SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dwd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
4 / 5 ILE A 139
ILE A  37
ILE A 203
LEU A  22
None
0.93A 1zgyA-5dwdA:
undetectable
1zgyA-5dwdA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
4 / 6 PRO A  48
LEU A 219
ARG A  44
GLY A  40
None
1.12A 2hs2B-5dwdA:
undetectable
2hs2B-5dwdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
4 / 8 LEU A 125
GLY A 143
GLY A 120
GLN A 119
None
0.77A 2wd9B-5dwdA:
3.3
2wd9B-5dwdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
4 / 5 LEU A 131
SER A 157
LEU A 135
PRO A 109
None
1.22A 3onnA-5dwdA:
4.6
3onnA-5dwdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
5 / 10 LEU A 114
ALA A 140
VAL A 161
VAL A 146
ILE A 138
None
0.96A 3oxwB-5dwdA:
undetectable
3oxwB-5dwdA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
5 / 10 LEU A 114
ALA A 140
VAL A 161
VAL A 146
ILE A 138
None
1.00A 3oxwD-5dwdA:
undetectable
3oxwD-5dwdA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
5 / 12 VAL A 172
HIS A 201
ASP A 169
GLY A  28
SER A 118
None
0.96A 3sufB-5dwdA:
undetectable
3sufB-5dwdA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
5 / 11 LEU A 162
ALA A 191
LEU A 181
GLY A 143
LEU A 125
None
1.22A 3uudA-5dwdA:
undetectable
3uudA-5dwdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
5 / 12 ILE A 139
ASP A 209
LEU A 208
GLY A 207
PHE A 141
None
1.39A 4foxE-5dwdA:
undetectable
4foxE-5dwdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
5 / 9 GLY A 200
SER A 199
ASP A 206
SER A 196
THR A 202
None
1.34A 4lb0A-5dwdA:
undetectable
4lb0A-5dwdA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
5 / 12 PHE A  71
TYR A  68
ASN A  56
GLY A  33
LEU A  36
None
1.49A 4oadA-5dwdA:
undetectable
4oadA-5dwdA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
5 / 10 LEU A 162
ALA A 191
LEU A 181
GLY A 143
LEU A 125
None
1.29A 5dxbA-5dwdA:
undetectable
5dxbA-5dwdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)
5dwd ESTERASE
(Pelagibacterium
halotolerans)
4 / 5 LEU A 215
PHE A 141
LEU A 162
TRP A  43
None
1.35A 5m10A-5dwdA:
1.6
5m10A-5dwdA:
18.42