SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5du3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		5 / 9 PHE A 396
LEU A 160
VAL A 159
GLY A 162
ASP A 398
 None
 1.43A 1dz8A-5du3A:
undetectable		 1dz8A-5du3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		5 / 9 PHE A 396
LEU A 160
VAL A 159
GLY A 162
ASP A 398
 None
 1.36A 2a1oB-5du3A:
undetectable		 2a1oB-5du3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		5 / 10 PHE A 396
LEU A 160
VAL A 159
GLY A 162
ASP A 398
 None
 1.40A 2cp4A-5du3A:
undetectable		 2cp4A-5du3A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 6 LEU A 456
LEU A 352
PRO A 467
VAL A 125
 None
 1.15A 2dqyC-5du3A:
undetectable		 2dqyC-5du3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 6 LEU A 394
PHE A 396
LEU A 131
PHE A 135
 None
 1.12A 2einP-5du3A:
undetectable
2einW-5du3A:
undetectable		 2einP-5du3A:
21.65
2einW-5du3A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 5 GLN A 201
THR A 157
HIS A 185
LEU A 221
 None
 1.29A 2zj0A-5du3A:
undetectable		 2zj0A-5du3A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 5 GLN A 201
THR A 157
HIS A 185
LEU A 221
 None
 1.27A 3ce6A-5du3A:
undetectable		 3ce6A-5du3A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 5 GLN A 201
THR A 157
HIS A 185
LEU A 221
 None
 1.31A 3ce6C-5du3A:
undetectable		 3ce6C-5du3A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 7 VAL A 125
TRP A 460
LYS A 465
GLU A 117
 None
 1.29A 3hs4A-5du3A:
undetectable		 3hs4A-5du3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		3 / 3 ARG A 227
THR A 409
THR A 263
 None
 0.79A 3k2hB-5du3A:
undetectable		 3k2hB-5du3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 8 SER A 198
ASN A 269
GLN A 201
TRP A 243
 None
 1.23A 3n62A-5du3A:
undetectable		 3n62A-5du3A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 8 SER A 198
ASN A 269
GLN A 201
TRP A 243
 None
 1.27A 3n66B-5du3A:
undetectable		 3n66B-5du3A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 5 VAL A 424
PHE A 457
ILE A 379
PHE A 455
 None
 1.11A 3owxB-5du3A:
undetectable		 3owxB-5du3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 7 SER A 198
ASN A 269
GLN A 201
TRP A 243
 None
 1.31A 4kcnB-5du3A:
undetectable		 4kcnB-5du3A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		3 / 3 ASP A 461
HIS A 464
LYS A 465
 None
 1.01A 4qzuD-5du3A:
undetectable		 4qzuD-5du3A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 7 TYR A 132
VAL A 458
ILE A 360
HIS A 133
 None
 1.14A 4xo7B-5du3A:
undetectable		 4xo7B-5du3A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 5 LEU A 394
PHE A 396
LEU A 131
PHE A 135
 None
 1.17A 5iy5P-5du3A:
undetectable
5iy5W-5du3A:
undetectable		 5iy5P-5du3A:
22.37
5iy5W-5du3A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 7 LEU A 331
TRP A 460
VAL A 125
SER A 128
 None
 1.15A 5umwA-5du3A:
undetectable
5umwF-5du3A:
undetectable		 5umwA-5du3A:
10.18
5umwF-5du3A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 8 SER A 198
ASN A 269
GLN A 201
TRP A 243
 None
 1.26A 5vunA-5du3A:
undetectable		 5vunA-5du3A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 8 SER A 198
ASN A 269
GLN A 201
TRP A 243
 None
 1.31A 5vunB-5du3A:
undetectable		 5vunB-5du3A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 8 SER A 198
ASN A 269
GLN A 201
TRP A 243
 None
 1.32A 5vuoB-5du3A:
undetectable		 5vuoB-5du3A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 5 LEU A 394
PHE A 396
LEU A 131
PHE A 135
 None
 1.08A 5x1fC-5du3A:
undetectable
5x1fJ-5du3A:
undetectable		 5x1fC-5du3A:
21.65
5x1fJ-5du3A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5du3 PLASMA PROTEASE C1
INHIBITOR
(Homo
sapiens) 		4 / 8 SER A 198
ASN A 269
GLN A 201
TRP A 243
 None
 1.34A 6auuB-5du3A:
undetectable		 6auuB-5du3A:
23.09