SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dud'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5dud YBGJ
YBGK
(Escherichia
coli) 		4 / 8 VAL B  44
ARG A 292
ALA B  13
GLU B  45
 None
 1.00A 1dmiA-5dudB:
undetectable
1dmiB-5dudB:
undetectable		 1dmiA-5dudB:
20.09
1dmiB-5dudB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 5dud YBGJ
YBGK
(Escherichia
coli) 		4 / 6 TYR B   7
GLU A 181
PRO A 256
VAL A 233
 None
 1.39A 1q13A-5dudB:
undetectable		 1q13A-5dudB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5dud YBGK
(Escherichia
coli) 		6 / 12 VAL A 244
ILE A 261
ILE A 174
ILE A 278
PHE A 280
LEU A 200
 None
 1.16A 1qhsA-5dudA:
undetectable		 1qhsA-5dudA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5dud YBGK
(Escherichia
coli) 		5 / 12 LEU A 150
MET A  94
VAL A  44
LEU A 113
ILE A   4
 None
 1.12A 1s9pA-5dudA:
undetectable		 1s9pA-5dudA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5dud YBGK
(Escherichia
coli) 		5 / 12 LEU A 150
MET A  94
VAL A  44
LEU A 113
ILE A   4
 None
 1.11A 1s9pD-5dudA:
undetectable		 1s9pD-5dudA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 5dud YBGJ
(Escherichia
coli) 		5 / 11 LEU B 191
GLY B 171
TYR B 125
ILE B  90
HIS B 120
 None
 1.40A 1tmxA-5dudB:
undetectable		 1tmxA-5dudB:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5dud YBGJ
(Escherichia
coli) 		5 / 10 ALA B 160
LEU B 191
GLN B 133
GLY B 131
PHE B 136
 None
 1.04A 1uhoA-5dudB:
undetectable		 1uhoA-5dudB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5dud YBGK
(Escherichia
coli) 		5 / 12 TYR A 209
ALA A 249
GLY A 208
SER A  27
PRO A 231
 None
 1.12A 2okcA-5dudA:
undetectable		 2okcA-5dudA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5dud YBGK
(Escherichia
coli) 		5 / 12 TYR A 209
ALA A 249
GLY A 208
SER A  27
PRO A 231
 None
 1.15A 2okcB-5dudA:
undetectable		 2okcB-5dudA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 5dud YBGJ
YBGK
(Escherichia
coli) 		4 / 8 GLY A 253
ILE B   9
CYH A 260
PHE A 193
 None
 0.75A 3ko0B-5dudA:
undetectable
3ko0J-5dudA:
undetectable		 3ko0B-5dudA:
16.39
3ko0J-5dudA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 5dud YBGJ
YBGK
(Escherichia
coli) 		4 / 8 GLY A 254
ILE B   9
CYH A 260
PHE A 193
 None
 1.02A 3ko0B-5dudA:
undetectable
3ko0J-5dudA:
undetectable		 3ko0B-5dudA:
16.39
3ko0J-5dudA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 5dud YBGJ
YBGK
(Escherichia
coli) 		4 / 8 GLY A 254
ILE B   9
CYH A 260
PHE A 193
 None
 0.99A 3ko0K-5dudA:
undetectable
3ko0S-5dudA:
undetectable		 3ko0K-5dudA:
16.39
3ko0S-5dudA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5dud YBGK
(Escherichia
coli) 		4 / 8 ASP A 131
SER A 129
MET A 125
GLY A 126
 None
 0.92A 4fo4A-5dudA:
undetectable		 4fo4A-5dudA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5dud YBGK
YBGJ
(Escherichia
coli;
Escherichia
coli) 		3 / 3 TYR B   7
HIS A 227
ARG A 257
 None
 0.94A 4htfA-5dudB:
