAN OX1R FUSION PROTEIN TO P.ABYSII GLYCOGEN SYNTHASE)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	ALA A 273 VAL A 293 VAL A 249 MET A 260 PHE A 223	None	1.23A	4zj8A-5dtrA: 4.1	4zj8A-5dtrA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_A_1GNA615_1 (PHIAB6 TAILSPIKE)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	3 / 3	TYR A 209 TYR A 20 GLN A 113	None	0.97A	5jsdA-5dtrA: undetectable 5jsdB-5dtrA: undetectable	5jsdA-5dtrA: 18.58 5jsdB-5dtrA: 18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_B_1GNB606_1 (PHIAB6 TAILSPIKE)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	3 / 3	TYR A 209 TYR A 20 GLN A 113	None	0.98A	5jsdB-5dtrA: undetectable 5jsdC-5dtrA: undetectable	5jsdB-5dtrA: 18.58 5jsdC-5dtrA: 18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5MVS_A_ADNA401_1 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	7 / 7	GLY A 163 GLU A 186 LYS A 187 ALA A 188 ASP A 222 PHE A 223 ASN A 241	None None None None None None 5F7 A 401 (-3.6A)	0.43A	5mvsA-5dtrA: 47.7	5mvsA-5dtrA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5MVS_B_ADNB401_1 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	8 / 8	GLY A 163 GLU A 186 LYS A 187 ALA A 188 ASP A 222 PHE A 223 ASN A 241 PHE A 245	None None None None None None 5F7 A 401 (-3.6A) None	0.27A	5mvsB-5dtrA: 46.9	5mvsB-5dtrA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W7P_A_SAMA501_1 (OXAC)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	4 / 5	TYR A 136 HIS A 182 ASP A 142 ARG A 101	None	1.49A	5w7pA-5dtrA: 10.3	5w7pA-5dtrA: 22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YBB_A_SAMA601_0 (TYPE I RESTRICTION-MODIFICA TION SYSTEM METHYLTRANSFERASE SUBUNIT)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	GLY A 165 GLY A 167 LYS A 187 PRO A 191 LEU A 224	None	1.07A	5ybbA-5dtrA: 8.2	5ybbA-5dtrA: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YBB_A_SAMA601_0 (TYPE I RESTRICTION-MODIFICA TION SYSTEM METHYLTRANSFERASE SUBUNIT)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	GLY A 165 LYS A 187 PRO A 191 LEU A 224 ASN A 241	None None None None 5F7 A 401 (-3.6A)	0.97A	5ybbA-5dtrA: 8.2	5ybbA-5dtrA: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YBB_B_SAMB601_0 (TYPE I RESTRICTION-MODIFICA TION SYSTEM METHYLTRANSFERASE SUBUNIT)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	ASP A 161 LYS A 187 PRO A 191 LEU A 224 ASN A 241	None None None None 5F7 A 401 (-3.6A)	0.84A	5ybbB-5dtrA: 7.0	5ybbB-5dtrA: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YBB_B_SAMB601_0 (TYPE I RESTRICTION-MODIFICA TION SYSTEM METHYLTRANSFERASE SUBUNIT)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 12	ASP A 161 PRO A 191 LEU A 224 ASN A 241 PHE A 223	None None None 5F7 A 401 (-3.6A) None	1.41A	5ybbB-5dtrA: 7.0	5ybbB-5dtrA: 21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6NJ9_K_SAMK500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	8 / 12	ASP A 161 GLY A 163 GLY A 165 GLN A 168 LYS A 187 ALA A 188 ASP A 222 PHE A 223	None	0.65A	6nj9K-5dtrA: 35.0	6nj9K-5dtrA: 92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6NJ9_K_SAMK500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	9 / 12	ASP A 161 GLY A 163 GLY A 165 VAL A 169 LYS A 187 ALA A 188 ASP A 222 PHE A 223 PHE A 239	None None None None None None None None 5F7 A 401 (-3.9A)	0.57A	6nj9K-5dtrA: 35.0	6nj9K-5dtrA: 92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6NQA_K_SAMK500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	7 / 10	ASP A 161 GLY A 163 GLY A 165 VAL A 169 LYS A 187 