SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5dux GALECTIN-4
(Homo
sapiens) 		3 / 3 VAL B  60
ALA B  61
HIS B 126
 None
 0.63A 1q23J-5duxB:
undetectable		 1q23J-5duxB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 5dux GALECTIN-4
(Homo
sapiens) 		4 / 5 PHE B  76
PHE B  46
PHE B 121
ILE B 147
 None
 1.07A 2v0mD-5duxB:
undetectable		 2v0mD-5duxB:
16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 5dux GALECTIN-4
(Homo
sapiens) 		6 / 6 HIS B  63
ASN B  65
ARG B  67
ASN B  77
TRP B  84
GLU B  87
 LAT  B 201 (-3.9A)
LAT  B 201 (-3.8A)
LAT  B 201 (-2.6A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
 0.25A 3galA-5duxB:
24.8		 3galA-5duxB:
36.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5dux GALECTIN-4
(Homo
sapiens) 		6 / 6 HIS B  63
ASN B  65
ARG B  67
ASN B  77
TRP B  84
GLU B  87
 LAT  B 201 (-3.9A)
LAT  B 201 (-3.8A)
LAT  B 201 (-2.6A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
 0.34A 3galB-5duxB:
24.5		 3galB-5duxB:
36.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5dux GALECTIN-4
(Homo
sapiens) 		3 / 3 ARG B  67
ASP B 141
ASP B  69
 LAT  B 201 (-2.6A)
None
None
 0.73A 3jayA-5duxB:
undetectable		 3jayA-5duxB:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5dux GALECTIN-4
(Homo
sapiens) 		3 / 3 ARG B  67
ASP B 141
ASP B  69
 LAT  B 201 (-2.6A)
None
None
 0.74A 3jb2A-5duxB:
undetectable		 3jb2A-5duxB:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5dux GALECTIN-4
(Homo
sapiens) 		3 / 3 ARG B  67
ASP B 141
ASP B  69
 LAT  B 201 (-2.6A)
None
None
 0.67A 3jb3A-5duxB:
undetectable		 3jb3A-5duxB:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5dux GALECTIN-4
(Homo
sapiens) 		4 / 6 TYR B 112
HIS B 111
VAL B 115
PHE B  50
 None
 1.11A 4a97E-5duxB:
undetectable		 4a97E-5duxB:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5dux GALECTIN-4
(Homo
sapiens) 		4 / 7 ASN B  77
TRP B  84
GLU B  87
ARG B  89
 LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
LAT  B 201 ( 3.7A)
 1.10A 6b8kA-5duxB:
24.6		 6b8kA-5duxB:
31.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5dux GALECTIN-4
(Homo
sapiens) 		6 / 7 HIS B  63
ASN B  65
ARG B  67
ASN B  77
TRP B  84
GLU B  87
 LAT  B 201 (-3.9A)
LAT  B 201 (-3.8A)
LAT  B 201 (-2.6A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
 0.21A 6b8kA-5duxB:
24.6		 6b8kA-5duxB:
31.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 5dux GALECTIN-4
(Homo
sapiens) 		6 / 8 HIS B  63
ASN B  65
ARG B  67
ASN B  77
TRP B  84
GLU B  87
 LAT  B 201 (-3.9A)
LAT  B 201 (-3.8A)
LAT  B 201 (-2.6A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
 0.31A 6b94A-5duxB:
19.5		 6b94A-5duxB:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 5dux GALECTIN-4
(Homo
sapiens) 		5 / 8 HIS B  63
ASN B  77
TRP B  84
GLU B  87
ARG B  89
 LAT  B 201 (-3.9A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
LAT  B 201 ( 3.7A)
 1.11A 6b94A-5duxB:
19.5		 6b94A-5duxB:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 5dux GALECTIN-4
(Homo
sapiens) 		6 / 10 HIS B  63
ASN B  65
ARG B  67
ASN B  77
TRP B  84
GLU B  87
 LAT  B 201 (-3.9A)
LAT  B 201 (-3.8A)
LAT  B 201 (-2.6A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
 0.33A 6b94A-5duxB:
19.4
6b94B-5duxB:
19.1		 6b94A-5duxB:
27.69
6b94B-5duxB:
27.69