SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5dwm PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Brucella
ovis) 		5 / 12 THR A 158
VAL A 120
LEU A 160
LEU A  81
LEU A 118
 None
 1.12A 1mx1C-5dwmA:
undetectable		 1mx1C-5dwmA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5dwm PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Brucella
ovis) 		4 / 6 ILE A 106
LEU A 165
LEU A 102
ASP A  84
 None
 1.08A 2rlfA-5dwmA:
undetectable
2rlfD-5dwmA:
undetectable		 2rlfA-5dwmA:
13.71
2rlfD-5dwmA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5dwm PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Brucella
ovis) 		4 / 7 PRO A 177
SER A 179
PRO A 173
GLY A 174
 None
 0.99A 2y7kA-5dwmA:
undetectable		 2y7kA-5dwmA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5dwm PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Brucella
ovis) 		5 / 12 PHE A  52
PRO A 177
SER A  85
ARG A  79
LEU A  81
 None
 1.32A 3iv6C-5dwmA:
undetectable		 3iv6C-5dwmA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 5dwm PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Brucella
ovis) 		6 / 12 SER A  29
ILE A  32
PRO A  34
GLY A  28
THR A  27
GLY A  26
 None
 1.12A 6b6cA-5dwmA:
undetectable		 6b6cA-5dwmA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 5dwm PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Brucella
ovis) 		6 / 12 SER A  29
ILE A  32
PRO A  34
GLY A  28
THR A  27
GLY A  26
 None
 1.10A 6b6fA-5dwmA:
undetectable		 6b6fA-5dwmA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5dwm PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Brucella
ovis) 		5 / 12 ILE A  88
ALA A  69
LEU A 133
ASP A  84
LEU A 105
 None
 1.23A 6ie8A-5dwmA:
undetectable		 6ie8A-5dwmA:
20.57