ASN A 241 PHE A 245	None None None None None 5F7 A 401 (-3.6A) None	0.80A	6nqaK-5dtrA: 33.5	6nqaK-5dtrA: 92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6NQA_K_SAMK500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 10	GLY A 163 GLY A 165 GLN A 168 LYS A 187 PHE A 245	None	0.86A	6nqaK-5dtrA: 33.5	6nqaK-5dtrA: 92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6NQA_K_SAMK500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 10	GLY A 165 GLN A 168 GLU A 186 LYS A 187 PHE A 245	None	1.17A	6nqaK-5dtrA: 33.5	6nqaK-5dtrA: 92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6NQA_K_SAMK500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	5dtr	HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC (Homo sapiens)	5 / 10	GLY A 165 VAL A 169 GLU A 186 LYS A 187 PHE A 245	None	1.06A	6nqaK-5dtrA: 33.5	6nqaK-5dtrA: 92.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1NW3_A_ACTA600_0","HISTONE METHYLTRANSFERASE DOT1L","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"LEU A 158;VAL A 160;TYR A 183;ARG A 231;THR A 235","None","0.16A","1nw3A-5dtrA:39.8","1nw3A-5dtrA:92.22"],["1NW3_A_SAMA500_0","HISTONE METHYLTRANSFERASE DOT1L","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",10,"ASP A 161;GLY A 163;VAL A 169;LYS A 187;ALA A 188;PHE A 223;LEU A 224;PHE A 239;ASN A 241;PHE A 245","None;None;None;None;None;None;None;5F7 A 401 (-3.9A);5F7 A 401 (-3.6A);None","0.48A","1nw3A-5dtrA:39.8","1nw3A-5dtrA:92.22"],["1NW3_A_SAMA500_0","HISTONE METHYLTRANSFERASE DOT1L","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",7,"ASP A 161;GLY A 163;VAL A 170;LYS A 187;ALA A 188;PHE A 223;LEU A 224","None","1.49A","1nw3A-5dtrA:39.8","1nw3A-5dtrA:92.22"],["1QZZ_A_SAMA635_0","ACLACINOMYCIN-10-HYDROXYLASE","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"GLY A 163;GLY A 165;GLU A 186;ASP A 222;PHE A 223","None","0.82A","1qzzA-5dtrA:11.8","1qzzA-5dtrA:24.46"],["1QZZ_A_SAMA635_0","ACLACINOMYCIN-10-HYDROXYLASE","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"GLY A 163;GLY A 165;GLU A 186;PRO A 191;ASP A 222","None","0.68A","1qzzA-5dtrA:11.8","1qzzA-5dtrA:24.46"],["1XDS_A_SAMA5635_0","PROTEIN RDMB","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"GLY A 163;GLY A 165;GLU A 186;ASP A 222;PHE A 223","None","0.82A","1xdsA-5dtrA:10.1","1xdsA-5dtrA:24.46"],["1XDS_A_SAMA5635_0","PROTEIN RDMB","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"GLY A 163;GLY A 165;GLU A 186;PRO A 191;ASP A 222","None","0.80A","1xdsA-5dtrA:10.1","1xdsA-5dtrA:24.46"],["1XDS_B_SAMB9635_0","PROTEIN RDMB","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"GLY A 163;GLY A 165;GLU A 186;ASP A 222;PHE A 223","None","0.78A","1xdsB-5dtrA:10.7","1xdsB-5dtrA:24.46"],["1XDS_B_SAMB9635_0","PROTEIN RDMB","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"GLY A 163;GLY A 165;GLU A 186;PRO A 191;ASP A 222","None","0.75A","1xdsB-5dtrA:10.7","1xdsB-5dtrA:24.46"],["2NXE_B_SAMB303_0","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"ASP A 161;LEU A 162;GLY A 163;GLY A 165;ASN A 241","None;None;None;None;5F7 A 401 (-3.6A)","0.64A","2nxeB-5dtrA:11.1","2nxeB-5dtrA:21.32"],["2YY8_B_SAMB500_0","UPF0106 PROTEIN PH0461","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"VAL A 185;GLY A 184;VAL A 170;ILE A 232;GLU A 219","None","1.15A","2yy8A-5dtrA:3.0;2yy8B-5dtrA:2.6","2yy8A-5dtrA:19.64;2yy8B-5dtrA:19.64"],["3DH0_A_SAMA220_0","SAM DEPENDENT METHYLTRANSFERASE","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"VAL A 166;GLY A 165;GLY A 163;ALA A 192;LEU