undetectable		 4htfA-5dudB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 5dud YBGK
(Escherichia
coli) 		5 / 10 ASP A  15
GLY A 126
SER A 129
GLY A 137
ASP A 120
 None
 1.10A 4mmcA-5dudA:
undetectable		 4mmcA-5dudA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 5dud YBGK
(Escherichia
coli) 		5 / 10 ASP A  15
VAL A 121
GLY A 126
SER A 129
GLY A 137
 None
 1.29A 4mmcA-5dudA:
undetectable		 4mmcA-5dudA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 5dud YBGK
(Escherichia
coli) 		5 / 12 ASP A  15
VAL A 121
GLY A 126
SER A 129
GLY A 137
 None
 1.21A 4mmdB-5dudA:
undetectable		 4mmdB-5dudA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 5dud YBGK
(Escherichia
coli) 		5 / 9 ASP A  15
VAL A 121
GLY A 126
SER A 129
GLY A 137
 None
 1.19A 4mmeA-5dudA:
undetectable		 4mmeA-5dudA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 5dud YBGK
(Escherichia
coli) 		5 / 9 ASP A  15
VAL A 121
GLY A 126
SER A 129
GLY A 137
 None
 1.21A 4mmeB-5dudA:
undetectable		 4mmeB-5dudA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5dud YBGK
(Escherichia
coli) 		4 / 7 ALA A 288
ARG A 257
GLY A 179
GLU A 181
 None
 0.98A 5bs8A-5dudA:
undetectable
5bs8B-5dudA:
undetectable
5bs8C-5dudA:
undetectable		 5bs8A-5dudA:
20.44
5bs8B-5dudA:
20.71
5bs8C-5dudA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5dud YBGK
(Escherichia
coli) 		4 / 6 ALA A 288
ARG A 257
GLY A 179
GLU A 181
 None
 0.95A 5btgA-5dudA:
undetectable
5btgB-5dudA:
undetectable
5btgC-5dudA:
undetectable		 5btgA-5dudA:
20.44
5btgB-5dudA:
20.71
5btgC-5dudA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5dud YBGJ
(Escherichia
coli) 		4 / 4 GLU B 198
PRO B 199
ILE B 200
LEU B 201
 None
 1.14A 5m45A-5dudB:
undetectable		 5m45A-5dudB:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5dud YBGJ
(Escherichia
coli) 		4 / 4 GLU B 198
PRO B 199
ILE B 200
LEU B 201
 None
 1.12A 5m45G-5dudB:
undetectable		 5m45G-5dudB:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5dud YBGJ
(Escherichia
coli) 		4 / 4 GLU B 198
PRO B 199
ILE B 200
LEU B 201
 None
 1.06A 5m45J-5dudB:
undetectable		 5m45J-5dudB:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5dud YBGK
(Escherichia
coli) 		5 / 12 ALA A 270
ASN A 247
LEU A  32
GLY A 232
LEU A 211
 None
 1.07A 5x24A-5dudA:
undetectable		 5x24A-5dudA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 5dud YBGJ
YBGK
(Escherichia
coli) 		5 / 12 PHE B 192
ILE A  26
LEU B 130
GLY B 131
ASP B 193
 None
 1.04A 5x66A-5dudB:
undetectable
5x66B-5dudB:
undetectable		 5x66A-5dudB:
21.20
5x66B-5dudB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5dud YBGJ
YBGK
(Escherichia
coli) 		5 / 9 ILE A  26
LEU B 130
GLY B 135
PHE B 192
TYR B 138
 None
 1.33A 5x66C-5dudA:
undetectable		 5x66C-5dudA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5dud YBGK
(Escherichia
coli) 		6 / 10 ILE A  55
VAL A  86
ALA A  85
LEU A  72
LEU A  60
LEU A 100
 None
 1.20A 6f6nA-5dudA:
undetectable
6f6nB-5dudA:
undetectable		 6f6nA-5dudA:
13.87
6f6nB-5dudA:
12.90