SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dtu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5dtu PRP28
(Chaetomium
thermophilum) 		5 / 12 TYR A 488
ALA A 329
ILE A 307
ILE A 302
ILE A 271
 None
 1.14A 1xozA-5dtuA:
undetectable		 1xozA-5dtuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5dtu PRP28
(Chaetomium
thermophilum) 		4 / 8 TYR A 337
ARG A 314
LEU A 316
MET A 486
 None
 1.25A 3wipG-5dtuA:
undetectable
3wipH-5dtuA:
undetectable		 3wipG-5dtuA:
19.50
3wipH-5dtuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 5dtu PRP28
(Chaetomium
thermophilum) 		3 / 3 ARG A 535
GLU A 656
ASN A 625
 None
 0.85A 4imaD-5dtuA:
undetectable		 4imaD-5dtuA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 5dtu PRP28
(Chaetomium
thermophilum) 		3 / 3 ARG A 535
GLU A 656
ASN A 625
 None
 0.87A 4ip7D-5dtuA:
undetectable		 4ip7D-5dtuA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5dtu PRP28
(Chaetomium
thermophilum) 		3 / 3 PRO A 627
MET A 626
TYR A 633
 None
 1.11A 4qa0B-5dtuA:
4.2		 4qa0B-5dtuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5dtu PRP28
(Chaetomium
thermophilum) 		3 / 3 PRO A 627
MET A 626
TYR A 633
 None
 1.07A 4qa0A-5dtuA:
5.4		 4qa0A-5dtuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5dtu PRP28
(Chaetomium
thermophilum) 		3 / 3 GLU A 371
ALA A 372
PHE A 375
 ADP  A 801 ( 3.7A)
None
None
 0.44A 4v1fA-5dtuA:
undetectable		 4v1fA-5dtuA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5dtu PRP28
(Chaetomium
thermophilum) 		3 / 3 GLU A 371
ALA A 372
PHE A 375
 ADP  A 801 ( 3.7A)
None
None
 0.49A 4v1fC-5dtuA:
undetectable		 4v1fC-5dtuA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5dtu PRP28
(Chaetomium
thermophilum) 		4 / 7 ARG A 304
ILE A 307
GLN A 303
ILE A 264
 None
None
ADP  A 801 (-2.8A)
None
 0.98A 4w5oA-5dtuA:
undetectable		 4w5oA-5dtuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5dtu PRP28
(Chaetomium
thermophilum) 		4 / 6 ARG A 304
ILE A 307
GLN A 303
ILE A 264
 None
None
ADP  A 801 (-2.8A)
None
 0.95A 4w5qA-5dtuA:
undetectable		 4w5qA-5dtuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5dtu PRP28
(Chaetomium
thermophilum) 		4 / 6 ARG A 304
ILE A 307
GLN A 303
ILE A 264
 None
None
ADP  A 801 (-2.8A)
None
 1.01A 4w5tA-5dtuA:
undetectable		 4w5tA-5dtuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5dtu PRP28
(Chaetomium
thermophilum) 		4 / 6 ARG A 304
ILE A 307
GLN A 303
ILE A 264
 None
None
ADP  A 801 (-2.8A)
None
 0.95A 4z4cA-5dtuA:
undetectable		 4z4cA-5dtuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5dtu PRP28
(Chaetomium
thermophilum) 		4 / 6 ARG A 304
ILE A 307
GLN A 303
ILE A 264
 None
None
ADP  A 801 (-2.8A)
None
 0.96A 4z4dA-5dtuA:
undetectable		 4z4dA-5dtuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5dtu PRP28
(Chaetomium
thermophilum) 		4 / 7 ARG A 304
ILE A 307
GLN A 303
ILE A 264
 None
None
ADP  A 801 (-2.8A)
None
 0.95A 4z4eA-5dtuA:
undetectable		 4z4eA-5dtuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5dtu PRP28
(Chaetomium
thermophilum) 		4 / 7 ARG A 304
ILE A 307
GLN A 303
ILE A 264
 None
None
ADP  A 801 (-2.8A)
None
 0.97A 4z4gA-5dtuA:
undetectable		 4z4gA-5dtuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5dtu PRP28
(Chaetomium
thermophilum) 		5 / 12 ALA A 396
ASP A 415
GLY A 388
THR A 409
SER A 391
 None
 1.40A 5hfjG-5dtuA:
2.9		 5hfjG-5dtuA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5dtu PRP28
(Chaetomium
thermophilum) 		4 / 6 ARG A 304
ILE A 307
GLN A 303
ILE A 264
 None
None
ADP  A 801 (-2.8A)
None
 0.97A 6cbdA-5dtuA:
undetectable		 6cbdA-5dtuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 5dtu PRP28
(Chaetomium
thermophilum) 		5 / 12 PRO A 551
ILE A 552
ILE A 602
PHE A 555
PRO A 627
 None
 1.17A 6hlpA-5dtuA:
undetectable		 6hlpA-5dtuA:
21.65