A 125","None","0.66A","3dh0A-5dtrA:11.9","3dh0A-5dtrA:21.47"],["3DXY_A_SAMA1_0","TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"GLY A 163;GLY A 165;GLU A 186;ASP A 222;PHE A 131","None;None;None;None;5F7 A 401 (-4.4A)","0.97A","3dxyA-5dtrA:9.4","3dxyA-5dtrA:19.83"],["3EM0_B_CHDB500_0","ILEAL BILE ACID-BINDING PROTEIN","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",4,"THR A 217;GLU A 219;VAL A 185;VAL A 160","None","0.66A","3em0B-5dtrA:undetectable","3em0B-5dtrA:17.65"],["3FRQ_A_ERYA195_0","REPRESSOR PROTEIN MPHR(A)","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"THR A 197;LEU A  24;TYR A 209;ILE A  37;THR A  40","None","1.14A","3frqA-5dtrA:undetectable","3frqA-5dtrA:19.71"],["3FUU_A_ADNA0_1","DIMETHYLADENOSINE TRANSFERASE","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",6,"VAL A 185;GLY A 163;GLY A 165;GLU A 186;LYS A 187;ASP A 222","None","1.35A","3fuuA-5dtrA:10.4","3fuuA-5dtrA:20.87"],["3IJD_B_C2FB314_1","UNCHARACTERIZED PROTEIN","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",3,"THR A 217;LYS A 261;GLU A 219","None","0.90A","3ijdB-5dtrA:undetectable","3ijdB-5dtrA:20.87"],["3K8M_B_ACRB820_1","ALPHA-AMYLASE, SUSG","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",4,"TYR A 183;GLU A 227;LEU A 158;LYS A 180","None","1.42A","3k8mB-5dtrA:undetectable","3k8mB-5dtrA:19.06"],["3QOW_A_SAMA417_0","HISTONE-LYSINE N-METHYLTRANSFERASE","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",8,"GLY A 163;VAL A 169;LYS A 187;ALA A 188;ASP A 222;PHE A 223;ASN A 241;PHE A 245","None;None;None;None;None;None;5F7 A 401 (-3.6A);None","0.55A","3qowA-5dtrA:39.1","3qowA-5dtrA:92.50"],["3QOW_A_SAMA417_0","HISTONE-LYSINE N-METHYLTRANSFERASE","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",6,"GLY A 163;VAL A 170;LYS A 187;ALA A 188;ASP A 222;PHE A 223","None","1.28A","3qowA-5dtrA:39.1","3qowA-5dtrA:92.50"],["3RV5_D_DXCD92_0","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",4,"VAL A 240;GLU A 226;LYS A 254;PHE A 272","None","1.47A","3rv5C-5dtrA:undetectable;3rv5D-5dtrA:undetectable","3rv5C-5dtrA:12.57;3rv5D-5dtrA:12.57"],["3VYW_C_SAMC401_1","MNMC2","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",4,"GLY A 165;GLU A 186;ASP A 222;ASP A 161","None","0.99A","3vywC-5dtrA:8.6","3vywC-5dtrA:23.96"],["3W9T_D_W9TD506_1","HEMOLYTIC LECTIN CEL-III","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",4,"ASP A 142;GLU A 138;GLY A 137;GLN A 172","None","1.40A","3w9tD-5dtrA:undetectable","3w9tD-5dtrA:21.68"],["3W9T_E_W9TE505_1","HEMOLYTIC LECTIN CEL-III","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",4,"ASP A 142;GLU A 138;GLY A 137;GLN A 172","None","1.44A","3w9tE-5dtrA:undetectable","3w9tE-5dtrA:21.68"],["3W9T_G_W9TG505_1","HEMOLYTIC LECTIN CEL-III","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",4,"ASP A 142;GLU A 138;GLY A 137;GLN A 172","None","1.48A","3w9tG-5dtrA:undetectable","3w9tG-5dtrA:21.68"],["4L4B_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",4,"PHE A 159;THR A 177;VAL A 144;VAL A 267","None;None;5F7 A 401 ( 4.6A);5F7 A 401 (-4.5A)","0.93A","4l4bA-5dtrA:undetectable","4l4bA-5dtrA:20.84"],["4ZJ8_A_SUVA2001_1","HUMAN OX1R FUSION PROTEIN TO P.ABYSII GLYCOGEN SYNTHASE","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"ALA A 273;VAL A 293;VAL A 249;MET A 260;PHE A 223","None","1.23A","4zj8A-5dtrA:4.1","4zj8A-5dtrA:20.92"],["5JSD_A_1GNA615_1","PHIAB6 TAILSPIKE;PHIAB6 TAILSPIKE","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",3,"TYR A 209;TYR A  20;GLN A 113","None","0.97A","5jsdA-5dtrA:undetectable;5jsdB-5dtrA:undetectable","5jsdA-5dtrA:18.58;5jsdB-5dtrA:18.58"],["5JSD_B_1GNB606_1","PHIAB6 TAILSPIKE;PHIAB6 TAILSPIKE","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",3,"TYR A 209;TYR A  20;GLN A 113","None","0.98A","5jsdB-5dtrA:undetectable;5jsdC-5dtrA:undetectable","5jsdB-5dtrA:18.58;5jsdC-5dtrA:18.58"],["5MVS_A_ADNA401_1","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",7,"GLY A 163;GLU A 186;LYS A 187;ALA A 188;ASP A 222;PHE A 223;ASN A 241","None;None;None;None;None;None;5F7 A 401 (-3.6A)","0.43A","5mvsA-5dtrA:47.7","5mvsA-5dtrA:100.00"],["5MVS_B_ADNB401_1","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",8,"GLY A 163;GLU A 186;LYS A 187;ALA A 188;ASP A 222;PHE A 223;ASN A 241;PHE A 245","None;None;None;None;None;None;5F7 A 401 (-3.6A);None","0.27A","5mvsB-5dtrA:46.9","5mvsB-5dtrA:100.00"],["5W7P_A_SAMA501_1","OXAC","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",4,"TYR A 136;HIS A 182;ASP A 142;ARG A 101","None","1.49A","5w7pA-5dtrA:10.3","5w7pA-5dtrA:22.25"],["5YBB_A_SAMA601_0","TYPE I RESTRICTION-MODIFICATION SYSTEM METHYLTRANSFERASE SUBUNIT","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"GLY A 165;GLY A 167;LYS A 187;PRO A 191;LEU A 224","None","1.07A","5ybbA-5dtrA:8.2","5ybbA-5dtrA:21.27"],["5YBB_A_SAMA601_0","TYPE I RESTRICTION-MODIFICATION SYSTEM METHYLTRANSFERASE SUBUNIT","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"GLY A 165;LYS A 187;PRO A 191;LEU A 224;ASN A 241","None;None;None;None;5F7 A 401 (-3.6A)","0.97A","5ybbA-5dtrA:8.2","5ybbA-5dtrA:21.27"],["5YBB_B_SAMB601_0","TYPE I RESTRICTION-MODIFICATION SYSTEM METHYLTRANSFERASE SUBUNIT","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"ASP A 161;LYS A 187;PRO A 191;LEU A 224;ASN A 241","None;None;None;None;5F7 A 401 (-3.6A)","0.84A","5ybbB-5dtrA:7.0","5ybbB-5dtrA:21.27"],["5YBB_B_SAMB601_0","TYPE I RESTRICTION-MODIFICATION SYSTEM METHYLTRANSFERASE SUBUNIT","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"ASP A 161;PRO A 191;LEU A 224;ASN A 241;PHE A 223","None;None;None;5F7 A 401 (-3.6A);None","1.41A","5ybbB-5dtrA:7.0","5ybbB-5dtrA:21.27"],["6NJ9_K_SAMK500_0","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",8,"ASP A 161;GLY A 163;GLY A 165;GLN A 168;LYS A 187;ALA A 188;ASP A 222;PHE A 223","None","0.65A","6nj9K-5dtrA:35.0","6nj9K-5dtrA:92.50"],["6NJ9_K_SAMK500_0","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",9,"ASP A 161;GLY A 163;GLY A 165;VAL A 169;LYS A 187;ALA A 188;ASP A 222;PHE A 223;PHE A 239","None;None;None;None;None;None;None;None;5F7 A 401 (-3.9A)","0.57A","6nj9K-5dtrA:35.0","6nj9K-5dtrA:92.50"],["6NQA_K_SAMK500_0","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",7,"ASP A 161;GLY A 163;GLY A 165;VAL A 169;LYS A 187;ASN A 241;PHE A 245","None;None;None;None;None;5F7 A 401 (-3.6A);None","0.80A","6nqaK-5dtrA:33.5","6nqaK-5dtrA:92.50"],["6NQA_K_SAMK500_0","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"GLY A 163;GLY A 165;GLN A 168;LYS A 187;PHE A 245","None","0.86A","6nqaK-5dtrA:33.5","6nqaK-5dtrA:92.50"],["6NQA_K_SAMK500_0","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"GLY A 165;GLN A 168;GLU A 186;LYS A 187;PHE A 245","None","1.17A","6nqaK-5dtrA:33.5","6nqaK-5dtrA:92.50"],["6NQA_K_SAMK500_0","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","5dtr","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","Homo sapiens",5,"GLY A 165;VAL A 169;GLU A 186;LYS A 187;PHE A 245","None","1.06A","6nqaK-5dtrA:33.5","6nqaK-5dtrA:92.50"]]